Navigation Links
Broccoli component limits breast cancer stem cells, U-M study finds
Date:5/3/2010

This release is available in Spanish.

ANN ARBOR, Mich. A compound derived from broccoli could help prevent or treat breast cancer by targeting cancer stem cells -- the small number of cells that fuel a tumor's growth -- according to a new study from researchers at the University of Michigan Comprehensive Cancer Center.

The study tested sulforaphane, a component of broccoli and broccoli sprouts, in both mice and cell cultures. Researchers found sulforaphane targeted and killed the cancer stem cells and prevented new tumors from growing.

"Sulforaphane has been studied previously for its effects on cancer, but this study shows that its benefit is in inhibiting the breast cancer stem cells. This new insight suggests the potential of sulforaphane or broccoli extract to prevent or treat cancer by targeting the critical cancer stem cells," says study author Duxin Sun, Ph.D., associate professor of pharmaceutical sciences at the U-M College of Pharmacy and a researcher with the U-M Comprehensive Cancer Center.

Results of the study appear in the May 1 issue of Clinical Cancer Research.

Current chemotherapies do not work against cancer stem cells, which is why cancer recurs and spreads. Researchers believe that eliminating the cancer stem cells is key to controlling cancer.

In the current study, researchers took mice with breast cancer and injected varying concentrations of sulforaphane from the broccoli extract. Researchers then used several established methods to assess the number of cancer stem cells in the tumors. These measures showed a marked decrease in the cancer stem cell population after treatment with sulforaphane, with little effect on the normal cells. Further, cancer cells from mice treated with sulforaphane were unable to generate new tumors. The researchers then tested sulforaphane on human breast
'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2

Related biology news :

1. Broccoli sprouts may prevent stomach cancer by defeating Helicobacter pylori
2. Gutsy germs succumb to baby broccoli
3. Extract of broccoli sprouts may protect against bladder cancer
4. Natural compound in broccoli could treat devastating genetic skin disorder
5. Natural chemical found in broccoli helps combat skin blistering disease
6. Natural S-Equol suggested as critical component in SE5-OH for reducing menopausal hot flushes
7. NASA technology key component of new diagnostic aid from DynaDx
8. Green tea component may help preserve stored platelets, tissues
9. Purple sweet potato means increased amount of anti-cancer components
10. InVitria to Unveil Powerful Cell Culture Media Component ZAP-CHO
11. DNA component can stimulate and suppress the immune response
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... MOUNTAIN VIEW, Calif. , Nov. 20, 2014 /PRNewswire/ ... for higher driver efficiency are piloting the North American ... the number of accidents growing, gesture recognition systems that ... will make a mark in the industry. ... of the Automotive Gesture Recognition Market in ...
(Date:11/18/2014)... Md. , Nov. 17, 2014 The Parenteral ... and U.S. regulatory agencies will speak and at least seven ... Metrics Conference at the Omni Shoreham Hotel in ... pleased once again to have significant support from the regulatory ... Europe in our effort to help ...
(Date:11/10/2014)... U.S. store shelves in early 2010, and people have ... packets can be tossed into a washing machine without ... The convenience, though, has come with risks for young ... Children,s Hospital found that from 2012 through 2013, U.S. ... than 6 years of age swallowing, inhaling, or otherwise ...
Breaking Biology News(10 mins):Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2Study finds laundry detergent pods, serious poisoning risk for children 2
... and athletes choose to wear the color red when they ... Science , a journal of the Association for Psychological Science, ... levels. The new study, conducted by psychological scientist Daniel ... males who chose red as their color in a competitive ...
... at sites outside the bone marrow in the ... in Munich now show that a specific type of ... cells. Balanced hematopoiesis is essential for the function ... place mainly in the liver and the spleen. Later ...
... the gym. But doctors use the human pulse as a ... professor of chemical engineering at Stanford, has developed a heart ... a postage stamp. The flexible skin-like monitor, worn under an ... doctors detect stiff arteries and cardiovascular problems. The devices ...
Cached Biology News:High-testosterone competitors more likely to choose red 2Herpes infections: Natural killer cells activate hematopoiesis 2Stanford engineers monitor heart health using paper-thin flexible 'skin' 2Stanford engineers monitor heart health using paper-thin flexible 'skin' 3
(Date:11/21/2014)... , Nov. 20, 2014 /CNW/ - Aequus ... to announce that it has closed a brokered ... warrants for approximately C$3.7 million.  Cormark Securities Inc. ... in the Brokered Offering for a syndicate of ... PI Financial Corp. (collectively the "Agents"). Concurrently with ...
(Date:11/18/2014)... Calif. , Nov. 18, 2014 Cord ... platinum sponsor of the 10th Annual World Stem Cell Summit, ... medicine stakeholders. The 2014 World Stem Cell Summit will be ... San Antonio, Texas . The ... and development of lifesaving cures and therapies, convening the most ...
(Date:11/18/2014)... pH measurement and control is vital in a ... food and beverage industries. But what exactly is pH, ... sensors work? METTLER TOLEDO has produced a guide to ... these questions and more. , METTLER TOLEDO provides a ... The actual sensor, the pH electrode, is therefore the ...
(Date:11/18/2014)... 18, 2014 American Process Inc. ... formed a partnership with researchers at Georgia Institute ... Technology, and the USDA’s Forest Products Laboratory to ... nanocellulose. Nanocellulose is a rapidly emerging high performance ... project is to replace heavy steel structures within ...
Breaking Biology Technology:Aequus Pharmaceuticals closes $4.2 million private placement financing 2Aequus Pharmaceuticals closes $4.2 million private placement financing 3Cord Blood Registry Sponsors 2014 World Stem Cell Summit 2Cord Blood Registry Sponsors 2014 World Stem Cell Summit 3pH Guide from METTLER TOLEDO Explains Measurement, Theory and Practice of pH Applications 2American Process Inc. Announces Partnership to Develop Ultra-Strong, Lightweight Automotive Components Using Nanotechnology from Nature 2American Process Inc. Announces Partnership to Develop Ultra-Strong, Lightweight Automotive Components Using Nanotechnology from Nature 3
... ... launching of PrescriberPRO@Home. This Database will allow marketers to send targeted offers to Physicians, ... , ... 23, 2010 -- Healthcare Data Solutions (HDS) has recently expanded its healthcare ...
... Inc. (Nasdaq: ITMN ) announced today that it will release first ... 4:00 p.m. Eastern time .  A live conference call and webcast ... that same day. , , ... access the live teleconference, dial 888-799-0528 (U.S.) or 973-200-3372 (international), conference ID# ...
... ... to Qualify for Free Oragene®•DNA Collection Kits for Classroom Use , ... Ottawa, ON (PRWEB) April 22, 2010 ... stabilization and preparation, today announced it is marking DNA Day 2010 by introducing a ...
Cached Biology Technology:Healthcare Data Solutions Announces Latest Database, PrescriberPRO@Home. 2Healthcare Data Solutions Announces Latest Database, PrescriberPRO@Home. 3InterMune to Release First Quarter Financial Results on April 29 2DNA Genotek Marks DNA Day 2010 with a Focus on Supporting Science Education 2DNA Genotek Marks DNA Day 2010 with a Focus on Supporting Science Education 3
... phase reagent for Virus ... & unique water insoluble ... detergents and chaotropes; Engineered ... non-envelop viruses while preserving ...
Golgi Sampler Kit 10g each...
Caveolin Sampler Kit 10g each...
Monoclonal Antibody toSynapsin I a and I b Neurofilament associated protein from mouse brain extracts (4)....
Biology Products: