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Brown chemist finds gray mold's killer gene
Date:12/1/2008

duction of botrydial. They then sought to learn how this cluster manufactures the chemical agent and which of the genes was the mastermind in the production.

The culprit is an enzyme called a sesquiterpene cyclase, Cane's laboratory found.

"The metabolic pathways for creating organic compounds typically involve gene clusters, like a package," Cane explained. "One great advantage to our investigation is that if you find one, you look to the left or to the right, and you find the others."

In laboratory tests, Cane and the team introduced a mutant gene that deleted the sesquiterpene cyclase, which completely abolished production of the toxin.

"This means that if you can inhibit the enzyme from this pathway, you can eliminate this toxin," Cane said.

The team now is working on a similar procedure to tackle a strain of Botrytis cinerea that is able to produce both botrydial and a second toxin that it uses to attack its plant targets.


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Contact: Richard Lewis
Richard_Lewis@Brown.edu
401-863-3766
Brown University
Source:Eurekalert  

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Brown chemist finds gray mold's killer gene
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