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CNIO participates in the ENCODE project: A stride forward in biomedical research
Date:9/6/2012

The international Encode project, a collaborative study bringing together hundred of scientists from all round the world, including researchers working at the Spanish National Cancer Research Centre (CNIO), published results yesterday mapping the control and regulation of genome activity. These results indicate a total of four million 'switches' controlling the gene activity of 147 types of human cells and tissue. This map provides us with the first comprehensive vision of the genome as a complex web of interactions, and goes far beyond our initial thinking, which assigned it a linear structure.

CNIO participates in Encode through the Gencode project. Gencode (www.gencodegenes.org), coordinated by Tim Hubbard of the Wellcome Trust Sanger Institute in the United Kingdom, is made up in turn of seven groups, with three European representatives including Roderic Guig's group at the CRG (Barcelona) and the CNIO group led by Alfonso Valencia. The CRG and CNIO groups involvement in the project is part funded by the Spanish Institute of Bioinformatics (www.inab.org) belonging to the Instituto de Salud Carlos III.

Gencode's mission is to create a reference geneset plotting the mass of information that comes out of Encode. We can say that Gencode supplies the system of references, annotations and coordinates needed to draw up the finished map. These references include the location, level of activity and type of genome-generated products, with regard to both protein-coding genes in their different forms of expression (transcripts) and alternatively expressed variants, and other regions coding for diverse types of RNA instead of proteins and pseudogenes.

The CNIO group, comprising Michael L. Tress, Jos Manuel Rodrguez, Iakes Ezkurdia as well as Alfonso Valencia, head of the CNIO's Structural Biology and Biocomputing Programme, is tasked with de
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Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

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