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CNIO participates in the ENCODE project: A stride forward in biomedical research
Date:9/6/2012

veloping and applying the annotation methodology for alternative splice forms. The results of this effort are discussed in one of the papers published in Nature and in related publications in the journals Genome Research and Molecular Biology and Evolution. These findings have helped substantially alter the way we understand the process of translating genetic information into the functional units formed by proteins.

For the CNIO group, forming part of Encode has meant the opportunity to test and refine new methods to unravel the complex problem of gene expression regulation, as well as a magnificent occasion to access information which, we can say, has proved indispensable (and sufficient) to round off analysis of the genomic data produced within the CNIO.

SOME KEY FACTS ON THE ENCODE PROJECT

Encode is a consortium funded by the NIH and headed by the National Human Genome Research Institute (NHGRI) in the United States and the EMBL European Bioinformatics Institute (EMBL-EBI) in the United Kingdom. Encode has mobilised the efforts of 442 scientists working out of 32 laboratories in the United Kingdom, United States, Singapore, Japan, Switzerland and Spain.

This ambitious international scientific partnership follows on from a pilot project which analysed a first 1% of the human genome and laid the technical foundations for what would come later. The results of the Encode pilot, summarised on a Nature front cover in 2007, were hugely impactful and have already collected many thousands of citations.

Full information on the Encode findings appear this week in thirty papers, six in Nature and a further 24 in journals such as Genome Research, and will simultaneously be made available through numerous servers and public information systems.

These results are already the touchstone for any existing or future genome study, including personalised cancer genomic initiatives
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Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

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