Navigation Links
Brothers in arms: Commensal bacteria help fight viruses
Date:6/18/2012

PHILADELPHIA Healthy humans harbor an enormous and diverse group of bacteria and other bugs that live within their intestines. These microbial partners provide beneficial aid in multiple ways from helping digest food to the development of a healthy immune system. In a new study published online in the journal Immunity, David Artis, PhD, associate professor of Microbiology, and Michael Abt, PhD, a postdoctoral researcher in the Artis lab, Perelman School of Medicine, University of Pennsylvania, show that commensal bacteria are also essential to fight off viral infections.

"From our studies in mice, we found that signals derived from these beneficial microbes are essential for optimal immune responses to experimental viral infections," says Artis. "In one way we could consider these microbes as our 'brothers in arms' in the fight against infectious diseases." Artis is also an associate professor of Pathobiology in the Penn School of Veterinary Medicine.

Signals from commensal bacteria influence immune-cell development and susceptibility to infectious or inflammatory diseases. Commensal microbial communities colonize barrier surfaces of the skin, vaginal, upper respiratory, and gastrointestinal tracts of mammals and consist of bacteria, fungi, protozoa, and viruses. The largest and most diverse microbial communities live in the intestine.

Previous studies in patients have associated alterations in bacterial communities with susceptibility to diabetes, obesity, cancer, inflammatory bowel disease, allergy, and other disorders. Despite knowing all of this, exactly how commensal bacteria regulate immunity after being exposed to pathogens is not well understood.

To get a better picture of how these live-in bacteria are beneficial, the Artis lab used several lines of investigation. First, they demonstrated that mice -- treated with antibiotics to reduce numbers of commensal bacteria -- exhibit an impaired antiviral i
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Intestinal bacteria produce neurotransmitter, could play role in inflammation
2. Normal bacterial makeup has huge implications for health, says CU professor
3. Consortium of scientists maps the human bodys bacterial ecosystem
4. More than 1 way to be healthy: Map of bacterial makeup of humans reveals microbial rare biosphere
5. IU role in Human Microbiome Project exposes battle history between bacteria, viruses in human body
6. The activity of a bacterial effector protein seen in molecular detail
7. Light-induced delivery of nitric oxide eradicates drug-resistant bacteria
8. Arctic bacteria help in the search to find life on moon Europa
9. Nowhere to hide: New device sees bacteria behind the eardrum
10. Fighting bacterias strength in numbers
11. Agricultural bacteria: Blowing in the wind
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Brothers in arms: Commensal bacteria help fight viruses
(Date:7/14/2014)... than 140 years ago, Charles Darwin noticed something peculiar ... species are more tame, and they also tend to ... ears, patches of white fur, and more juvenile faces ... this pattern has proved elusive, but now, in a ... a new hypothesis has been proposed that could explain ...
(Date:7/14/2014)... at the University of East Anglia have shown how ... growth in cancer patients. , Research published today ... are responsible for the drug,s success in shrinking tumours. ... help develop a synthetic equivalent with anti-cancer properties. ... Complutense de Madridin, Spain. The team used samples of ...
(Date:7/14/2014)... researchers have developed a technology that could overcome ... fuel a fuel that could replace expensive ... technology is a novel catalyst that performs almost ... reactions, which use electric currents to split water ... is also far more efficient than less-expensive catalysts ...
Breaking Biology News(10 mins):Domestication syndrome: White patches, baby faces and tameness 2UEA research reveals how cannabis compound could slow tumour growth 2Rutgers chemists develop technology to produce clean-burning hydrogen fuel 2
... LA JOLLA, CA---- Researchers at the Salk Institute for Biological ... skin cells and turned them into induced pluripotent stem cells ... form any other cell or tissue in the body. ... Shinya Yamanaka at Kyoto University in Japan, and human iPSCs ...
... Calif.) It happens in military units, street gangs ... cultures, the rituals mark the transition from adolescence to ... given. With a long history of seemingly universal ... puzzle. Why have so many cultures incorporated it into ...
... market to treat leukemia reversed symptoms of colitis in lab ... the University of Alberta. Faculty of Medicine & Dentistry ... journal, PLOS ONE . His team ... role in the development of colitis. When this gene quits ...
Cached Biology News:Induced pluripotent stem cells reveal differences between humans and great apes 2Induced pluripotent stem cells reveal differences between humans and great apes 3UCSB anthropologist examines the motivating factors behind hazing 2UAlberta medical researchers discover potential new treatment for colitis 2UAlberta medical researchers discover potential new treatment for colitis 3
(Date:7/14/2014)... Mass. , July 14, 2014 Minerva ... the development of new therapies to treat neuropsychiatric diseases ... has been appointed vice president of finance and ... Mr. Ahlholm is a senior executive with more than ... at technology and life science companies. His background includes ...
(Date:7/14/2014)... Mateo, CA (PRWEB) July 14, 2014 ... CONNECT patient registry platform, announced that three ... muscular dystrophies; the Phelan-McDermid Syndrome International Registry; ... Nephrotic Syndrome—have been awarded contracts by the ... of the creation of a new health ...
(Date:7/13/2014)... 30 years ago of soccer-ball-shaped carbon molecules called buckyballs ... there appears to be a new ball on the ... Tsinghua University in China have shown that a cluster ... similar to a carbon buckyball. It,s the first experimental ... of speculationdoes indeed exist. , "This is the first ...
(Date:7/13/2014)... July 13, 2014 2014 Deep Research ... a professional and in-depth study on the current state ... , The report provides a basic overview of the ... market analysis and Chinese domestic market analysis are provided ... landscape of the market. A comparison between the international ...
Breaking Biology Technology:Minerva Neurosciences Announces Appointment Of Frederick W. Ahlholm As VP Of Finance And Chief Accounting Officer 2PatientCrossroads Fuels Development of New National Clinical Research Network 2PatientCrossroads Fuels Development of New National Clinical Research Network 3Researchers discover boron 'buckyball' 2Researchers discover boron 'buckyball' 32014 Nano Silver Industry in Global and China Regions Development Proposals Analysis Available at DeepResearchReports.com 22014 Nano Silver Industry in Global and China Regions Development Proposals Analysis Available at DeepResearchReports.com 3
... 5 DURECT Corporation,(Nasdaq: DRRX ) announced today ... 31, 2007. Total revenues were $6.6 million for the,three ... for the same,period in 2006. Net loss for the ... to a net loss of $9.8 million for the ...
... ST. LOUIS, Feb. 5 Monsanto Company,s ... global commercial,business, and Carl Casale, executive vice ... in separate presentations at two,conferences later this ... an update on the company,s,business performance and ...
... BEIJING and CLAREMONT, Calif., Feb. 5 /Xinhua-PRNewswire-FirstCall/ ... Board: KWBT) reports,on a meeting between Kiwa ... and Dr.,Xiao-Dong Huang from the Department of ... the possibility of collaboration in research and,development ...
Cached Biology Technology:DURECT Corporation Announces Fourth Quarter and Year End 2007 Financial Results 2DURECT Corporation Announces Fourth Quarter and Year End 2007 Financial Results 3DURECT Corporation Announces Fourth Quarter and Year End 2007 Financial Results 4DURECT Corporation Announces Fourth Quarter and Year End 2007 Financial Results 5DURECT Corporation Announces Fourth Quarter and Year End 2007 Financial Results 6DURECT Corporation Announces Fourth Quarter and Year End 2007 Financial Results 7DURECT Corporation Announces Fourth Quarter and Year End 2007 Financial Results 8DURECT Corporation Announces Fourth Quarter and Year End 2007 Financial Results 9Kiwa Bio-Tech Products Group Discusses Cooperative Research With the University of Waterloo, Canada 2Kiwa Bio-Tech Products Group Discusses Cooperative Research With the University of Waterloo, Canada 3
... system uses a burst of high-pressure ... acid-coated gold or tungsten microparticles to ... or organelles without dependence or interaction ... includes helium pressure regulator, solenoid, spacer ...
... system, 220-240 V, is used for ... The system includes the BioLogic LP ... MV-6 injection valve, proportioning valve or ... and fittings kit, column and conductivity ...
Sf21 Insect Cells (Frozen) in Max-XP Medium...
... have been developed for affinity capture ... variety of ProteinChip chemical surfaces allow ... their unique biochemical properties. Each chip ... sample comparison, and the chips are ...
Biology Products: