Navigation Links
CHEO scientist advances biotherapeutics as published in Cancer Cell
Date:10/18/2011

dl in layman terms.

"To deal with this 'sticky situation', the cell turns on a few pre-programmed rescue systems that either turbocharge the folding process or slow down the production of new proteins until the cell can catch up. If this doesn't work, the cell commits suicide to stop the damage from spreading," explained Dr. Douglas Mahoney lead author of the study and member of the Stojdl lab.

Dr. Stojdl's team has identified a way to short-circuit these rescue systems so that tumor cells go straight to suicide and healthy cells stay intact. The strategy works by applying a mild stress to the cells to force them to turn on these rescue systems. But when these cells encounter an oncolytic virus, instead of trying to fix the unfolded proteins, the cell is triggered to commit suicide.

This triggering effect also works with some common chemotherapeutics that are used in cancer clinics around the world today.


'/>"/>

Contact: Adrienne Vienneau
avienneau@cheo.on.ca
613-737-7600 x4144
Children's Hospital of Eastern Ontario Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists first to characterize barley plant-stem rust spore communication
2. Scientists discover dietary moisture window that boosts urinary tract health in cats
3. Southampton scientists herald significant breakthrough in study of chlamydia
4. Scientists move closer to predicting who will and will not fight off severe infections
5. Tagging tumors with gold: Scientists use gold nanorods to flag brain tumors
6. Uncharted territory: Scientists sequence the first carbohydrate biopolymer
7. New drug target for Alzheimers, stroke is discovered by University at Buffalo scientists
8. Scientists discover 3 new gene faults which could increase melanoma risk by 30 percent
9. Scientists identify microbes responsible for consuming natural gas in Deepwater Horizon spill
10. University of Texas marine scientists awarded $5.6 million for study of critical Arctic environment
11. WUSTL scientist wins prestigious Presidential Early Career Award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... 22, 2014  The 2014 Holiday Season may ... as Acuity Market Intelligence reports that the long ... open. Acuity forecasts that intensifying demand for smart ... biometrics will drive a global market of 2.5 ... by 2020.   According to ...
(Date:12/19/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has ... North America Perimeter Security Systems Market" report to ... The North American perimeter security market is ... 2014 to 2019. Although the U.S. market holds a ... is expected to grow at a higher CAGR ...
(Date:12/19/2014)... --  LaunchKey , the first decentralized mobile authentication and ... Things era, today announced the close of $3 million ... by Metamorphic Ventures with participation from ENIAC Ventures, Crosslink ... LaunchKey has raised $4 million to date, and will ... bring LaunchKey to market in 2015. LaunchKey ...
Breaking Biology News(10 mins):First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3
... PASADENA, Calif.Our belief as to whether we will likely succeed ... or losingdirectly affects the levels of neural effort put forth ... new brain-imaging study by neuroscientists at the California Institute of ... Richard A. Andersen, the James G. Boswell Professor of Neuroscience ...
... ASHEVILLE, NC USDA Forest Service Southern Research ... foresters, landowners and others concerned about nonnative invasive plants ... "A Field Guide for the Identification of Invasive Plants ... of the very popular "Nonnative Invasive Plants of Southern ...
... A unique blob-like creature that lived in the ocean approximately ... model in research published today in the journal Biology ... primitive species on early Earth looked like and how they ... on Earth today. The scientists, from Imperial ...
Cached Biology News:Caltech: Gain and loss in optimistic versus pessimistic brains 2Caltech: Gain and loss in optimistic versus pessimistic brains 3Forest Service updates free guide to 'Invasive Plants in Southern Forests' 2Ancient blob-like creature of the deep revealed by scientists 2
(Date:12/24/2014)... “Preparative & Process Chromatography Market by Instrument ... Buffers, Valves, Guages, Seals), Accessories, Services, End User ... 2019” provides a detailed overview of the major ... strategies impacting the preparative and process chromatography market ... revenue and share analysis. , Full Copy ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 Earlier this ... James L. Sherley, director of the Adult Stem Cell ... an often overlooked and under appreciated unique property of ... by Distributed Stem Cells: Misunderstood in the Past, Important ... to congress participants. He gave the address at ...
(Date:12/24/2014)... 2014 On Friday, December 19, ... the Omnibus and Continuing Resolution Appropriations Act of ... a condition eligible to receive funding through the ... the Department of Defense (DoD). The Hydrocephalus Association ... Capitol Hill, is celebrating this victory for the ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 ... mercaptan such as its definition, classification, application ... product specification, manufacturing process, and product cost ... and applications. The analysis also covers upstream ... channels, industry development trend and proposals. In ...
Breaking Biology Technology:Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2
... CITY, March 26 /PRNewswire-FirstCall/ - Aeterna Zentaris Inc.,(NASDAQ: ... company focused on,endocrine therapy and oncology, today reported ... the Company,s lead luteinizing,hormone-releasing hormone (LHRH) antagonist, in ... in benign prostatic hyperplasia (BPH), a,non-cancerous enlargement of ...
... (Amex:,ECI) ("Encision" or the "Company") announced today that ... for its AEM(R) articulating laparoscopic,instrument inserts., The ... shaft design to,accommodate the stresses generated by organ ... In addition, the new, easy to,operate rotation knob ...
... (LSE: SHP, NASDAQ: SHPGY, TSX: SHQ),the global specialty biopharmaceutical company, announces the release on,March 25, ... with the Shire Long Term Incentive Plan ("LTIP")., In accordance with the rules ... ... ...
Cached Biology Technology:Aeterna Zentaris Begins Second Phase 3 Trial of Cetrorelix for Benign Prostatic Hyperplasia 2Aeterna Zentaris Begins Second Phase 3 Trial of Cetrorelix for Benign Prostatic Hyperplasia 3Aeterna Zentaris Begins Second Phase 3 Trial of Cetrorelix for Benign Prostatic Hyperplasia 4Encision Launches Next Generation of EnTouch(R) Handles for Advanced Laparoscopic Procedures 2Shire plc: Long Term Incentive Plan 2
... KGaA. Physical form: Solution in 50% glycerol containing 20 ... , and 20 mM NaCl Preparation Unit Definition: One ... oligonucleotides equivalent to a ΔA 260 of 1.0 ... (reaction volume 2.625 ml). Assay: SDS-PAGE ≥ 90 ...
... Immunoassay Stabilizer is an aqueous solution that ... non-toxic chemicals in a PBS buffer (phosphate ... This product does not contain a preservative. ... and activity of dried protein components in ...
... StabilZyme NOBLE BSA-Free Stabilizer is a ... Stabilizer. It is an aqueous ... in a MOPS buffer (3-(N-Morpholino) propanesulfonic ... contains a combination of 0.02% methylisothiazolone ...
Mouse monoclonal antibody to PARK2 - Parkinson disease (autosomal recessive, juvenile) 2, parkin...
Biology Products: