Navigation Links
Bypassing the insulin highway
Date:4/25/2008

An immune cell known as a neutrophil releases a protein that can suppress glucose production in the liver without targeting insulin, researchers have found.

Neutrophils, a type of white blood cell, produce special immune proteins called defensins which seem to have a connection with glucose levels. During bacterial infection, defensin production can increase dramatically, a rise that frequently results in hypoglycemia. In addition, many patients with type II diabetes have decreased defensin levels.

To study this connection further, Wenhong Cao and colleagues tested the effects of human defensin HNP-1 on both isolated cells and rodent models. Treating liver cells with HNP-1 suppressed the expression of several glucose-producing genes and decreased cellular glucose levels, but did not activate or alter the expression of the insulin receptor at all. This inhibition extended to animals, as HNP-1 reduced blood glucose levels in both normal mice and diabetic rats.

These findings provide some more information linking the immune system and metabolism, and also offer a new avenue to target diabetics who do not respond well to traditional insulin-based treatments.


'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1

Related biology news :

1. Insulins brain impact links drugs and diabetes
2. Botched production of insulin molecule may lead to diabetes
3. Drug could improve pregnancy outcomes in wider range of women with insulin resistance
4. Sugary drinks, not fruit juice, may be linked to insulin
5. New research reveals shark superhighways and hotspots
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... -- NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" ... of independent Directors Mr. Robin D. Richards and ... furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer ... guidance and benefiting from their considerable expertise as we move ...
(Date:4/5/2017)... , April 5, 2017  The Allen Institute for ... Cell Explorer: a one-of-a-kind portal and dynamic digital window ... imaging data, the first application of deep learning to ... stem cell lines and a growing suite of powerful ... for these and future publicly available resources created and ...
(Date:4/5/2017)... KEY FINDINGS The global market for stem ... 25.76% during the forecast period of 2017-2025. The rise ... growth of the stem cell market. Download ... The global stem cell market is segmented on the ... cell market of the product is segmented into adult ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... ... 2017 , ... Any expert in stem cell research or stem cell medicine ... half a century. Despite their essential roles in human health and regenerative medicine, ... tags developed for this purpose also tag other, more abundant, non-stem tissue cells ( ...
(Date:8/15/2017)... Ca (PRWEB) , ... August 15, 2017 , ... ... production and is threatened by various biotic and abiotic factors. During this educational ... evolutionary history of coffee, as well as gain a better understanding of how ...
(Date:8/14/2017)... (PRWEB) , ... August 14, 2017 , ... ... provide essential device-to-computer interconnect using USB or PCI Express, announced the release of ... SYZYGY is intended to satisfy the need for a compact, low cost, low ...
(Date:8/11/2017)... ... ... A staple in the community for more than 60 years, Bill Miller ... a new digital marketing strategy and updated logo. , As part of the initiative ... the South Texas Blood & Tissue Center for the month of August. , ...
Breaking Biology Technology: