Navigation Links
Broken cellular 'clock' linked to brain damage
Date:11/25/2013

rhythm," Musiek said. "They get the same amount of sleep, but it's spread over the whole day. Rhythms in the way genes are expressed are lost."

FitzGerald uses mice lacking Bmal1 to study whether clock cells have links to diabetes and heart disease. He has shown that clock genes influence blood pressure, blood sugar and lipid levels.

Several years ago, Musiek, who at the time was a neurology resident at the University of Pennsylvania, and FitzGeralddecided to investigate how knocking out Bmal1 affects the brain. Holtzman, who has published pioneering work on sleep and Alzheimer's disease, encouraged Musiek to continue and expand these studies when he came to Washington University as a postdoctoral fellow.

In the new study, Musiek found that as the mice aged, many of their brain cells became damaged and did not function normally. The patterns of damage were similar to those seen in Alzheimer's disease and other neurodegenerative disorders.

"Brain cell injury in these mice far exceeded that normally seen in aging mice," Musiek said. "Many of the injuries appear to be caused by free radicals, which are byproducts of metabolism. If free radicals come into contact with brain cells or other tissue, they can cause damaging chemical reactions."

This led Musiek to examine the production of key antioxidant enzymes, which usually neutralize and help clear free radicals from the brain, thereby limiting damage. He found levels of several antioxidant proteins peak in the middle of the day in healthy mice. However, this surge is absent in mice lacking Bmal1. Without the surge, free radicals may remain in the brain longer, contributing to the damage Musiek observed.

"We're trying to identify more specifics about how problems in clock genes contribute to neurodegeneration, both with and without influencing sleep," Musiek said. "That's a challenging distinction to make, but it needs to be made because clock genes appear to control
'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. A sea of broken promises
2. Could a diet high in fish and flax help prevent broken hips?
3. Putting the spring back in broken hearts
4. Salk scientists open new window into how cancers override cellular growth controls
5. Increased fructose consumption may deplete cellular energy in patients with obesity and diabetes
6. Cellular secrets of plant fatty acid production understood
7. Make or break for cellular tissues
8. A non-invasive intracellular thermometer with fluorescent proteins has been created
9. Groundbreaking discovery of the cellular origin of cervical cancer
10. BUSM study shows role of cellular protein in regulation of binge eating
11. Stealthy microscopy method visualizes E. coli sub-cellular structure in 3-D
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... all have in common? Unlike most eukaryotic multicellular ... diploid, these organisms are all polyploid, meaning they have ... have 3 and 4 sets of chromosomes, respectively, and ... in fact most plant species are polyploid. Polyploidy, or ... but only recently, with the development of molecular tools, ...
(Date:9/30/2014)... professor and Howard Hughes Medical Institute investigator, and ... recipients in the 2014 round of grants from ... BRAIN (Brain Research through Advancing Innovative Neurotechnologies) Initiative ... September 30, provides more than $3 million in ... , The BRAIN Initiative, launched last year, is ...
(Date:9/30/2014)... of Medicine reports positive results of a phase ... subset of lung cancer marked by rearrangement of the ... with advanced non-small cell lung cancer testing positive for ... with 3 complete responses and 33 partial responses. Median ... disease to resume its growth after being slowed by ...
Breaking Biology News(10 mins):Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 2Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 3Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 4Salk scientists receive $3 million for BRAIN Initiative grant 2NEJM: Crizotinib effective in Phase 1 trial against ROS1 lung cancer 2
... bites, and business struggle to stay primed, researchers in ... and business practice is needed if a company is ... Practice from Inderscience Publishers, the team explains how businesses ... Palmira Lpez-Fresno of "STIGA" in Barcelona is working ...
... An undergraduate student at Rensselaer Polytechnic Institute has learned ... help the medicine go down. In fact, with his ... Among the most important and complex molecules in the ... how cells communicate with one another. Graduating senior Jeffery ...
... discovery of the duck-billed, egg-laying, otter-footed, beaver-tailed, venomous platypus ... must be a hoax. Sketches of its appearance were ... that the oddness of the platypus, looks isn,t just ... avian, reptilian and mammalian lineages that may hold clues ...
Cached Biology News:Programmed death boosts business 2Undergrad has sweet success with invention of artificial Golgi 2Undergrad has sweet success with invention of artificial Golgi 3Platypus genome decoded 2Platypus genome decoded 3
(Date:9/30/2014)... German . ... have demonstrated a new kind of building block for ... chips could be based on three-dimensional arrangements of nanometer-scale ... of the semiconductor industry CMOS fabrication of silicon ... collaborators at the University of Notre Dame are exploring ...
(Date:9/30/2014)... , Sept. 30, 2014 Nematicide is ... nematodes. Nematodes are microscopic parasitic roundworms, found in ... inside other plants and animals. Nematicides have tended ... other properties promoting migration through the soil. A ... 1,000 plant-parasitic nematodes. With more than 10,000 species ...
(Date:9/30/2014)... , Sept. 30, 2014 CORD:USE Cord Blood ... announce that it has entered into an Equity and ... which has licensed a series of patented technologies for the ... possible clinical applications.  Tianhe is performing Phase I/II clinical ... Spain using Tianhe,s Stem Cell Educator ...
(Date:9/30/2014)... BioHealth Innovation, Inc. (BHI), a ... and increasing access to early-stage funding in ... Tania Fernandez , Ph.D., has joined the BHI ... a member of the management team for a new ... million in seed and early-stage equity investments to therapeutics, ...
Breaking Biology Technology:A new dimension for integrated circuits: 3-D nanomagnetic logic 2A new dimension for integrated circuits: 3-D nanomagnetic logic 3Nematicides Market by Types (Fumigants, Organophosphates, Carbamate and Bio-Nematicides), Applications (Agrochemicals, Industrial, and Others), and Geography (North America, Europe, Asia-Pacific & ROW) - Global Trends & Forecasts to 2019 2CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 2CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 3CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 4Seasoned Life Sciences Venture Capitalist Tania Fernandez Joins BHI to Help Manage New BioHealth Gap Fund 2
... April 13, 2011 Today Massachusetts Life Sciences Center ... officials,  Organogenesis, Inc. President & CEO Geoff MacKay and ... Dan Road.  Upon completion in 2013, the company expects ... cell manufacturing plant.   Organogenesis is in ...
... Biosciences, a global manufacturer of products designed to ... labor intensive, today announced an agreement with Bruker ... microbial identification from cultures using MALDI-TOF proteomic finger-printing, ... research, and veterinary laboratory customers. The compatible product ...
... published in the March 14 edition of the ... and testing of a new type solar cell using ... nanowires (described has "quantum coaxial cables") had previously been ... chemically more stable large bandgap inorganic materials, should also ...
Cached Biology Technology:Organogenesis, Life Sciences Center Break Ground on World's Largest Automated Living Cell Manufacturing Plant 2Organogenesis, Life Sciences Center Break Ground on World's Largest Automated Living Cell Manufacturing Plant 3Organogenesis, Life Sciences Center Break Ground on World's Largest Automated Living Cell Manufacturing Plant 4Magellan Biosciences Announces Agreement with Bruker to Provide Microbiology Tools to Battle Drug Resistance 2Magellan Biosciences Announces Agreement with Bruker to Provide Microbiology Tools to Battle Drug Resistance 3Magellan Biosciences Announces Agreement with Bruker to Provide Microbiology Tools to Battle Drug Resistance 4Device proves solar cell potential of high bandgap inorganic nanowire arrays 2Device proves solar cell potential of high bandgap inorganic nanowire arrays 3
... N,N- bis- (3-D-Gluconamidopropyl)deoxycholamide White ... CHAPS and CHAPSO. Has reduced electrostatic interactions ... chromatography on DEAE-cellulose. Aggregation number: 8-16. ... H 2 O. Aggregation number 8 - ...
... 2000 Pipette is a synonym for pipetting ... robust design, and superior operating comfort. Its ... the measuring stroke and blow-out as well ... system ensures utmost accuracy and precision. Ejection ...
... This protein is a member of the ... Members of the PAX family typically contain ... homeodomain. These proteins play critical roles during ... 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand ...
Compact, portable device, seals 96 and 384 well plates with preset temperature optimised for Eppendorf heat sealing foils and films. Suitable for plates of different heights. AC input: 50/60 Hz230 V...
Biology Products: