A clinical trial involving nearly 300 Chinese men and women residing in one of China's most polluted regions found that daily consumption of a half cup of broccoli sprout beverage produced rapid, significant and sustained higher levels of excretion of benzene, a known human carcinogen, and acrolein, a lung irritant. Researchers from the Johns Hopkins Bloomberg School of Public Health, working with colleagues at several U.S. and Chinese institutions, used the broccoli sprout beverage to provide sulforaphane, a plant compound already demonstrated to have cancer preventive properties in animal studies. The study was published in the June 9 online edition of the journal Cancer Prevention Research.
"Air pollution is a complex and pervasive public health problem," notes John Groopman, PhD, Anna M. Baetjer Professor of Environmental Health at the Johns Hopkins Bloomberg School of Public Health and one of the study's co-authors. "To address this problem comprehensively, in addition to the engineering solutions to reduce regional pollution emissions, we need to translate our basic science into strategies to protect individuals from these exposures. This study supports the development of food-based strategies as part of this overall prevention effort."
Air pollution, an increasing global problem, causes as many as seven million deaths a year worldwide, according to the World Health Organization, and has in recent years reached perilous levels in many parts of China. Last year, the International Agency for Research on Cancer classified air pollution and particulate matter (PM) from air pollution as carcinogenic to humans. Diets rich in cruciferous vegetables, of which broccoli is one, have been found to reduce risk of chronic degenerative diseases, including cancer. Broccoli sprouts are a source of glucoraphanin, a compound that generates sulforaphane when the plant is chewed or the beverage swallowed. It acts to increase enzymes that enhance t
|Contact: Susan Sperry|
Johns Hopkins University Bloomberg School of Public Health