Navigation Links
CHOP introduces HLA typing by next-generation sequencing to its clinical services
Date:2/12/2014

Immunogenetics experts at The Children's Hospital of Philadelphia (CHOP) have developed a unique laboratory test to characterize the genes that encode HLA molecules. The test relies on faster, more comprehensive gene sequencing technology to type human leukocyte antigens (HLAs)--complex, highly variable proteins on cell surfaces that are essential to immune function.

The new test may improve transplantation outcomes through a more refined assessment of donor compatibility, and will expedite the donor selection process from bone marrow registries. It also provides an advanced tool for research in immunological diseases, infectious diseases, and pharmacogenomicsthe field that studies the influence of genetic variations on drug efficacy and toxicity.

"This new test addresses a sixty-year-old problem," said Dimitri Monos, Ph.D., director of the Immunogenetics Laboratory in the Division of Genomic Diagnostics at The Children's Hospital of Philadelphia. "Since the discovery of HLAs in the early 1950s, it has been a challenge to accurately and thoroughly characterize HLA gene sequences. We have now used next-generation sequencing tools to significantly advance HLA typing."

CHOP is the first hospital anywhere to offer this new comprehensive HLA-typing test, based on extensive research by Monos and colleagues. "This is a new, disruptive technology, with the potential to transform research and clinical practice, in transplantation and other fields," said Robert Doms, M.D., Ph.D., pathologist-in-chief at CHOP.

HLA genes are the most complex gene family known in the entire human genome. Gene sequences for HLAs are extremely polymorphic--highly variable, to a degree not adequately captured by conventional typing tests. Current tests often provide ambiguous and limited results, by sequencing only segments of HLA genes and failing to distinguish among different alleles suggested by a given sequence. In addition, preliminary testing often m
'/>"/>

Contact: John Ascenzi
ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. EyeLock Inc. Introduces EyeSwipe Nano TS Iris Scanning Turnstile Solution for Secure Access Control
2. BioFortis Inc., Introduces Next Generation Biobanking Software Platform for Biomarker-Based Clinical Research
3. TI introduces an all-in-one enterprise tablet solution for less than $70 total BOM
4. Integrated Biometrics Introduces Sherlock The Worlds Lightest, Thinnest, Smallest, Appendix F Mobile ID Fingerprint Sensors
5. Integrated Biometrics Introduces Sherlock
6. BluStor Introduces the Worlds First Platform to Protect the Full Stream of Mobile Security: Device, User, And Data
7. Stereotyping prime obstacle to women in commercial science
8. Eurofins MWG Operon and Floragenex close co-marketing agreement for RAD discovery and RAD genotyping
9. LABS, Inc. Launches Suite of Next-Generation Test Offerings; Focuses on Expanding Complex Biologic Testing Portfolio in 2012
10. Next-generation sequencing technology opens doors to discoveries
11. RIT leads development of next-generation infrared detectors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... , March 24, 2015   NexID Biometrics ... with critical security-authentication needs, today announced the beginning of ... (FFD) solution. The company, based in ... at the three-day Connect:ID Expo, which began here today ... NexID said version 2.0 of its SDK boosts the ...
(Date:3/23/2015)... BOSTON, Mass , March 23, 2015 SoundView ... shipment of NXT-ID,s (NASDAQ: NXTD ) Wocket smart wallet. SoundView ... world user feedback on their experience with the Wocket in ... experience at CVS, Whole Foods and other retailers, making both ... Kris Tuttle also says, "If the company meets ...
(Date:3/23/2015)... 2015  In the 2014 fiscal year, irs.gov recorded ... This figure accounts for a fraction of the estimated ... Report, exceeds $11 billion globally. The polygraph has traditionally ... has occurred. Investor Mark Saint Juste along ... Paolella partnered to administer the test in a ...
Breaking Biology News(10 mins):NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3
... Over time, the esoteric and sometimes downright strange quests ... others looking for perceived examples of waste in government ... Tom Brock,s National Science Foundation-supported treks to Yellowstone National ... might easily have been singled out as yet another ...
... VIRGINIA An article published in the September issue ... societies and offers insights for scientific societies to respond ... science. The American Institute of Biological Sciences (AIBS) ... of the biological sciences community and how this community ...
... , Sept. 12, 2013 BioClaim, Inc. announced as ... , Amerigroup Community Care of Florida ... biometric software at select physician offices in the ... with Amerigroup Florida," said Scott Kimmel , executive vice ...
Cached Biology News:Decades on, bacterium's discovery feted as paragon of basic science 2Decades on, bacterium's discovery feted as paragon of basic science 3Scientific societies face 'modern challenges' 2BioClaim, Inc. Signs Biometric Software Contract with Amerigroup Florida 2BioClaim, Inc. Signs Biometric Software Contract with Amerigroup Florida 3
(Date:5/4/2015)... /PRNewswire/ - Fluorinov Pharma (Fluorinov), a FACIT portfolio ... Dr. Roger J Garceau, to its Board of ... matters including corporate development and clinical strategy, his ... regulatory expertise as Fluorinov transitions to clinical development.  ... of pharmaceutical development experience to Fluorinov and most ...
(Date:5/4/2015)... Achieved primarily through a proprietary paraffin ... 10 to 100x better detail than the industry standard. ... existing light microscopy methods, it needed another medium to ... the frame of reference because it represents the highest ... from the earliest discovery days of Ultralight Histology was ...
(Date:5/4/2015)... 2015   Tocagen Inc. , a clinical-stage ... Tocagen,s ongoing investigational studies were presented at the 11 ... Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons ... in Washington, D.C. In ... with FDA and continues to advance towards initiation ...
(Date:5/1/2015)...  Northwest Biotherapeutics (NASDAQ: NWBO ) ("NW Bio"), ... for solid tumor cancers, announced today that the Company ... a $40 million investment from Woodford investment funds in ... million in NW Bio on November 19, 2014.  On ... the Company for a further $40 million investment in ...
Breaking Biology Technology:Roger J Garceau joins Fluorinov board, adds clinical expertise to bromodomain program and oncology pipeline 2Roger J Garceau joins Fluorinov board, adds clinical expertise to bromodomain program and oncology pipeline 3Tocagen Presents Updated Interim Survival Data from Ongoing Clinical Studies at American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Section on Tumors 2Tocagen Presents Updated Interim Survival Data from Ongoing Clinical Studies at American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Section on Tumors 3Tocagen Presents Updated Interim Survival Data from Ongoing Clinical Studies at American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Section on Tumors 4Tocagen Presents Updated Interim Survival Data from Ongoing Clinical Studies at American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Section on Tumors 5NW Bio Closes On $28.5 Million Second Tranche Of Woodford $40 Million Financing 2NW Bio Closes On $28.5 Million Second Tranche Of Woodford $40 Million Financing 3
... ... of Situational Leadership V™ series to its portfolio. , ... San Francisco, Calif. (PRWEB) October 2, 2009 ... (SLV) series specifically for biotech and specialty pharma companies. The new series includes Situational ...
... ... Orange County Emerging Growth Awards, recognizing companies headquartered in Orange County that have reached ... 12 months and that have made a positive impact on the local economy. ... Orange County, CA ...
... a plane the consequences can be fatal, not only for ... the aircraft fuselage, causing stresses in the material which can ... skin will detect such damage at an early stage and ... they don,t need any cables or batteries. They draw their ...
Cached Biology Technology:Perceptum Group Announces New Situational Leadership V Series 2Southern California Venture Network Announces Recipients of the 2009 Orange County Emerging Growth Awards 2Southern California Venture Network Announces Recipients of the 2009 Orange County Emerging Growth Awards 3Southern California Venture Network Announces Recipients of the 2009 Orange County Emerging Growth Awards 4Energy-autonomous sensors for aircraft 2
Desmosomal Protein Immunogen: Full length, native protein purified from human epidermal keratins. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Mouse monoclonal [SPM217] to Secretory Component Glycoprotein ( Abpromise for all tested applications)....
Mouse monoclonal [3G8] to MDMA ( Abpromise for all tested applications)....
Shh Antibody Shipping Temperature: HOT Storage Temperature: -20C...
Biology Products: