Navigation Links
CHEO scientist advances biotherapeutics as published in Cancer Cell
Date:10/18/2011

Ottawa, Ontario October 18, 2011 Oncolytic virology uses live viruses to sense the genetic difference between a tumor and normal cell. Once the virus finds a tumor cell, it replicates inside that cell, kills it and then spreads to adjacent tumor cells to seed a therapeutic "chain reaction". As reported in today's issue of Cancer Cell, Dr. David Stojdl, a scientist from the Children's Hospital of Eastern Ontario Research Institute at the University of Ottawa has found a way to trick resistant cancer cells into committing suicide following oncolytic virus therapy.

When it comes to using oncolytic viruses to fight cancer, the outcome is a consequence of a battle between the genes that the virus has and the genes that the human host has. Using a technology called RNA Interference (RNAi) Dr. Stojdl's research team was able to systematically search through the entire human genome to find genes [that when inhibited] would make the viruses up to 10,000 times more potent at killing tumor cells without harming healthy cells. "Until now, scientists in our field have been focused on engineering the genes in the oncolytic virus itself to make them work better, and that has worked well to a point. This is the first study to look at all of the genes in the human genome to determine which ones we should manipulate to help the oncolytic therapy work better," said Dr. Stojdl.

Dr. Stojdl's research team has identified a series of genes that magnify the impact of oncolytic viruses. These genes normally control the endoplasmic reticulum stress response, or unfolded protein response. In essence, when the cell environment is toxic the cells have a tough time folding proteins. "A properly folded protein doesn't expose many sticky parts on its surface. Cells don't like mangled proteins because they get sticky. If you have sticky parts they combine with other proteins to make large, toxic 'balls' of protein - and this can kill the cell," explained Dr. Stojdl in layman terms.

"To deal with this 'sticky situation', the cell turns on a few pre-programmed rescue systems that either turbocharge the folding process or slow down the production of new proteins until the cell can catch up. If this doesn't work, the cell commits suicide to stop the damage from spreading," explained Dr. Douglas Mahoney lead author of the study and member of the Stojdl lab.

Dr. Stojdl's team has identified a way to short-circuit these rescue systems so that tumor cells go straight to suicide and healthy cells stay intact. The strategy works by applying a mild stress to the cells to force them to turn on these rescue systems. But when these cells encounter an oncolytic virus, instead of trying to fix the unfolded proteins, the cell is triggered to commit suicide.

This triggering effect also works with some common chemotherapeutics that are used in cancer clinics around the world today.


'/>"/>

Contact: Adrienne Vienneau
avienneau@cheo.on.ca
613-737-7600 x4144
Children's Hospital of Eastern Ontario Research Institute
Source:Eurekalert

Related biology news :

1. Scientists first to characterize barley plant-stem rust spore communication
2. Scientists discover dietary moisture window that boosts urinary tract health in cats
3. Southampton scientists herald significant breakthrough in study of chlamydia
4. Scientists move closer to predicting who will and will not fight off severe infections
5. Tagging tumors with gold: Scientists use gold nanorods to flag brain tumors
6. Uncharted territory: Scientists sequence the first carbohydrate biopolymer
7. New drug target for Alzheimers, stroke is discovered by University at Buffalo scientists
8. Scientists discover 3 new gene faults which could increase melanoma risk by 30 percent
9. Scientists identify microbes responsible for consuming natural gas in Deepwater Horizon spill
10. University of Texas marine scientists awarded $5.6 million for study of critical Arctic environment
11. WUSTL scientist wins prestigious Presidential Early Career Award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/16/2016)... 16, 2016 The global ... to reach USD 1.83 billion by 2024, according ... Inc. Technological proliferation and increasing demand in commercial ... to drive the market growth.      ... The development of advanced multimodal techniques for biometric ...
(Date:6/9/2016)... 9, 2016 Paris Police ... video security solution to ensure the safety of people and ... during the major tournament Teleste, an international technology ... services, announced today that its video security solution will be ... back up public safety across the country. The system roll-out ...
(Date:6/2/2016)... The Department of Transport Management (DOTM) of ... Dollar project, for the , Supply and Delivery ... IT Infrastructure , to Decatur ... Identity Management Solutions. Numerous renowned international vendors participated in the ... was selected for the most compliant and innovative solution. The ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... ... December 02, 2016 , ... ... of pharmaceutical and biotechnology companies dedicated to collaboratively developing improved chemistry, manufacturing ... supplying a vendor-supported, portable online UHPLC, with robust, probe-based sampling. , ...
(Date:12/2/2016)... leader in rapid infectious disease tests, introduced the Company,s newest product, the INSTI HIV ... http://photos.prnewswire.com/prnh/20161201/444905 ) Continue Reading ... ... , bioLytical was invited by the Clinton Health ... Self Test to 350 pharmacy representatives in Nairobi and Mombasa, ...
(Date:11/30/2016)... 30, 2016 /PRNewswire/ - Portage Biotech Inc. ("Portage" or ... is excited to announce the formation of EyGen, ... preclinical ophthalmology assets through proof of concept. EyGen,s ... by Portage Pharmaceuticals Limited and being developed for ... and anterior segment diseases. This agent has the ...
(Date:11/30/2016)... , Nov. 30, 2016  Tempus, a technology ... care, and Penn,s Abramson Cancer Center have partnered ... positive response to immunotherapy treatment based on next ... As part of a research collaboration, Tempus will ... melanoma cancer patient data to Penn. Utilizing next-generation ...
Breaking Biology Technology: