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Bright lights: Mystery of glowing antibody solved by Scripps research scientists
Date:2/28/2008

body.

This light-generating mechanism has rarely been observed in other luminescent proteins found in nature, Debler said. The neat thing about this system is that it acts like a molecular light switch. Neither stilbene nor the antibody themselves are notably fluorescent, but, when these two molecules combine, they yield an incredibly intense blue light.

It is the special photophysical behaviorthe extreme brightness coupled with the switch-like characterthat makes the EP2-19G2 antibody attractive as a potential biosensor and as a model for the development of other equally potent types of luminescent antibody-chromophore complexes.


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Contact: Mika Benedyk
mbenedyk@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

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