Navigation Links
Brief exposure to performance-enhancing drugs may be permanently 'remembered' by muscles
Date:10/27/2013

Brief exposure to anabolic steroids may have long lasting, possibly permanent, performance-enhancing effects, shows a study published today [28 October] in The Journal of Physiology.

Previously, re-acquisition of muscle mass with or without steroid use after periods of inactivity has been attributed to motor learning. However, this new data from the University of Oslo suggests that there is a cellular 'memory mechanism' within muscle of brief steroid users.

The team investigated the effects of steroids on muscle re-acquisition in mice and discovered greater muscle mass and more myonuclei which are essential components for muscle fibre function were apparent after returning to exercise.

Professor Kristian Gundersen explains how they carried out the study and the results found:

"Mice were briefly exposed to steroids which resulted in increased muscle mass and number of cell nuclei in the muscle fibres. Three months after withdrawal of the drug (approximately 15% of a mouse's life span) their muscles grew by 30% over six days following load exercise. The untreated mice grew insignificantly."

The findings might have consequences for the exclusion time of doping offenders as brief exposure to anabolic steroids might have long lasting performance-enhancing effects.

Prof Gundersen says:

"The results in our mice may correspond to the effects of steroids lasting for decades in humans given the same cellular 'muscle memory' mechanism. The new results might spur a debate on the current World Anti-Doping Agency (WADA) code in which the maximum exclusion time is currently two years." Additionally, the data suggests that strength training when young might be beneficial later in life since the ability to generate new myonuclei is impaired in the elderly.

Future studies should include human muscles and further investigation into the cellular and molecular mechanism for muscle memory.


'/>"/>

Contact: Lucy Holmes
LHolmes@physoc.org
44-020-726-95727
Wiley
Source:Eurekalert  

Page: 1

Related biology news :

1. NRC authors brief federal agencies on the state of polar regions
2. The Scars of Human Evolution briefing explores physical fallout from 2-footed walking
3. Frontiers news briefs: May 23
4. Frontiers news briefs May 30
5. Frontiers news briefs: June 6
6. Frontiers news briefs: 27 June
7. Frontiers news briefs: July 4
8. Frontiers news briefs: July 23
9. Frontiers news briefs: Aug. 13
10. Biometrics & Technology Sector Leaders Briefing: NXT-ID, Intel, Sony, Facebook, Dell
11. Reproductive health providers should discuss environmental exposure risks with patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Brief exposure to performance-enhancing drugs may be permanently 'remembered' by muscles
(Date:2/3/2016)... February 3, 2016 --> ... research report "Automated Fingerprint Identification System Market by Component ... Application (Banking & Finance, Government, Healthcare, and Transportation) and ... the market is expected to be worth USD 8.49 ... between 2015 and 2020. The transformation and technology evolution ...
(Date:2/3/2016)... 2016 http://www.researchandmarkets.com/research/d8zjcd/emotion_detection ... "Emotion Detection and Recognition Market by ... Software Tools (Facial Expression, Voice Recognition and ... - Global forecast to 2020" report ... http://www.researchandmarkets.com/research/d8zjcd/emotion_detection ) has announced the addition of ...
(Date:2/2/2016)... YORK , Feb. 2, 2016 ... of the bioinformatic market by reviewing the recent ... enabled tools that drive the field forward. Includes ... to: Identify the challenges and opportunities that ... providers and software solution developers, as well as ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... Feb. 11, 2016  Dovetail Genomics™ LLC today announced ... program for a planned metagenomic genome assembly service. ... metagenomic genome assembly method in a talk on Friday, ... & Technology conference in Orlando, Fla. ... complex datasets is difficult. Using its proprietary ...
(Date:2/11/2016)... ... 2016 , ... Global Stem Cells Group, has ... The new facility will provide advanced protocols and state-of-the-art techniques in cellular medicine, ... , The new GSCG clinic is headed by four prominent Ecuadorian physicians, including ...
(Date:2/10/2016)... , Feb.10, 2016 ASAE is introducing a ... Management Companies (AMC) the option of joining or renewing ... fee determined by staff size, every employee in any ... ASAE and reap all available member benefits.   ... new organizational membership options will allow organizations of any ...
(Date:2/10/2016)... ... February 10, 2016 , ... Benchmark Research, a fully-integrated network ... two long-standing principal investigators (PI) to the roles of Chief Medical Officer, Clinical ... Dr. Laurence Chu, a Benchmark Research PI in the Austin office, will assume ...
Breaking Biology Technology: