Navigation Links
CHEO scientist advances biotherapeutics as published in Cancer Cell
Date:10/18/2011

Ottawa, Ontario October 18, 2011 Oncolytic virology uses live viruses to sense the genetic difference between a tumor and normal cell. Once the virus finds a tumor cell, it replicates inside that cell, kills it and then spreads to adjacent tumor cells to seed a therapeutic "chain reaction". As reported in today's issue of Cancer Cell, Dr. David Stojdl, a scientist from the Children's Hospital of Eastern Ontario Research Institute at the University of Ottawa has found a way to trick resistant cancer cells into committing suicide following oncolytic virus therapy.

When it comes to using oncolytic viruses to fight cancer, the outcome is a consequence of a battle between the genes that the virus has and the genes that the human host has. Using a technology called RNA Interference (RNAi) Dr. Stojdl's research team was able to systematically search through the entire human genome to find genes [that when inhibited] would make the viruses up to 10,000 times more potent at killing tumor cells without harming healthy cells. "Until now, scientists in our field have been focused on engineering the genes in the oncolytic virus itself to make them work better, and that has worked well to a point. This is the first study to look at all of the genes in the human genome to determine which ones we should manipulate to help the oncolytic therapy work better," said Dr. Stojdl.

Dr. Stojdl's research team has identified a series of genes that magnify the impact of oncolytic viruses. These genes normally control the endoplasmic reticulum stress response, or unfolded protein response. In essence, when the cell environment is toxic the cells have a tough time folding proteins. "A properly folded protein doesn't expose many sticky parts on its surface. Cells don't like mangled proteins because they get sticky. If you have sticky parts they combine with other proteins to make large, toxic 'balls' of protein - and this can kill the cell," explained Dr. Stoj
'/>"/>

Contact: Adrienne Vienneau
avienneau@cheo.on.ca
613-737-7600 x4144
Children's Hospital of Eastern Ontario Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists first to characterize barley plant-stem rust spore communication
2. Scientists discover dietary moisture window that boosts urinary tract health in cats
3. Southampton scientists herald significant breakthrough in study of chlamydia
4. Scientists move closer to predicting who will and will not fight off severe infections
5. Tagging tumors with gold: Scientists use gold nanorods to flag brain tumors
6. Uncharted territory: Scientists sequence the first carbohydrate biopolymer
7. New drug target for Alzheimers, stroke is discovered by University at Buffalo scientists
8. Scientists discover 3 new gene faults which could increase melanoma risk by 30 percent
9. Scientists identify microbes responsible for consuming natural gas in Deepwater Horizon spill
10. University of Texas marine scientists awarded $5.6 million for study of critical Arctic environment
11. WUSTL scientist wins prestigious Presidential Early Career Award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... Neiker-Tecnalia is currently conducting research into the potato genes ... characterised by a reduction in rainfall and increased extremes ... the most resistant genes in order to create new ... conditions.The research is also seeking to find out how ... of greater drought and higher and lower temperatures. , ...
(Date:7/24/2014)... Expanding on his work with a new drug that successfully ... of Houston has received a $250,000 grant to expand his ... effort to treat a wider range of autoimmune diseases., Chandra ... biomedical Engineering at UH, previously published a study in Arthritis ... that successfully treated lupus in mice and reduced the number ...
(Date:7/24/2014)... gut that has gone undetected by scientists for decades. ... State University has found that more than half the ... named crAssphage, which infects one of the most common ... of bacteria is thought to be connected with obesity, ... in Nature Communications ., Robert A. Edwards, a ...
Breaking Biology News(10 mins):Neiker-Tecnalia is researching the potato genes that best adapt to climate change 2Biomedical engineer looks at new applications for novel lupus drug 2Biomedical engineer looks at new applications for novel lupus drug 3Newly discovered gut virus lives in half the world's population 2Newly discovered gut virus lives in half the world's population 3
... 2009 Two weeks after the rains begin, an elephant family ... up for pregnancy and birth. But when they wandered off their ... that elephants couldn,t eat it, according to a University of Utah ... research which suggests how climate change and human encroachment may ...
... hide from the immune system undermine the virus,s ability to ... 13 issue of the Journal of Experimental Medicine . ... When HIV infects a cell, a complex of human immune ... T cells by displaying bits of the virus on the ...
... two groups of researchers have come to the same conclusion: ... hearing loss. The new gene - called a microRNA - ... of hundreds of other molecules within sensory hair cells of ... genetic understanding of a condition that is common in humans ...
Cached Biology News:Diet secrets of 'the Royals' 2Diet secrets of 'the Royals' 3Diet secrets of 'the Royals' 4Diet secrets of 'the Royals' 5HIV pays a price for invisibility 2New insights into progressive hearing loss 2New insights into progressive hearing loss 3New insights into progressive hearing loss 4
(Date:7/24/2014)... SAN DIEGO , July 24, 2014 /PRNewswire/ ... company, announced today the appointment of Adam ... (COO). Cypher Genomics provides rapid and comprehensive annotation ... discovery and clinical reporting. "Cypher,s technology ... to improve healthcare by enhancing diagnostic accuracy, optimizing ...
(Date:7/23/2014)... 2014 Lyfebulb, the International Pemphigus Pemphigoid ... NASDAQ OMX First North Premier, Stockholm ... a collaboration to increase awareness of unmet needs ... event attended by more than sixty patients, physicians, ... health and wellness company dedicated to serving the ...
(Date:7/23/2014)... have made great strides in saving China,s endangered national ... over 65 giant panda reserves that have been established ... just 1596 pandas remain in the wild. , ... save the panda by improving genetic diversity, avoid inbreeding ... how are these high-profile programs doing so far? , ...
(Date:7/23/2014)... /PRNewswire-iReach/ -- Think Drinks are a neuroscience-backed drink regimen ... They are the first functional focus beverage to give ... alternative to the temporary fix associated with energy drinks. ... 29, 2014, with hopes to raise $50,000 over the ... http://photos.prnewswire.com/prnh/20140723/129697 Think Drinks were ...
Breaking Biology Technology:Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 2Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 3Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 2Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 3Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 4Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 5truBrain Neuroscientists To Launch More Effective, Healthier Alternative To Energy Drinks On Indiegogo 2
... Institute (VBI) at Virginia Tech have compiled a series ... to design, develop and manage next-generation databases of biological ... parts is essential if methods developed in other fields ... successful, this approach will result in significant productivity gains ...
... (SACRAMENTO, Calif.) UC Davis Cancer Center physicians today released ... Agent Orange have greatly increased risks of prostate cancer and ... the disease as compared to those who were not exposed. ... published in the September 15 issue of the journal ...
... May Minimize Viral Transmission, Including Norovirus , ... impact public health by minimizing the transmission of ... care providers. The researchers from the University ... University, Raleigh report their findings in the August ...
Cached Biology Technology:Tips on how to build a better home for biological parts 2Tips on how to build a better home for biological parts 3Exposure to Agent Orange linked to prostate cancer in Vietnam veterans 2Tips from the journals of the American Society for Microbiology 2Tips from the journals of the American Society for Microbiology 3Tips from the journals of the American Society for Microbiology 4
Human VASA Biotinylated Affinity Purified PAb...
Recombinant Mouse Matrilin-4, CF Protein Family: Extracellular Matrix Molecules, Chondrogenesis Markers...
An instrument that delivers an accurate and uniform amount of light energy to cells to photoactivate csiRNA products....
Use the DUALmembrane kit 3 to carry out DUALmembrane interaction analysis and cDNA library screening to characterize interactions between integral membrane proteins and to identify novel interaction ...
Biology Products: