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Bridging the gap: Hope that all meningitis strains will be vaccinated for
Date:2/27/2013

ing of this bacterium has similar characteristics to a human protein found in the brain, and therefore if we used the same method, we would potentially create antibodies against the body's own protein."

ACP was identified from a previous study done by the team in Southampton, in which they analysed the types of protein that were present in the membrane that is found underneath the 'jelly-like' coat of the bacterium. The team believed that because these proteins might be exposed on the surface of the membrane, they could conceivably be targeted by the human immune system. The team confirmed that ACP was indeed exposed on the bacterium's surface and also that it was present in all the strains of meningococci that they were able to examine.

Dr Christodoulides adds: "We believe that ACP is potentially something that will bridge the gap that the new universal vaccine does not appear to cover and break through into the second generation of vaccines for Meningitis B."

Dr Christodoulides and his team will continue preclinical work with the potential vaccine with an aim of taking it to Phase 1 trials.


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Contact: Becky Attwood
r.attwood@soton.ac.uk
44-023-805-95457
University of Southampton
Source:Eurekalert

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