Navigation Links
Building better blood vessels could advance tissue engineering
Date:4/4/2013

lls, which make up the vessel lining and supporting cells. Their scaffolding carrier is fibrin, a protein in the human body that helps blood clot.

"The cells know what to do," Putnam said. "You can take these things and mix them and put them in an animal. Literally, it's as easy as a simple injection and over a few days, they spontaneously form new vessels and the animals' own vasculature connects to them."

But it turns out these vessels don't always thrive. The U-M team aimed to figure out why. In reading previously published findings, Putnam noticed that researchers used "a mishmash of support cells," and the field had paid little attention to which ones work best. So that's where he and his colleagues focused.

In their experiments, they mixed three recipes of blood vessel starter solutions, each with a different commonly used supporting cell type: lung fibroblasts, adult stem cells from fat and adult stem cells from bone marrow. They also made a version with no supporting cells at all. They injected each solution under the skin of mice, and allowed the new blood vessels to form over a period of two weeks. At various points in time, they injected a tracer dye into the animals' circulation to help them see how well the engineered capillaries held blood, and whether they were connected to the animals' existing vessel networks.

The researchers found that the solution with no support cells and the one with the lung fibroblasts produced immature, misshapen human capillaries that leaked. They could tell because the tracer dye pooled in the tissue around the new vessels. On the other hand, the solutions with both types of adult stem cells gave rise to robust human capillaries that kept blood and dye inside them.

The paper notes that one popular method biomedical engineers use to check the success of their effortscounting blood vesselsmight not be an ideal measure. The adult stem cell solutions produced fewer blood vessels th
'/>"/>

Contact: Nicole Casal Moore
ncmoore@umich.edu
734-647-7087
University of Michigan
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Building the European Unions Natura 2000 -- the largest ever network of protected areas
2. New study finds a protein combination is best to consume post-workout for building muscle
3. Light weights are just as good for building muscle, getting stronger, researchers find
4. CUNY Energy Institute battery system could reduce buildings electric bills
5. A cells first steps: Building a model to explain how cells grow
6. Stealing lifes building blocks
7. Blood-brain barrier building blocks forged from human stem cells
8. Building global collaboration for biodiversity intelligence
9. Mathematicians find solution to biological building block puzzle
10. Minimally invasive building renovation
11. Natural regeneration building urban forests, altering species composition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2015)... , May 20, 2015 NXT-ID, Inc. (NASDAQ: ... its wholly owned subsidiary, 3D-ID LLC, a company engaged ... Battelle for the biometrics technology portion of the recently ... from the Department of the Army. 3D-ID ... developed for government, law enforcement and security agencies. ...
(Date:5/19/2015)... 2015  Technology is rapidly advancing, outpacing enterprises, ability ... cloud. Passwords and their management are soon to be ... specifications such as those developed by the FIDO Alliance™. ... presents for BYOD, COPE, IoT, and mobile payments, the ... In response to the call for ...
(Date:5/18/2015)... , May 18, 2015 Fingerprint Cards ... FPC1020, FPC1025, FPC1145, FPC1155 and FPC1035 from one if its ... until and including Q3 2015 and the sensors will be ... Communicated order values for 2015 hereby amount to 740 MSEK ... 2015 of 140 MSEK and a number of smaller orders ...
Breaking Biology News(10 mins):NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 2NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 3HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 2HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2
... themselves during leisurely deep-sea diving trips and not from resurfacing ... bone deformities on the fossilized remains of Ichthyosarians , ... million years ago. The lesions were similar to ... body pressure, and suggest the reptiles suffered from a version ...
... A new report by U.S. and Canadian scientists analyzes ... the Northeast has changed and is likely to change ... on multiple aspects of forests in the northeastern corner ... with recommendations on adaptive and mitigating strategies for dealing ...
... - Bureau of Reclamation Commissioner Michael L. Connor ... $1.2 million, and Reclamation will partner with other ... projects to benefit the Desert and Southern Rockies ... to provide more than $3.5 million for these ...
Cached Biology News:'Dinosaur bends' caused by prolonged diving 2Climate change effects, potential mitigation in Northeast forests subject of Forest Service Report 2WaterSMART funds $1.7 million for science projects in desert and southern Rockies LCCs 2WaterSMART funds $1.7 million for science projects in desert and southern Rockies LCCs 3
(Date:6/2/2015)... 2, 2015  Alere Inc. (NYSE: ALR ... the White House Antibiotic Stewardship Forum today to ... and advance the President,s National Action Plan to ... number of measurable goals and objectives over the ... healthcare providers protect their patients through antibiotic stewardship, ...
(Date:6/2/2015)... Sunnyvale, CA (PRWEB) June 02, 2015 ... their official United States distributor for the Moenninghoff ... Finger stated, “I am pleased to announce that the ... U.S. market. For our firm, founded in 1916, this ... that R.M. Hoffman is the kind of professional distributor ...
(Date:6/1/2015)... 2015 Research and ... addition of the "Oxidative Stress Assay ... Type (Indirect, Enzyme-based, Reactive Oxygen Species (ROS)-based), ... - Global Forecast to 2020" report ... http://photos.prnewswire.com/prnh/20130307/600769) , The global oxidative ...
(Date:6/1/2015)... About Bio-alcohols Bio-alcohols are ... cellulose. Bio-alcohols are primarily used in the transportation sector. ... for gasoline in cars. Technavio,s analysts forecast the global ... percent over the period 2014-2019. Covered ... segmented into five: transportation, infrastructure, medical, and others. Technavio,s ...
Breaking Biology Technology:Alere Announces Broad Initiatives to Help Combat Antibiotic Resistance during White House Antibiotic Stewardship Forum 2R.M. Hoffman Company designated official United States distributor for the Moenninghoff product line. 2R.M. Hoffman Company designated official United States distributor for the Moenninghoff product line. 3Oxidative Stress Assay Market 2015 - Global Forecast to 2020 2Global Bio-alcohols Market 2015-2019 2
... DALLAS , July ... report "Bioinformatics Market - Advanced Technologies, Global,Forecast and Winning ... bioinformatics market is,expected to reach a $8.3 billion ... from,2009-2014. While knowledge management formed the largest submarket is ...
... Dr. Woo Young Lee of the Chemical Engineering ... Wang of Chemistry, Chemical Biology and Biomedical Engineering ... significant NSF funding for their research entitled, "Evaporative ... award is a reflection of the pioneering work ...
... HOPKINTON, Mass. , July 20 Caliper Life Sciences, ... company,s second quarter 2010 financial results at 9:00 a.m. ET ... Officer and Peter McAree , Chief Financial Officer, will host the ... for the future. , , ...
Cached Biology Technology:MarketsandMarkets: Global Bioinformatics Market Worth $8.3 billion by 2014 2MarketsandMarkets: Global Bioinformatics Market Worth $8.3 billion by 2014 3MarketsandMarkets: Global Bioinformatics Market Worth $8.3 billion by 2014 4NSF funds infection-resistant orthopedic research 2Caliper Life Sciences' Second Quarter 2010 Financial Results Conference Call Notice 2
Artisan™ Wash Solution (x 50) Additional Information: EU regulatory status: CE US regulatory status: IVD ...
MiniCycler thermal cycler with Hot Bonnet heated lid, holds 25x0.2ml tubes...
... RNA stain is used to stain and ... agarose gels and does not interfere with ... nm transilluminator, the stain emits a red-orange ... film or with a CCD camera-based gel ...
... mitochondrial transmembrane potential is one ... that occur following induction of ... Kit utilizes a lipophilic cation, ... mitochondrial activity marker. MitoLight partitions ...
Biology Products: