Navigation Links
Brittle-bone babies helped by fetal stem cell grafts
Date:12/16/2013

Osteogeneis imperfecta (OI) is a congenital bone disease that causes stunted growth and repeated, painful fracturing. Ultrasound scans can reveal fractures already in the fetus, and now an international team of researchers from Sweden, Singapore and Taiwan have treated two babies in utero by injecting bone-forming stem cells. The longitudinal results of the treatment are published in the journal Stem Cells Translational Medicine.

The babies were treated with mesenchymal stem cells, connective tissue cells that can form and improve bone tissue. The stem cells were extracted from the livers of donors and although they were completely unmatched genetically, there was no rejection and the transplanted cells were accepted as self.

Back in 2005, a paper was published from Karolinska Institutet in Sweden describing how stem cells were given to a female fetus. The present study describes how the girl suffered a large number of fractures and developed scoliosis up to the age of eight, whereupon the researchers decided to give her a fresh stem cell graft from the same donor. For the next two years the girl suffered no new fractures and improved her growth rate. Today she takes dance lessons and participates more in PE at school.

Another unborn baby with OI, a girl from Taiwan, was also given stem cell transplantation by the Karolinska Institutet team and their colleagues from Singapore. The girl subsequently followed a normal and fracture-free growth trajectory until the age of one, when it levelled off. She was given a fresh stem cell treatment and her growth resumed. The girl started to walk and has since not suffered any new fractures. Today she is four years old.

"We believe that the stem cells have helped to relieve the disease since none of the children broke bones for a period following the grafts, and both increased their growth rate," says study leader Dr Cecilia Gtherstrm, researcher at Karolinska Institutet's Departm
'/>"/>

Contact: Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet
Source:Eurekalert

Page: 1 2

Related biology news :

1. UT study: Chemical in antibacterial soaps may harm nursing babies
2. Rare pregnancy condition programs babies to become overweight in later life
3. Bigger birth weight babies at greater risk of autism
4. The right amount of vitamin D for babies
5. Pregnant women with high celiac disease antibodies are at risk for low birth weight babies
6. Friend or foe: Babies choose sides early
7. Caffeine linked to low birth weight babies
8. Gene linked to respiratory distress in babies
9. Better blood transfusions for preterm babies
10. Microscopic packets of stem cell factors could be key to preventing lung disease in babies
11. Trial of HIV test for babies in Africa could make a big difference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/7/2015)... 2015 Research and ... of the "Capacitive Fingerprint Sensors Patent Landscape" ... this date, fingerprint sensing technology is the most ... are well developed. This patent landscape focuses on ... The domain of capacitive fingerprint sensors is closely ...
(Date:7/2/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/jvft55/next_generation ) ... Biometrics Market by Application, Technology, Function & Geography - ... The next generation biometrics market is expected ... of 17.9% between 2015 and 2020 Travel ... Safran SA ( France ), ...
(Date:6/29/2015)... 24, 2015 Research and ... "Latin America Biomedical Sensors Market - Growth, Trends ... The Latin America Biomedical Sensors market is estimated ... 2.04% over the period 2014-2020 The near ... the genetic formulation of each individual. These sensors can ...
Breaking Biology News(10 mins):Worldwide Capacitive Fingerprint Sensors Patent Landscape Market Report 2015-2020 - Main IP Holders include Seiko Epson, AuthenTec, Sony and STMicroelectronics 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 3Latin America Biomedical Sensors Market Report 2015-2020 2
... (Feb. 6, 2014) Declines in the underlying brain skills ... In fact, this cognitive decline is a fact of life ... the cognitive health of older adults are critically important for ... activity and cognitive training are among the efforts aimed at ...
... at Rice University and the University of Texas Medical ... sensitive and efficient test for the diarrheal disease cryptosporidiosis ... Results from the diagnostic developed by the lab of ... strip that resembles a pregnancy test. Lines on the ...
... have for the first time sequenced an ancient RNA genome ... old - pushing its origin back at least 2,000 years and ... to its spread., Researchers at the University of Warwick have detected ... in a 750-year-old barley grain found at a site near the ...
Cached Biology News:Nutritional supplement improves cognitive performance in older adults, study finds 2Nutritional supplement improves cognitive performance in older adults, study finds 3Quick test finds signs of diarrheal disease 2Quick test finds signs of diarrheal disease 3RNA sequencing of 750-year-old barley virus sheds new light on the Crusades 2RNA sequencing of 750-year-old barley virus sheds new light on the Crusades 3
(Date:7/29/2015)... -- US-Australian drug discovery company, Novogen Limited (ASX: NRT; ... to progressing its ground-breaking technology platforms to Phase 1 ... the Company delivers the best value for shareholders. ... said the Company currently had an extensive program of ... and academic partnerships and initiatives, and he was working ...
(Date:7/29/2015)... ... July 29, 2015 , ... G-CON Manufacturing, Inc., the leading ... 2nd generation cell therapy POD® design. The 2nd generation portfolio not only delivers ... new POD® design. , “G-CON first offered our miniPOD CT product line ...
(Date:7/29/2015)...  Pfenex Inc. (NYSE MKT: PFNX) announced today that ... on Thursday, August 13, 2015, before the open of ... host a conference call to discuss the financial results ... the financial results and business update will be publicly ... 1-866-376-8058 (US) or 1-412-542-4131 (international) and reference Pfenex to ...
(Date:7/29/2015)... ... 2015 , ... Finding gooey or crusty material in the corner of your ... considerable number of terms in popular use to describe it, ophthalmologists call it “gound” ... mucus, blood cells, skin cells and dust, but until now there has been virtually ...
Breaking Biology Technology:Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 3Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 4Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 5Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 6Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 7Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 8Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 9Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 10G-CON Manufacturing Launches Their 2nd Generation Cell Therapy Cleanroom POD® 2G-CON Manufacturing Launches Their 2nd Generation Cell Therapy Cleanroom POD® 3Pfenex To Report Second Quarter 2015 Results and Provide Business Update on Thursday, August 13, 2015 2What Are ‘Eye Crusties’ Made Of? uBiome Invites Citizen Scientists to Find Out 2What Are ‘Eye Crusties’ Made Of? uBiome Invites Citizen Scientists to Find Out 3What Are ‘Eye Crusties’ Made Of? uBiome Invites Citizen Scientists to Find Out 4
... May 22 SuperGen, Inc.,(Nasdaq: SUPG ... discovery, rapid,development and commercialization of therapies for ... Michael Molkentin, C.P.A.,Chief Financial Officer and Corporate ... President of Drug Discovery Operations, are scheduled,to ...
... PHILLIPSBURG, N.J., May 22 Celldex,Therapeutics (a wholly-owned ... that its lead product,candidate, CDX-110, being developed for ... subject of an oral presentation at the 44th,Annual ... (ASCO). The,ASCO meeting will be held at McCormick ...
... AMSTERDAM, The Netherlands, May 22 Amsterdam,Molecular ... field of human gene,therapy, today announced that ... in Rome, Italy, to their advanced small ... of Duchenne,muscular dystrophy (DMD). The combination with ...
Cached Biology Technology:SuperGen to Present at FBR Capital Markets 12th Annual Spring Investor Conference on May 29, 2008 2AVANT Immunotherapeutics Announces Oral Presentation of CDX-110 at ASCO Annual Meeting 2AVANT Immunotherapeutics Announces Oral Presentation of CDX-110 at ASCO Annual Meeting 3AMT Accesses Technology for Treatment of Duchenne Muscular Dystrophy 2AMT Accesses Technology for Treatment of Duchenne Muscular Dystrophy 3
Special grade: for molecular biology Density: 1.000 g/mL (20 C)...
Mol wt: average mol wt12,360.96 Da by calculation...
... Grace's medium were developed in several laboratories ... of these modifications were developed by Dr. ... derived from the cabbage looper,Tricoplusia ni. This ... The medium when properly supplemented has been ...
... clear polystyrene with frosted labeling surfaces, ... cell counting. 100% integrity tested. Linkage: ... product number, created to easily match ... availability yet, please order under the ...
Biology Products: