Navigation Links
Brown licenses potential muscular dystrophy treatment to Tivorsan Pharmaceuticals
Date:9/21/2010

w treatment in DMD. If biglycan proves safe and effective in human testing, the potential exists for providing relief to thousands of boys and their families around the world."

Fallon serves as chair of Tivorsan's scientific advisory boaard.

Developing biglycan

In 2000 a team led by Fallon began to accumulate evidence that biglycan, which is produced naturally in the body, regulates the production of a protein called utrophin. Utrophin, discovered in 1989, stimulates the body to repair muscle damage, just like dystrophin, the protein that DMD-afflicted boys are genetically unable to produce.

All young children produce utrophin, but they produce much less of it naturally as they get older.

"In normal individuals that's fine because dystrophin is there, but in a Duchenne boy there is no hand-off," Fallon said. "The baton is dropped."

That dropped hand-off helps explain why DMD doesn't begin to show up in boys until they are preschoolers and why they still retain enough strength to walk on their own until they are preteens.

Further research by Fallon and research associate Beth McKechnie revealed that biglycan is rare in its class of proteins because the physiologically active form can be manufactured relatively easily using recombinant lab techniques. In the last several years, Fallon's research group, including former research associate Mary Lynn Mercado and current research associates Alison Amenta and Michelle Dechene, have been testing and refining the use of biglycan in DMD mice.

Partners prepared to fight

The research has gone well enough that last year Fallon won a four-year, $5.2-million grant from the National Institutes of Health to advance the development of biglycan as a novel potential therapy.

Fallon also won funding from foundations dedicated to fighting DMD. Last year Parent Project Muscular Dystrophy awarded him its End Duchenne Award. Charley's Fun
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
410-863-1862
Brown University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Little brown balls tie malaria and algae to common ancestor: UBC research
2. Are invasives bad? Not always, say Brown researchers
3. Brown geologists show unprecedented warming in Lake Tanganyika
4. Brown scientists elected to American Academy of Arts and Sciences
5. Brown biologist solves mystery of tropical grasses origin
6. Brown fat cells make spare tires shrink
7. Brown and beige dominate the plate: Daily dose of color needed to fill Americas phytonutrient gap
8. Northern brown bears discovered feeding on whitefish runs
9. New research to unravel how nutrients drive toxic brown tides on East Coast
10. Brain-computer interface, developed at Brown, begins new clinical trial
11. Cold and brown fat raise the prospect of a new method of treating obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... marginal division of the striatum is also involved ... degree of substance P in the striatal marginal ... and his team, College of Biophotonics, South China ... substance P receptor, neurokinin 1 was highly expressed ... normal rats. Unilateral or bilateral injection of an ...
(Date:7/11/2014)... 2014 Research and Markets has ... Market - Industry Analysis Size Share Growth Trends and ... http://photos.prnewswire.com/prnh/20130307/600769 The ... a need for high level security in both private ... such as username and passwords, tokens etc. are vulnerable ...
(Date:7/10/2014)... and other major cities in New Mexico, nearly every ... wastewater rather than precious potable water supplies. Across the ... all golf courses receive treated effluent. Reusing the effluent ... golf courses and homeowners alike fertilize their lawns during ... nitrate. A New Mexico State University turfgrass expert has ...
Breaking Biology News(10 mins):International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019 2'Tailored' water -- the latest in lawn care 2
... largest study of migraines, researchers have found 5 genetic regions ... onset of migraine. This study opens new doors to understanding ... The team identified 12 genetic regions associated with migraine susceptibility. ... known to play a role in controlling brain circuitries and ...
... study shows that the predator-prey relationship can affect the ... influence on the environment may offer a new way ... climate change. The study, conducted by researchers ... comes out this week in the Proceedings of ...
... - 250 million years ago, a mammal forerunner and ... Africa, Australia and France have discovered a world first ... burrow from the Karoo Basin of South Africa. ... and fossilized after being trapped by a flash flood ...
Cached Biology News:Getting to grips with migraine 2New study shows predators affect the carbon cycle 2Oddest couple ever found 2Oddest couple ever found 3Oddest couple ever found 4
(Date:7/10/2014)... 2014 EvoDerma ’s NOOME Anti-Aging Motion ... device now comes with a second treatment cup to help ... The new cup is thinner on the edges for a ... rough, thin and uneven surfaces on the face, neck and ... stimulating treatment on areas such as the cheeks and neck, ...
(Date:7/10/2014)... DALLAS , July 10, 2014  Kainos Capital, ... consumer brands, today announced that it has acquired the ... stake in the business. Terms of the transaction were ... loss and meal replacement business that markets ready-to-drink shakes, ... North America and in the ...
(Date:7/10/2014)... -- According to the International Atomic Energy Agency ... from terrorists acquiring sufficient quantities of plutonium or ... nuclear explosive device. The IAEA also notes that ... gram-level quantities, which can be challenging to detect ... new study appearing this week in the ...
(Date:7/10/2014)... disorders has been extremely challenging because there are many ... to cause disease. Now investigators reporting in the July ... Stem Cell describe a strategy that may help ... risk factors or environmental exposures to affect the development ... variant that may predispose individuals to schizophrenia. , ...
Breaking Biology Technology:Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion 2Kainos Capital Acquires Slim-Fast From Unilever 2Sensitive detection method may help impede illicit nuclear trafficking 2New strategy could uncover genes at the root of psychiatric illnesses 2
... 25 /Xinhua-PRNewswire-FirstCall/ -- China Medical,Technologies, Inc. (the ... China-based,medical device company that develops, manufactures and ... focused ultrasound tumor,therapy systems, today announced adjustment ... outstanding 3.5% Convertible Senior Subordinated,Notes due November ...
... Goods Raises Questions about SIGG and Recommends Greener Bottle , ... Concord, ... picture of Cindy Crawford or Madonna, they,re probably sipping water from a ... honor but, sadly, it may not be that green," said Debby de ...
... Coherent, Inc.,(Nasdaq: COHR ), today announced the Company ... host a live webcast to discuss its third,fiscal quarter ... p.m. ET., The call will be broadcast live ... http://www.coherent.com/Investors/ or http://www.earnings.com .,For those who are ...
Cached Biology Technology:China Medical Technologies Adjusts Conversion Rate of Convertible Notes 2SIGG Water Bottles: Hip But Not Necessarily Green; Were Madonna and Cindy Crawford Hoodwinked? 2
... Western Blot Strong Antibody Stripping Solution is ... blots that have been developed with chemiluminescence ... is not recommended for stripping colorimetric substrates ... not possible to effectively remove substrates that ...
... Helios gene gun low-pressure system, 100-120 V, ... biomaterials into cells. The system includes the ... regulator, tubing prep station, syringe kit, tubing ... regulator, and instructions. The dimensions of the ...
... The 500 optimization kit is for fine-tuning ... interest. The kit is recommended when you ... system. The kit includes 0.25 g each ... micrometer diameter gold microcarriers, 100 each of ...
... can be used to test the crossreactivity ... sera that are commonly used as blocking ... spots for 21 different protein preparations on ... crossreactivity and species specificity, QC of purified ...
Biology Products: