Navigation Links
C. difficile spores spread superbug
Date:7/20/2009

New research suggests that antibiotic treatment could be asymptomatically inducing the transmission of the healthcare-acquired infection, C. difficile, contributing to the outbreaks that have recently been widely reported in hospitals and other settings. A team of scientists have successfully mirrored the infection cycle of C. difficile by generating a 'mouse hospital' with conditions mimicking the human environment in which C. difficile is transmitted.

The results have implications for infection control measures in the healthcare environment and open the door for the development of treatments and improved diagnosis of C. difficile.

At present, healthcare professionals manage the threat of C. difficile by observing stringent hygiene and isolation practices primarily by dealing with patients who exhibit the symptoms of infection - including diarrhoea and fever. But today's publication suggests that widening the targets of infection control in hospitals, to include all patients receiving antibiotic treatment - although logistically complex - is worth investigating.

"C. difficile is a highly resistant and highly infectious pathogen and resistant to many front line antibiotics," explains Dr Trevor Lawley, Wellcome Trust Sanger Institute researcher and lead author on the study. "Until now, animal studies have focussed on the observable, acute symptoms of C. difficile. But, to understand how this highly infectious pathogen spreads, investigating the entire cycle of transmission is absolutely vital. We looked at mice carrying C. difficile and observed that they shed low levels of spores and, crucially, they did not infect other mice."

"But when we treated mice with antibiotics, we saw a dramatic rise in the levels of spores shed - leading to what we have described as a 'supershedder state' and transmission of C. difficile among mice. Importantly, transmission occurs even
'/>"/>

Contact: Don Powell
don@sanger.ac.uk
44-122-349-6928
Wellcome Trust Sanger Institute
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. Mass Biologic Labs/UMass Med School and Medarex license C. difficile monoclonal antibody to Merck
2. Scientists unlock the secrets of C. difficiles protective shell
3. Positive results in Phase 2 trial of treatment of C-difficile-associated diarrhea
4. When it comes fighting to C. difficile, the Palme dOr goes to soap and warm water
5. Curbing C. difficiles toxin production
6. In many fungi, reproductive spores are remarkably aerodynamic
7. Spread your sperm the smart way
8. Targeting children effective use of limited supplies of flu vaccine and could help control flu spread
9. Scientists examine perceptions of risk and the spread of disease
10. LSUHSC research describes function of key protein in cancer spread
11. Bacteria play role in preventing spread of malaria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... vessel returned to Spain culminating the around the world ... picture of how the global ocean works and what ... from the atmosphere is not limited to coastal areas, ... the planet, and it is already affecting the ocean ... in CSIC Residence for Researchers in Barcelona, in a ...
(Date:9/16/2014)... salmon-rich waters of Southeast Alaska to the white sand ... lumber and tourist towns, coastal residents around the U.S. ... divide along political lines. That,s a primary finding of ... published this month in the journal Society & ... environment-related differences from place to place to place. Each ...
(Date:9/16/2014)... are responsible for practically all vital functions in ... forward signals, transport particular substances and control immune ... proteins do not function independently of each other, ... examine the protein networks, you find many similarities ... from TUM,s Chair of Plant Systems Biology. "Some ...
Breaking Biology News(10 mins):The Malaspina Expedition confirms that pollution reaches even the most remote areas of the ocean 2The Malaspina Expedition confirms that pollution reaches even the most remote areas of the ocean 3Politics divide coastal residents' views of environment, UNH research finds 2Politics divide coastal residents' views of environment, UNH research finds 3Good networkers make prime targets 2
... Every process in a cell is affected by interactions ... body and their relationship to diseases is essential to ... Ontario Genomics Institute (OGI) is providing $100,000 through its ... Toronto (U of T),s Mammalian Membrane Two-Hybrid (MaMTH) project, ...
... Institution announced today that it is a grant recipient ... the Bill & Melinda Gates Foundation. Wolf B. ... with Bing Yang from Iowa State University and Frank ... health and development research project entitled "Transformative Strategy for ...
... recovery of UK butterfly populations to extreme drought is affected by ... in the landscape. The analysis, published this week in ... butterfly collected from 79 UK Butterfly Monitoring Scheme sites between 1990 ... 1995. The study was led by Dr Tom Oliver ...
Cached Biology News:Ontario Genomics Institute invests in validation of a novel protein interaction technology at U of T 2Carnegie Institution for Science receives Grand Challenges Explorations grant 2UK butterfly populations threatened by extreme drought and landscape fragmentation 2
(Date:9/16/2014)... N.C. , Sept. 16, 2014 ... heart failure compound has been shown to be effective ... results demonstrate an alternative to intravenous infusions that could ... prodrugs. The data were presented yesterday at the Heart ... Scientific Meeting in Las Vegas . ...
(Date:9/16/2014)... 16, 2014  The Council for Entrepreneurial Development ... in the country, today released a mid-year update ... It showed that in the first ... startups in the technology, life science, advanced ... from a variety of sources. Significant investment in technology ...
(Date:9/16/2014)... September 16, 2014 Convoy Therapeutics, ... and effective products to treat patients directly at ... a proprietary SPACEā„¢ Technology Platform announced today that ... will present at the White Hat Life Science ... Hyatt Regency Phoenix. In addition, interested individuals ...
(Date:9/16/2014)...  Ascendis Pharma A/S, a biotechnology company that ... unmet medical needs, today announced positive interim results ... evaluate once-weekly TransCon Growth Hormone in children with ... results will be presented at the 7th International ... held October 15-18, 2014, in Singapore.  ...
Breaking Biology Technology:Cardioxyl Presents Oral Heart Failure Treatment Data For Its Experimental HNO Prodrug At HFSA 18th Annual Scientific Meeting 2CED's Mid-Year Update to its Innovators Report Shows NC Startups Attracting Investment From Across the Globe with Several High-Profile Investment Deals, IPOs and Acquisitions Signaling Strength of Entrepreneurial Sector 2CED's Mid-Year Update to its Innovators Report Shows NC Startups Attracting Investment From Across the Globe with Several High-Profile Investment Deals, IPOs and Acquisitions Signaling Strength of Entrepreneurial Sector 3CED's Mid-Year Update to its Innovators Report Shows NC Startups Attracting Investment From Across the Globe with Several High-Profile Investment Deals, IPOs and Acquisitions Signaling Strength of Entrepreneurial Sector 4Convoy Therapeutics to Present at WhiteHat Investor Conference September 18, 2014 2Convoy Therapeutics to Present at WhiteHat Investor Conference September 18, 2014 3Ascendis Pharma A/S Announces Positive Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 2Ascendis Pharma A/S Announces Positive Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 3Ascendis Pharma A/S Announces Positive Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 4
... NeoGenomics, Inc. (OTC Bulletin Board: NGNM) today announced ... Equity Conference at 12:30 PM EDT on ... Hotel in Hollywood, FL.  Robert Gasparini, the Company,s ... NeoGenomics, market positioning, financial performance, and strategic direction and then ...
... /PRNewswire-Asia-FirstCall/ -- China-Biotics, Inc.,("China-Biotics", the "Company") (Nasdaq: CHBT ), the leading ... management will present at the Bank of America Merrill Lynch Health,Corporate Day. The ... Merrill,Lynch Client Service Center in Hong Kong . , ... About China-Biotics , ...
... ... The iuvo™ Chemotaxis Assay ... technology to provide quantitative measurements of neutrophil chemotaxis ( ... remains stable over the time period of the assay. ...
Cached Biology Technology:NeoGenomics to Present at Noble Financial's 6th Annual Equity Conference on Monday, June 7th 2NeoGenomics to Present at Noble Financial's 6th Annual Equity Conference on Monday, June 7th 3China-Biotics to Present at Bank of America Merrill Lynch Healthcare Event on June 22 2BellBrook Labs Launches Groundbreaking New Microplate for High Content Chemotaxis Assays in a Stable Gradient 2BellBrook Labs Launches Groundbreaking New Microplate for High Content Chemotaxis Assays in a Stable Gradient 3BellBrook Labs Launches Groundbreaking New Microplate for High Content Chemotaxis Assays in a Stable Gradient 4
... Human Pathogenic Viruses The ... (NCPV) preserves well characterised, authenticated ... secure facility, and NCPV is ... or nucleic acids derived from ...
... and easy to use Ascent ... all members of the Ascent ... a clear and easy-to-follow approach ... user-friendly and highly sophisticated data ...
Roll of Mesh 5m x 25cm...
... The Beacon 2000 Fluorescence Polarization ... basic research and assay development. Standard ... Beacon 2000 System uses a quartz-halogen ... range of 360-700 nm. It accommodates ...
Biology Products: