Navigation Links
Broccoli component limits breast cancer stem cells, U-M study finds
Date:5/3/2010

This release is available in Spanish.

ANN ARBOR, Mich. A compound derived from broccoli could help prevent or treat breast cancer by targeting cancer stem cells -- the small number of cells that fuel a tumor's growth -- according to a new study from researchers at the University of Michigan Comprehensive Cancer Center.

The study tested sulforaphane, a component of broccoli and broccoli sprouts, in both mice and cell cultures. Researchers found sulforaphane targeted and killed the cancer stem cells and prevented new tumors from growing.

"Sulforaphane has been studied previously for its effects on cancer, but this study shows that its benefit is in inhibiting the breast cancer stem cells. This new insight suggests the potential of sulforaphane or broccoli extract to prevent or treat cancer by targeting the critical cancer stem cells," says study author Duxin Sun, Ph.D., associate professor of pharmaceutical sciences at the U-M College of Pharmacy and a researcher with the U-M Comprehensive Cancer Center.

Results of the study appear in the May 1 issue of Clinical Cancer Research.

Current chemotherapies do not work against cancer stem cells, which is why cancer recurs and spreads. Researchers believe that eliminating the cancer stem cells is key to controlling cancer.

In the current study, researchers took mice with breast cancer and injected varying concentrations of sulforaphane from the broccoli extract. Researchers then used several established methods to assess the number of cancer stem cells in the tumors. These measures showed a marked decrease in the cancer stem cell population after treatment with sulforaphane, with little effect on the normal cells. Further, cancer cells from mice treated with sulforaphane were unable to generate new tumors. The researchers then tested sulforaphane on human breast cancer cell cultures in the lab, finding similar decreases in the cancer stem cells.

"This research suggests a potential new treatment that could be combined with other compounds to target breast cancer stem cells. Developing treatments that effectively target the cancer stem cell population is essential for improving outcomes," says study author Max S. Wicha, M.D., Distinguished Professor of Oncology and director of the U-M Comprehensive Cancer Center.

The concentrations of sulforaphane used in the study were higher than what can be achieved by eating broccoli or broccoli sprouts. Prior research suggests the concentrations needed to impact cancer can be absorbed by the body from the broccoli extract, but side effects are not known. While the extract is available in capsule form as a supplement, concentrations are unregulated and will vary.

This work has not been tested in patients, and patients are not encouraged to add sulforaphane supplements to their diet at this time.

Researchers are currently developing a method to extract and preserve sulforaphane and will be developing a clinical trial to test sulforaphane as a prevention and treatment for breast cancer. No clinical trial is currently available.


'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Related biology news :

1. Broccoli sprouts may prevent stomach cancer by defeating Helicobacter pylori
2. Gutsy germs succumb to baby broccoli
3. Extract of broccoli sprouts may protect against bladder cancer
4. Natural compound in broccoli could treat devastating genetic skin disorder
5. Natural chemical found in broccoli helps combat skin blistering disease
6. Natural S-Equol suggested as critical component in SE5-OH for reducing menopausal hot flushes
7. NASA technology key component of new diagnostic aid from DynaDx
8. Green tea component may help preserve stored platelets, tissues
9. Purple sweet potato means increased amount of anti-cancer components
10. InVitria to Unveil Powerful Cell Culture Media Component ZAP-CHO
11. DNA component can stimulate and suppress the immune response
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... PUNE, India , March 28, 2017 ... (Analog, IP, Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), ... Maintenance), Vertical, and Region - Global Forecast to 2022", ... 30.37 Billion in 2016 and is projected to reach ... 15.4% between 2017 and 2022. The base year considered ...
(Date:3/24/2017)... -- The Controller General of Immigration from Maldives Mr. ... have received the prestigious international IAIR Award for the most innovative high ... ... Maldives Immigration Controller ... (small picture on the right) have received the IAIR award for the ...
(Date:3/23/2017)... 2017 The report "Gesture Recognition and Touchless Sensing Market ... - Global Forecast to 2022", published by MarketsandMarkets, the market is expected to ... between 2017 and 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:9/25/2017)... ... September 25, 2017 , ... Bluebird, Inc. , innovator ... they have been successfully integrated with a national database provided by the Registraduría ... the region. , Bluebird biometric lineup that have been approved to operate ...
(Date:9/22/2017)... Scottsdale, AZ (PRWEB) , ... September 22, 2017 ... ... announced that it recently raised nearly $200,000 via Kickstarter. The proceeds will be ... 623 backers pre-ordered the B2v2, exceeding the original Kickstarter goal by nearly 1,000%. ...
(Date:9/21/2017)... Baltimore, MD (PRWEB) , ... September 21, 2017 ... ... moving its HQ office, which includes executive, engineering and manufacturing functions to The ... affiliated operation The Factory™, provide a full range of manufacturing and business services ...
(Date:9/21/2017)... ... September 21, 2017 , ... Today, ... professionals, has announced the addition of 5 new courses to its prospectus. These ... with Regulation 21 CFR Part 11 on Electronic Records and Electronic Signatures (Part ...
Breaking Biology Technology: