Navigation Links
'Buckyballs' to treat multiple sclerosis
Date:3/19/2009

If you're of a certain age, you'll remember Buckminster Fuller's distinctive "geodesic domes" soccer-ball-shaped structures that the late futurist envisioned as ideal human domiciles. Tel Aviv University chemists remember them too and are now putting them to use in the treatment of multiple sclerosis (MS).

In partnership with a group of Prof. Howard Weiner from Brigham and Women's Hospital at Harvard Medical School, Dr. Michael Gozin from TAU's School of Chemistry is attempting to create the next generation MS drug based on a delivery platform of "buckyballs," small soccer-ball-shaped molecules sometimes called fullerenes. Made from pure carbon, the buckyballs can function as invigorating antioxidants to keep neurons in the brain alive and kicking.

There is currently no cure for MS, which slowly paralyzes and then kills.

Buckyballs and related carbon nanotubes have enormous potential to be used in sensors and electronic applications allowing scientists to manufacture much more smaller and faster processors. These carbon-based materials have a huge range of possibilities in nanotechnology applications as well.

Until now, buckyball-derived therapeutics have not been used in medicine. But the TAU and Harvard teams believe that they may resolve issues related to this nanomaterial development, and are seeking to commercialize their patented invention. If successful, the TAU-Harvard collaboration could provide new hope to millions of MS sufferers, and would make Bucky himself proud.

On the Medicine Ball

The TAU team is the first in the world to have synthesized a brain-targeted antioxidant to treat affected neurons in the brain. Pre-clinical trials, the researchers report, proved successful in animal models. They are also attempting to apply the same technology to the treatment of Alzheimers disease, but a reliable and effective treatment for MS is their primary goal.

MS is an autoimmune disease that robs people of the ability to control their motor movements. No one knows exactly how many people are afflicted with MS. According to the National Institute of Neurological Disorders and Stroke, it is estimated that there are currently more than 350,000 people in the United States, who have been diagnosed with MS, where approximately 200 new cases are diagnosed each week. Current state-of-the-art therapies like the Israeli-invented Copaxone clearly help, but may not be enough, says Dr. Gozin, whose wide-ranging research has included work on classified projects for the U.S. Department of Defense.

"Multiple sclerosis is a very serious clinical condition," says Dr. Gozin. "I had a dream, an idea for a new kind of drug." He took this idea to MS expert Prof. Howard Weiner at Harvard University, and the two began a collaboration.

"I wanted to target with antioxidants specific receptors in the brain, which are involved in the disease progress, to stall the deterioration of motor function in MS sufferers," Dr. Gozin says. The US-Israeli researchers started from the belief that buckyballs, and brain-targeted moieties attached to them, may be able to achieve success in treating MS.

A Dose of C60

"We've created a molecule based on the C60 fullerene, a soccer-ball-shape, with great biomedical potential," says Dr. Gozin. The Tel Aviv University team, including graduate student Amnon Bar-Shir, was the first to synthesize and patent this application, which is "programmed" to target specific receptors in the brain. "We are presently working on the next generation of this type of molecules, containing less exotic and more natural building blocks," Dr. Gozin reports.


'/>"/>

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert  

Related biology news :

1. Tiny buckyballs squeeze hydrogen like giant Jupiter
2. Manufactured Buckyballs dont harm microbes that clean the environment
3. Buckyballs have high potential to accumulate in living tissue
4. Nicotinic receptors may be important targets for treatment of multiple addictions
5. A new radiation therapy treatment developed for head and neck cancer patients
6. Restoring sight, advances in fertility treatments and better visibility for pilots at FIO
7. Gamma globulin effective in treating eye infections caused by adenoviruses
8. Presence of gene mutation helps guide thyroid cancer treatment
9. U of M begins nations first clinical trial using T-reg cells from cord blood in leukemia treatment
10. New genetic research into nicotine addiction shows promise for personalized treatment
11. Doctors learn to control their own brains pain responses to better treat patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Buckyballs' to treat multiple sclerosis
(Date:3/9/2017)... and MOUNTAIN VIEW, Calif. , March ... Made Simple," and 23andMe , the leading personal ... food choices.  Zipongo can now provide customers with personalized ... health goals and biometrics, but also genetic markers impacting ... Zipongo,s personalized food decision support platform uses ...
(Date:3/6/2017)... MATEO, Calif. , March 6, 2017 /PRNewswire/ ... marketing and sales technology, today announced Predictive Sales ... solution for infusing actionable sales intelligence into Salesforce. ... to automatically enable their sales organizations with deep ... messages that allow for intelligent engagement. Predictive Sales ...
(Date:3/2/2017)... , March 2, 2017 Who risk ... lawsuits? Download the full report: https://www.reportbuyer.com/product/4313699/ ... THE FINGERPRINT SENSOR FIELD? Fingerprint sensors using capacitive ... The fingerprint sensor vendor Idex forecasts an increase of ... mobile devices and of the fingerprint sensor market between ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... March 22, 2017 Good Start Genetics, a ... eclipsed the 130 million covered lives mark through its ... Texas . With newly signed contracts ... to enjoy strong payor acceptance based on the quality ... and genetic counseling, its industry-leading customer care and support ...
(Date:3/22/2017)... BEACH, Florida , March 22, 2017 ... ... for various cancer conditions are being pressured as of late ... therapy for cancer pain management has a dramatic impact on ... up research and development activities for identifying new forms of ...
(Date:3/22/2017)... ... ... Premier executive recruitment firm, Slone Partners, is proud to have been named ... , Hunt Scanlon Media is one of the most respected life science publications ... human capital sector. , “It is a great honor for Slone Partners to be ...
(Date:3/22/2017)... Diego, Calif. (PRWEB) , ... March 21, 2017 ... ... on Kickstarter , more than tripling its goal and raising over $30,000 ... low-maintenance vertical garden that grows nutritious veggies & herbs fast, easy, and affordably, ...
Breaking Biology Technology: