Navigation Links
Broad Institute researchers introduce next generation tool for visualizing genomic data
Date:8/4/2008

Researchers are collecting vast amounts of diverse genomic data with ever-increasing speed, but effective ways to visualize these data in an integrated manner have lagged behind the ability to generate them. To address this growing need, researchers at the Broad Institute have developed the Integrative Genomics Viewer (IGV), a novel and freely available visualization tool that helps users simultaneously integrate and analyze different types of genomic data, and gives them the flexibility to zoom in on a specific genomic region of interest or to pan out for a broad, whole genome view.

"This new tool offers a Google Maps-like view of integrative genomic data," said Jill Mesirov, Chief Informatics Officer and Director of Computational Biology and Bioinformatics at the Broad Institute. "It brings together different kinds of genomic data into a single, holistic view. I'm incredibly proud of our computational scientists for responding so rapidly and effectively to the critical needs of the growing genomics research community."

With IGV, researchers can still choose a Google Maps-like "street view" of the As, Cs, Ts, and Gs that make up the genome, but they can also simultaneously visualize additional layers of complex information about gene expression as well as sequence alterations, or mutations, in the genetic code. Other genomic details, such as copy number variation, chromatin immunoprecipation data, and epigenetic modifications, can also be viewed in IGV. Moreover, all these data types can be overlaid or superimposed to determine how changes at one level will affect another. Users can choose from a variety of display options, viewing their data as a heat map, histogram, scatter plot, or other formats of their choice. This new visualization tool is free and publicly available to researchers via the web.

"Other tools offer detailed, localized views of genomic data, and a few tools are equipped to provide a whole genome view," said Senior Software Engineer Jim Robinson, one of the program's creators. "IGV was designed to integrate both and to provide smooth zooming and panning across all resolution scales. "

"Most visualization tools are limited in their ability to handle multiple types of genomic data and are typically 'retrofitted' to accommodate new data types as they have arisen," said Michael Reich, Director of Cancer Informatics Development at the Broad Institute. "IGV was designed from the ground up to integrate all of these data, and to provide a strong platform for future growth and refinement."

Broad Associate Member John Rinn, an assistant professor at Harvard University and Beth Israel Deaconess Medical Center, has used a variety of visualization tools to sift through different types of genomic data. "Before I was introduced to IGV, I had to use three different programs to visually integrate my data," Rinn said. "But now this one, universal browser allows me to rapidly scan the entire genome and identify promising regions, which has revolutionized my work."

IGV promises to increase the flow of discovery in many areas of biomedical research. "This tool is designed to enable researchers to view many types of genomic data, especially those relevant to human disease," said Reich. "We're particularly excited about its already groundbreaking use in ongoing studies of the cancer genome."


'/>"/>

Contact: Nicole Davis
ndavis@broad.mit.edu
617-258-0952
Broad Institute of MIT and Harvard
Source:Eurekalert

Related biology news :

1. Darwin Symposium at Field Museum offers broad overview of his science and its impact
2. Scripps Research discovery leads to broad potential applications in CovX-Pfizer deal
3. Vobile Launches VideoDNA Live; Enables Real-Time Digital Content Protection for Live Broadcast Events
4. NOAA takes first broad look at soot from ships
5. Palm Beach County wants to establish a Max Planck Institute in Florida
6. Midlands Consortium delighted to be chosen to host £1 billion energy institute
7. $22 million gift from Alfred Taubman launches new biomedical research institute
8. 3 Columbia University Medical Center faculty elected to Institute of Medicine
9. Stowers Institutes Xie Lab demonstrates dual intrinsic and extrinsic control of stem cell aging
10. Weizmann Institute scientists discover: A risk distribution law for evolution
11. Ludwig Institute for Cancer Research to set up its first Asian branch in Singapore
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... Feb. 2, 2016   Parabon NanoLabs ... U.S. Army Research Office and the Defense Forensics ... sensitivity of the company,s Snapshot Kinship Inference ... and, more generally, defense-related DNA forensics.  Although Snapshot ... (predicting appearance and ancestry from DNA evidence), it ...
(Date:2/1/2016)... 2016  Today, the first day of American Heart ... develop a first of its kind workplace health solution ... In the first application of Watson ... ), and Welltok will create a new offering that ... analytics, delivered on Welltok,s health optimization platform. The effort ...
(Date:1/27/2016)... CHESTER, Ohio , Jan. 27, 2016  Rite ... supplier based in West Chester, Ohio ... their award winning service staff, based in ... technical capacity and ability to provide modifications, installations and ... John Dovalina , CEO of PLUS, commented, "PLUS has ...
Breaking Biology News(10 mins):
(Date:2/10/2016)...  Matchbook, Inc., a company specializing in procurement ... announced today the appointment of Jim Shuman ... nearly 25 years of experience in supply chain, ... two decades in executive level roles as the ... and, most recently headed global logistics and procurement ...
(Date:2/10/2016)... San Mateo, CA (PRWEB) , ... February 10, ... ... Registry of Multiplex Testing (PROMPT), a research registry built on the secure online ... in September 2014. More than 1,600 participants have joined the PROMPT study, which ...
(Date:2/9/2016)... Philadelphia, PA (PRWEB) , ... February 09, 2016 , ... ... balance, the 2016 Wharton Health Care Business Conference will bring together over 500 top ... ahead for an industry in transformation. The conference, organized by MBA students of the ...
(Date:2/9/2016)... ... February 09, 2016 , ... Tunnell Consulting, Inc. announced that Frédéric ... he will focus on acquiring new accounts and work closely with existing Tunnell clients ... “Fred brings to our European clients more than 15 years of experience in the ...
Breaking Biology Technology: