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C. difficile spores spread superbug
Date:7/20/2009

"It will also facilitate determining the host factors important in disease and will lead to better diagnosis and treatment strategies to reduce the burden of C. difficile-associated diseases."

Because the team had established how to isolate and purify spores and trigger transmission of C. difficile in mice, they were also in a position test disinfectants commonly used in hospitals for their success at controlling infection. The alcohol-based disinfectants tested had no success in preventing transmission. Instead, a 20-minute surface disinfection using a sporicidal agent was necessary to reduce environmental spore contamination enough to eliminate transmission. Further results detailing the success of individual hospital disinfectants will be published in the coming months.

Today's publication provides a step towards reducing the burden on healthcare systems, which have seen a ten-fold increase in the incidence of C. difficile in the last decade. 56,000 cases were reported in the UK in 2007, although, the first a three months of 2009 saw a decline in incidence compared to the same period in 2008. The most severe complication is pseudomembranous colitis, an infection of the colon that can be lethal in patients with weakened immune systems.

"What this research essentially provides," says Dr Fiona Cooke, working in the Department of Medical Microbiology at Addenbrooke's Hospital, Cambridge, "is a better understanding of the interactions between C. difficile, the intestinal microbiota and the immune system of the host - in this case the mouse - primarily in response to antibiotic treatment but also in response to immune impaired hosts. This opens up numerous opportunities including the development of new probiotic approaches, which could restore the balance of the intestinal microbiota and promote health, are clear."

"This research has far reaching implications for treatment and infection control of a p
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Contact: Don Powell
don@sanger.ac.uk
44-122-349-6928
Wellcome Trust Sanger Institute
Source:Eurekalert

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