Navigation Links
Broad Institute awarded major grant to bolster epigenomics research
Date:9/30/2008

ctions. The answer lies mainly in the epigenome, a special code of chemical tags affixed to DNA or to its supporting proteins (known as "histones") that act as gatekeepers to the genome enabling genes to be switched on or ensuring they remain switched off. In the past few years, two techniques have transformed researchers' abilities to probe cells' epigenomes: ChIP-Seq and high-throughput bisulfite sequencing (HTBS). These technologies can help pinpoint the genomic locations of various types of chemical tags, such as methyl groups, and thus chart the epigenome.

The Reference Epigenome Mapping Center (REMC) at the Broad Institute will help create comprehensive, genome-scale maps of the epigenomes of a variety of cells, including human embryonic stem cells, various adult stem cells, and other key cell types. The researchers will survey both the DNA backbone and its accompanying histone proteins for chemical modifications using HTBS and ChIP-Seq respectively, which take advantage of the increased throughput and decreased cost of next-generation DNA sequencing, and provide unprecedented precision and genomic coverage.

Just as the Human Genome Project provided researchers with a draft genome sequence, the REMCs will help create draft epigenomic maps of a diverse set of cell types. Those data will serve as a vast resource for the scientific community to enhance the understanding of epigenetic mechanisms of disease, pinpoint novel molecular targets for therapy, complement ongoing investigations of the genetic susceptibilities of a wide range of diseases, and bolster current research in stem cell biology and regenerative medicine.

The NIH award to the Broad Institute represents one of four areas of epigenomic research to receive funding under the NIH Roadmap Epigenomics Program. In addition to the work of the epigenome mapping centers, other funded centers will focus on epigenomics data analysis and coordination, technology development in epige
'/>"/>

Contact: Nicole Davis
ndavis@broad.mit.edu
Broad Institute of MIT and Harvard
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Pittsburgh researchers identify source of multipotent stem cells with broad regenerative potential
2. Aberrations in region of chromosome 1q21.1 associated with broad range of disorders in children
3. Eli and Edythe L. Broad make unprecedented gift to endow Broad Institute of Harvard & MIT
4. Broad Institute awarded grant to develop chemical probes for human biology and disease
5. Carnegie Mellon urges industry to broaden carbon footprint calculations
6. Broad Institute researchers introduce next generation tool for visualizing genomic data
7. NOAA takes first broad look at soot from ships
8. Vobile Launches VideoDNA Live; Enables Real-Time Digital Content Protection for Live Broadcast Events
9. Scripps Research discovery leads to broad potential applications in CovX-Pfizer deal
10. Darwin Symposium at Field Museum offers broad overview of his science and its impact
11. Swiss Institute of Bioinformatics celebrates 10th birthday by presenting major gifts to human health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... mastodons, short-faced bears, giant ground sloths, saber-toothed cats ... 13,000 years ago at the end of the Pleistocene ... been debated by scientists who, until recently, could only ... including UC Santa Barbara,s James Kennett, professor emeritus in ... collision with Earth played a major role in the ...
(Date:8/27/2014)... of fish began exploring land and evolved into tetrapods ... ancient fish used their fishy bodies and fins in a ... scientific mysteries. , Researchers at McGill University published in ... called Polypterus , to help show what might have ... water. Polypterus is an African fish that can ...
(Date:8/27/2014)... invasive grass species frequently found in forests has created ... on American toads, a new University of Georgia study ... to the U.S. in the early 1900s, is one ... to more than a dozen states in the past ... and in forests, it can survive in widely diverse ...
Breaking Biology News(10 mins):Nanodiamonds are forever 2Nanodiamonds are forever 3Walking fish reveal how our ancestors evolved onto land 2More wolf spiders feasting on American toads due to invasive grass, UGA study shows 2More wolf spiders feasting on American toads due to invasive grass, UGA study shows 3
... most important model organisms for molecular science today and is ... The genes of higher-level plants and animals, even humans, are ... As such, the accuracy and completeness of E.coli genome information ... , In an attempt to consolidate the efforts of scientists ...
... have identified a key component of the mechanism spermatozoa ... steady swimming undulation to the whip-cracking snap that thrusts ... research pathway that the researchers said could help scientists ... new contraceptives to thwart sperm entry into the egg. ...
... mammals may have something in common, researchers report in the ... so-called hedgehog (Hh) signaling pathway--an ancient suite of genes involved ... an important role in fat formation in both flies and ... effect of genes on fat storage from insects to mammals, ...
Cached Biology News:MBL leads effort to update E. coli genome 2How sperm crack the whip 2How sperm crack the whip 3Insects and mammals share common fat-building pathway, study suggests 2
(Date:8/27/2014)... 27, 2014 Rhythm, a biopharmaceutical company developing ... that result in metabolic disorders, announced today that it ... the U.S. Securities and Exchange Commission (SEC) relating to ... common stock. The number of shares to be offered ... yet been determined. Citigroup and Cowen and ...
(Date:8/27/2014)...   MSC , a healthcare performance improvement company ... appointment of Mary Beth Loesch to President ... experience preparing companies for rapid growth and market expansion, ... of Corporate Development and Healthcare. In that role, she ... well as corporate strategy and marketing. Previously, Loesch served ...
(Date:8/27/2014)... , Aug. 27, 2014 Reportlinker.com announces ... in its catalogue: Global Chelating Agents ... About Chelating Agent A chelating agent ... bonds with metal ions, thereby forming a metal-ion ... metal-ions have on chemical processes, formulations, and the ...
(Date:8/27/2014)... MADISON, N.J. , Aug. 27, 2014 /PRNewswire/ ... significant potential to help physicians better identify early-stage ... progression and disability, according to a new study ... from Quest Diagnostics (NYSE: DGX ) ... of the 14-3-3eta protein outperformed conventional antibody-serum testing, ...
Breaking Biology Technology:Rhythm Files Registration Statement for Proposed Initial Public Offering 2MSC names Mary Beth Loesch President and CEO 2Global Chelating Agents Market 2014-2018 2Global Chelating Agents Market 2014-2018 3Global Chelating Agents Market 2014-2018 4Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 3Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 4
... a chip an important step toward the optical ... carry information between chips within today,s computers. University of ... ultra compact, low power pulse compressor on a silicon ... appeared online in the journal Nature Communications ...
... a major breakthrough that could help shape the future of ... structures can be built on a surface. The discovery ... new nano devices such as cutting-edge optical and electronic technologies ... the prestigious journal Nature Chemistry , the team of ...
... in the search for the next generation of ... Lawrence Berkeley National Laboratory (Berkeley Lab) and the ... ultra-thin layers of the semiconductor indium arsenide onto ... with excellent electronic properties. A member of the ...
Cached Biology Technology:Short, on-chip light pulses will enable ultrafast data transfer within computers 2Short, on-chip light pulses will enable ultrafast data transfer within computers 3Short, on-chip light pulses will enable ultrafast data transfer within computers 4World-first to provide building blocks for new nano devices 2Ultrathin alternative to silicon for future electronics 2Ultrathin alternative to silicon for future electronics 3
Protein 3D structure prediction, via threading. Easy to use....
L1 Protein of Human Papilloma Virus Purified Anti-Viral-transformed cells clone CAMVIR-1, Isotype Mouse IgG 2a , 0.1 mg Consult technical datasheet for details....
ANTI 5-HYDROXYTRYPTOPHAN CONJ....
PAb to Hu-IFN-Alpha/Beta R2 [(IFNAR2) CD118], Rabbit Serum, neutralizing Binds to but does not neutralize human interferon alpha/beta receptor...
Biology Products: