Navigation Links
Breath analysis reliably indicates presence, level of infection in mice, UCI study finds
Date:8/1/2013

Irvine, Calif., July 31, 2013 Breath analysis may prove to be an accurate, noninvasive way to quickly determine the severity of bacterial and other infections, according to a UC Irvine study appearing online today in the open-access journal PLOS ONE.

Employing a chemical analysis method developed for air pollution testing, UC Irvine microbiologists and chemists were able to correlate inflammation levels in laboratory mice to the amount of naturally produced carbon monoxide and other gases in breath samples.

The findings point to human applications of this technology in emergency rooms and intensive care units, potentially augmenting or replacing blood tests.

"Breath analysis has been showing promise as a diagnostic tool in a number of chronic diseases," said Dr. Alan Barbour, professor of microbiology & molecular genetics and medicine. "This study provides the first evidence that it can be used for rapid clinical assessment of infections, which can lead to prompt institution of effective treatments."

Barbour collaborated with UC Irvine chemist Donald Blake, utilizing a gas analysis method devised for the Rowland-Blake lab's atmospheric chemistry research, which measures the level of trace gases that contribute to local and regional air pollution. It's one of the few research groups in the world recognized for its ability to gauge precisely at the parts-per-trillion level. Previous breath sampling work by the Rowland-Blake lab has involved diabetes, cystic fibrosis and kidney failure.

Barbour believed that breath analysis could additionally be used on infections, which elicit strong inflammatory responses in the body. Several compounds, or "biomarkers," are by-products of these responses. They can be identified in blood but also detected in exhaled breath.

Studying mice with bacterial blood infections, the researchers found that increases in the severity of infection elicited significantly higher amo
'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related biology news :

1. How much a single cell breathes
2. Microorganisms detected via breath test linked to body mass, fat accumulation
3. Vitamin D benefits breathing in tuberculosis patients
4. Biobatteries catch breath
5. Nemo helps anemone partner breath by fanning with his fins
6. Scientists trick iron-eating bacteria into breathing electrons instead
7. New equipment is breath of fresh air for childrens lung researchers
8. New analysis of premature infants heartbeats, breathing could be cues for leaving NICU
9. Trust in leaders, sense of belonging stir people to safeguard common goods, analysis shows
10. Major global analysis offers hope for saving the wild side of staple food crops
11. Artifact suppression and analysis of brain activities with EEG signals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2014)... PROVO, Utah , Dec. 4, 2014  Tute ... has raised $2.3 million in Series A1 funding led ... angel investors also participated in the investment round. ... as the healthcare community adopts next-generation sequencing and seeks ... disease," said Reid Robison , MD MBA, and ...
(Date:11/21/2014)... -- Earlier this year Donald Spector , Chairman of ... the most prolific inventors in the world, got a ... to third party agencies. Spector envisioned this technology even ... earliest known patents in this area. Now major technology ... care, elder care and hospital applications. This technology has ...
(Date:11/18/2014)... 17, 2014   News Highlights: ... to develop The Partners Data Lake, an agile ... Data Lake will allow researcher and clinicians to ... and the lives of patients , The ... activities across the Partners system, breaking down physical ...
Breaking Biology News(10 mins):Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5
... Described as a hotspot of botanical diversity, there are ... Several thousand of them are used by traditional healers ... of problems from the common cold to serious diseases ... are will be the focus of The International Center ...
... owners have a new weapon in their pest management ... kills its host, has proven to be quite effective ... tiny pest-devouring insects are considered to be powerful "biocontrol ... management applications. Jean Pierre Kapongo, Ph.D., an entomologist ...
... when you,ve reached the top of a mountain and you ... to plants and animals, as their habitats slowly shift to ... is you can,t go anywhere. Habitats shrink to the vanishing ... to be played out repeatedly and at an accelerating rate ...
Cached Biology News:Study of African traditional medicine will begin world-first clinical trial 2Study of African traditional medicine will begin world-first clinical trial 3Stanford researchers say climate change will significantly increase impending bird extinctions 2Stanford researchers say climate change will significantly increase impending bird extinctions 3Stanford researchers say climate change will significantly increase impending bird extinctions 4
(Date:12/17/2014)... 2014 Gene synthesis and bioengineering ... entered into a technology access and services agreement ... DNA2.0’s proprietary protein engineering technology, known as “ProteinGPS®” ... are extremely excited that the global leader ADM ... proprietary bioengineering technology has now been validated through ...
(Date:12/17/2014)... -- Vermillion, Inc. (NASDAQ: VRML ), a bio-analytic ... next step in its expanded strategy to rebuild the ... naming of current Chief Operating Officer, Valerie Palmieri ... Chairman of the Board and CEO James LaFrance ... are effective January 1, 2015. "Jim and ...
(Date:12/17/2014)... Md. , Dec. 17, 2014 CASI ... company dedicated to the acquisition, development and commercialization of ... for the global market with a primary commercial focus ... it has been granted a Type C meeting with ... the meeting will be held in February 2015.  During ...
(Date:12/17/2014)... LEXINGTON, Mass. , Dec. 17, 2014   ... a biopharmaceutical company developing therapeutic products for rare disorders, ... Healthcare Conference being held in San Francisco, ... , President and Chief Executive Officer, will present on ... p.m. EST).  The presentation will be webcast live and ...
Breaking Biology Technology:ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 3Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 4CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 2CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 3CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 4CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 5
... (Nasdaq: NTII ), today announced it will release,its ... September,16, 2008., The Company will also host a ... year-end call are as follows:, -- Date: ... ET, 9:30 a.m. CT, 7:30 a.m. PT -- ...
... Heightened interest in therapeutic efficiency, quality and safety of food ... the biotechnology market. Biopharmaceuticals is poised to experience spiraling growth ... stream of products presently in the pipeline. , ... ...
... Sinovac Biotech Ltd. (Amex:,SVA), a leading provider of ... Anflu(R), a seasonal influenza vaccine, for 2008-2009 Flu ... only split influenza,vaccine produced without preservatives in China. ... its established sales force to,promote the adult dosage ...
Cached Biology Technology:Neurobiological Technologies Announces Dates for 2008 Fiscal Year End Financial Results Conference Call and Presentation at MCF Investor Summit 2Long-Term Investments Remain Critical to Biotechnology Industry Growth, According to a New Report by Global Industry Analysts 2Long-Term Investments Remain Critical to Biotechnology Industry Growth, According to a New Report by Global Industry Analysts 3Long-Term Investments Remain Critical to Biotechnology Industry Growth, According to a New Report by Global Industry Analysts 4Sinovac Launches Seasonal Influenza Vaccine Anflu(R) for 2008-2009 Flu Season 2Sinovac Launches Seasonal Influenza Vaccine Anflu(R) for 2008-2009 Flu Season 3
Request Info...
Invitrogen's Calcium Phosphate Transfection Kit provides high-quality reagents to enable the introduction of DNA into tissue culture cells via calcium phosphate co-precipitation....
Request Info...
...
Biology Products: