Navigation Links
Bypassing the insulin highway
Date:4/25/2008

An immune cell known as a neutrophil releases a protein that can suppress glucose production in the liver without targeting insulin, researchers have found.

Neutrophils, a type of white blood cell, produce special immune proteins called defensins which seem to have a connection with glucose levels. During bacterial infection, defensin production can increase dramatically, a rise that frequently results in hypoglycemia. In addition, many patients with type II diabetes have decreased defensin levels.

To study this connection further, Wenhong Cao and colleagues tested the effects of human defensin HNP-1 on both isolated cells and rodent models. Treating liver cells with HNP-1 suppressed the expression of several glucose-producing genes and decreased cellular glucose levels, but did not activate or alter the expression of the insulin receptor at all. This inhibition extended to animals, as HNP-1 reduced blood glucose levels in both normal mice and diabetic rats.

These findings provide some more information linking the immune system and metabolism, and also offer a new avenue to target diabetics who do not respond well to traditional insulin-based treatments.


'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1

Related biology news :

1. Insulins brain impact links drugs and diabetes
2. Botched production of insulin molecule may lead to diabetes
3. Drug could improve pregnancy outcomes in wider range of women with insulin resistance
4. Sugary drinks, not fruit juice, may be linked to insulin
5. New research reveals shark superhighways and hotspots
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/18/2016)... 2016 --> --> ... Manned & Unmanned Vehicles, Physical infrastructure and Perimeter Surveillance & ... the border security market and the continuing migration crisis in ... Europe has led visiongain to publish this unique ... --> defence & security companies in the border ...
(Date:3/15/2016)... Yissum Research Development Company of the Hebrew University ... University, announced today the formation of Neteera Technologies ... biological indicators. Neteera Technologies has completed its first round ... Neteera,s ... from sweat ducts, enables reliable and speedy biometric identification, ...
(Date:3/11/2016)... http://www.apimages.com ) - --> http://www.apimages.com ) - ... Images ( http://www.apimages.com ) - Germany . ... new refugee identity cards. DERMALOG will be unveiling this device, and ... Hanover next week.   --> Germany ... the new refugee identity cards. DERMALOG will be unveiling this device, ...
Breaking Biology News(10 mins):
(Date:5/4/2016)... ... May 04, 2016 , ... Proove Biosciences, Inc. , ... strategic partnership with McGill University . The partnership is designed to advance research ... order to help patients in pain. With the new agreement, researchers at Proove Biosciences ...
(Date:5/4/2016)... ... May 04, 2016 , ... Nutrafol®, a first-to-market smart-supplement for ... and stress related hair loss. With patent-pending formulas for both female hair loss ... in the medical and salon channels nationwide. , Dermatologists, Plastic Surgeons and ...
(Date:5/3/2016)... ... May 03, 2016 , ... Flagship Biosciences, the leader ... to its Board of Directors. Dr. Gillett recently retired from Charles River Laboratories ... and Chief Scientific Officer. A board-certified veterinary pathologist, Dr. Gillett joined Charles River ...
(Date:5/3/2016)... NY (PRWEB) , ... May 03, 2016 , ... According ... Hospital , for definitive prostate cancer treatment, patients traditionally had two main treatment options: ... treatment plan would be made. , New technology has enabled doctors to administer ...
Breaking Biology Technology: