Navigation Links
Bypassing the insulin highway
Date:4/25/2008

An immune cell known as a neutrophil releases a protein that can suppress glucose production in the liver without targeting insulin, researchers have found.

Neutrophils, a type of white blood cell, produce special immune proteins called defensins which seem to have a connection with glucose levels. During bacterial infection, defensin production can increase dramatically, a rise that frequently results in hypoglycemia. In addition, many patients with type II diabetes have decreased defensin levels.

To study this connection further, Wenhong Cao and colleagues tested the effects of human defensin HNP-1 on both isolated cells and rodent models. Treating liver cells with HNP-1 suppressed the expression of several glucose-producing genes and decreased cellular glucose levels, but did not activate or alter the expression of the insulin receptor at all. This inhibition extended to animals, as HNP-1 reduced blood glucose levels in both normal mice and diabetic rats.

These findings provide some more information linking the immune system and metabolism, and also offer a new avenue to target diabetics who do not respond well to traditional insulin-based treatments.


'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1

Related biology news :

1. Insulins brain impact links drugs and diabetes
2. Botched production of insulin molecule may lead to diabetes
3. Drug could improve pregnancy outcomes in wider range of women with insulin resistance
4. Sugary drinks, not fruit juice, may be linked to insulin
5. New research reveals shark superhighways and hotspots
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)...  When it comes to technology, healthcare is usually one of ... However, when it comes to wearables, healthcare is trying to move ... Internet of Things and its wearable cousins is less than mature, ... industry, whether it,s in the hospital for a major procedure or ... With that in mind, InformationWeek editor Rodney Brown ...
(Date:7/29/2014)... of Kent has shown for the first time how ... that could have a major impact on cancer therapy ... uncovered the mechanism whereby the physical properties of the ... are ,fine-tuned, to undertake different functions. , While ... providing a framework for the cell, others are more ...
(Date:7/29/2014)... for parents of preterm babies latest research from the ... they become teenagers, the brains of many preterm children can ... A study conducted by the University,s Robinson Research Institute ... experiences no brain injury in early life, their cognitive abilities ... term-born peers. , However, the results of the study, published ...
Breaking Biology News(10 mins):Preterm children's brains can catch up years later 2
... involved in cellular immune signaling, scientists have succeeded in making ... protein with a new twist may eventually be used to ... involved in immune responses that are initiated by proteins called ... the immune system in response to challenges by foreign agents ...
... properties of human bone has been made by scientists ... scientists describe their results –?finding a sort of "glue" ... August issue of the international scientific journal, Nature Materials. ... It describes how healthy bone resists fracture and how ...
... Georgia Institute of Technology and the John Innes Centre ... which disease-causing bacteria may thwart the body's natural defense ... development of more effective antibiotics, appear in the September ... oxide is produced by the body to fight infections. ...
Cached Biology News:Engineered molecule amplifies body's immune response 2Engineered molecule amplifies body's immune response 3Fundamental discovery -- Bone fracture 2Fundamental discovery -- Bone fracture 3Researchers uncover E. coli's defense mechanism 2
(Date:7/29/2014)... (PRWEB) July 29, 2014 The first ... a next generation approach to robotics. What sets Droidles ... patent pending technology that allows them to communicate, share ... wirelessly over the internet. , “The invention is the ... the little Droidles a life of their own, both ...
(Date:7/29/2014)... 2014 EXpressLO LLC, expert provider of ... preparation solutions, has been granted patent number 8,789,826 by ... methods incorporating a unique specimen carrier support grid design ... second company patent for EXpressLO LLC awarded to founder ... These complementary patents extend EXpressLO’s portfolio of intellectual property. ...
(Date:7/28/2014)... 2014 “2014 Deep Research ... is a professional and in-depth research report ... report introduces Lubricant basic information, including Lubricant ... and industry overview. This research covers the ... as well as global industry analysis covering ...
(Date:7/28/2014)... July 28, 2014 ... Identification Market by Products (Consumables, Instruments, Services), Methods (Phenotypic, ... User (Detection, Characterization) - Global Forecasts to ... Market is estimated at $896.5 Million in ... Million by 2019, growing at a CAGR ...
Breaking Biology Technology:Droidles, the Social Network of Robots and Open Source Platform for the Internet of Things, Launches for Crowd Funding on IndieGoGo.com 2EXpressLO LLC Granted Second U.S. Patent for Innovative Specimen Preparation Methods 2Lubricant Market & Adhesion Promoter Industry (Globa, China) Analysis Now Available at DeepResearchReports.com 2Lubricant Market & Adhesion Promoter Industry (Globa, China) Analysis Now Available at DeepResearchReports.com 3Lubricant Market & Adhesion Promoter Industry (Globa, China) Analysis Now Available at DeepResearchReports.com 4Microbial Identification Market worth $1,194.1 Million by 2019 2Microbial Identification Market worth $1,194.1 Million by 2019 3
... Cell Therapeutics, Inc.,(CTI) (Nasdaq and MTAX: CTIC) ... (the "Letter") from Nasdaq indicating that the Company,s,recently ... Preferred,Stock (the "Series C Preferred") and warrants did ... Nasdaq Marketplace Rule 4351 and IM 4351.,The Nasdaq ...
... Plan Extends Financial Resources Beyond 2008 -, ... Inc. (Nasdaq: SNSS ) today announced that ... and implementing a revised,operating plan that focuses its ... while streamlining the company,s operations and extending,its financial ...
... for Early and Accurate Diagnosis of Peripheral Artery ... Disease ... - Findings Published Online in Circulation -, FREMONT, Calif., Aug. 28 ... research that details how a protein biomarker called beta-2,microglobulin may aid in the ...
Cached Biology Technology:Cell Therapeutics, Inc. Takes Corrective Actions in Response to Nasdaq Determination 2Sunesis Pharmaceuticals Announces Reorganization to Focus Resources and Build Value in Clinical-Stage Programs 2Sunesis Pharmaceuticals Announces Reorganization to Focus Resources and Build Value in Clinical-Stage Programs 3Sunesis Pharmaceuticals Announces Reorganization to Focus Resources and Build Value in Clinical-Stage Programs 4Vermillion and Collaborators Discover Protein Biomarker Associated with Peripheral Artery Disease 2Vermillion and Collaborators Discover Protein Biomarker Associated with Peripheral Artery Disease 3
Purified anti-DNA-PKcs Phosphorylated (Thr2609)...
Purified anti-PI3K p110 delta...
Biotin anti-mouse Ly-49C/F/I/H...
... Purified Tyrosine Hydroxylase (Ser40) Polyclonal ... raised against synthetic phosphopeptide corresponding ... the phospho-Ser40 of rat Tyrosine ... purified by sequential chromatography on ...
Biology Products: