Navigation Links
Breathless babies: Preemies' lung function shows prolonged impairment
Date:12/14/2007

Many premature babies face serious health challenges, not the least of which is breathing. But now research suggests that even relatively healthy preemies confront deficits in lung function that last into their second year, if not longer.

We have shown that healthy preterm infants have reduced lung function in the first months of life that persists into the second year of life, said principle investigator of the research, Marcus Herbert Jones, M.D., Ph.D., professor in the Department of Pediatrics at Pontificia Universidade Catolica do Rio Grande do Sul in Brazil. Healthy infants born prematurely may have smaller sized airways relative to the lung volume, he explained.

The research was published in the second issue for December of the American Journal of Respiratory and Critical care medicine, published by the American Thoracic Society.

That premature infants have less well developed lungs than their full term counterparts is well established, but researchers were unsure if preemies underwent a catch-up period of lung function development. To determine if that was the case, Dr. Jones and colleagues recruited 26 preterm infants born between 30 and 34 weeks gestation and compared their lung development and function to that of full term infants at about 10 weeks of age, then again at an average age of 15 months.

They found that lung capacity and development relative to body size was similar between the groups, but airway function was consistently lower in the premature infants at both evaluations.

We were unable to detect a catch-up period during the study. There was no change in the rate of increase of lung function when compared to full term infants, said Dr. Jones.

Remarkably, the researchers also found that premature infants who had more fully developed lungs, thus less need for supplemental oxygen after birth, actually faced greater respiratory problems than those who required prolonged supplemental oxygen.

It is a counterintuitive finding, said Dr. Jones. My interpretation is that in preterm infants, supplemental oxygen may be a marker of a less mature lung, which may have a better long term respiratory prognosis than infants with accelerated maturation due to prenatal events such as infection and inflammation.

Maternal tobacco smoking was also associated with lower lung function in both premature and full term infants in both evaluations, suggesting a long lasting effect of smoke exposure on infant lung growth and development. The finding supports a number of other studies that have similarly found that maternal smoking adversely affects lung function in both full term and preterm infants.

While Dr. Jones and colleagues postulate that the preterm infants reduced lung function may be due to airways that do not develop at the same rate as their lung volume, they also highlight other possible explanations, including more compliant airways, increased bronchial tone, or decreased pulmonary elastic recoil, and advocate further research to determine why preterm infants face persistent deficits in lung function..

These subjects have decreased airway function not only in the first few months of life, but also at the one year follow-up evaluation, wrote Dr. Jones. The persistence of reduced expiratory flows in healthy preterm infants may contribute to their increased risk of respiratory illnesses early in life.


'/>"/>

Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related biology news :

1. Leading cause of death in preemies might be controlled by resetting a molecular switch
2. Geron Demonstrates hESC-derived cardiomyocytes improve heart function after myocardial infarction
3. Device helps patients survive, regain function til transplant
4. Specific brain protein required for nerve cell connections to form and function
5. Systems Biology poised to revolutionize the understanding of cell function and disease
6. Women more depressed and men more impulsive with reduced serotonin functioning
7. Researchers expand efforts to explore functional landscape of the human genome
8. The endocannabinoids: Functional roles and therapeutic opportunities
9. Elevated nitric oxide in blood is key to high altitude function for Tibetans
10. Children with gene show reduced cognitive function
11. Unlocking the function of enzymes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... Jan. 19, 2017 Sensory Inc ... and security for consumer electronics, and i ... systems and cybersecurity solutions, today announced a global ... financial institutions worldwide to bolster security of data ... secure user authentication platforms they offer, innerCore now ...
(Date:1/12/2017)... SAN DIEGO , Jan. 12, 2017  Trovagene, ... circulating tumor DNA (ctDNA) technologies, today announced that it ... Europe and the Middle ... biopsy tests.  This milestone marks the first wave of ... tests for urine and blood samples. The ...
(Date:1/11/2017)... , Jan. 11, 2017  Michael Johnson, co-founder of Visikol ... Capital Group, Inc., has been named to the elite "Forbes 30 ...  was one of 600 people in 20 fields nationwide to be ... of the 15,000 applicants were selected. ... He is currently a PhD candidate at Rutgers ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... ... ... FireflySci Inc. is a go-getter type of company that continues to grow ... main factors. The first is the amazing customer service that the FireflySci staff ... around the world. , 2016 was a tremendous sales year for FFS and much ...
(Date:1/19/2017)... 2017  Northwest Biotherapeutics, Inc. (OTCQB: NWBO) ("NW Bio"), ... for operable and inoperable solid tumor cancers, announced today ... of NW Bio, will present at the Phacilitate Immunotherapy ... Hyatt Regency Hotel in Miami, Florida ... entitled "New Therapeutic Approaches – Expanding the Reach of ...
(Date:1/18/2017)... OR (PRWEB) , ... January 18, 2017 , ... ... that provide essential device-to-computer interconnect using USB or PCI Express, announced the ZEM5310 ... Cyclone V E FPGA into a compact business-card sized form factor suitable for ...
(Date:1/18/2017)... Jan. 18, 2017 Applied BioMath ( ... to drug research and development, today announced that ... and CEO of Applied BioMath, will present at ... Modeling (BAGIM) Meeting on Thursday January 19, 2017 ... , MA.   Dr. Burke,s talk "Quantitative Modeling ...
Breaking Biology Technology: