Navigation Links
Breast-fed babies' gut microbes contribute to healthy immune systems
Date:5/21/2012

URBANA A new multi-university study reports that differences in bacterial colonization of the infant gut in formula-fed and breast-fed babies lead to changes in the expression of genes involved in the infant's immune system.

The study, published in the April 30 issue of BioMed Central's open access journal Genome Biology, is an Editor's Pick. The research was a joint effort of University of Illinois, Texas A&M University, Miami University, and University of Arkansas scientists.

"This study provides a first insight into the interactions between microbes and the developing infant and how these interactions are affected by diet. It also demonstrates the power of new experimental and analytical approaches that enable the simultaneous analysis of the microbiome and the host response," said Mihai Pop of the University of Maryland in a review of the study for the publishing journal.

There is strong evidence that the colonization of the body by microbes has an important influence on the development of infants' immune systems, he added.

In the study, the researchers compared the genes expressed in cells from the intestines of three-month-old exclusively breast-fed or formula-fed infants and related this to their gut microbes. The human intestine is lined by epithelial cells that process nutrients and provide the first line of defense against food antigens and pathogens. Approximately one-sixth of the intestinal epithelial cells are shed every day into feces, providing a non-invasive picture of what is going on inside the gut.

The baby's gene expression profile was compared to the genes contained in the microbes in its gut, or the bacterial metagenome. This analysis provides a picture of who the bacteria are and what they are doing.

The study showed that babies that had been fed only breast milk had a more diverse bacterial colonization than formula-fed babies. The scientists also found a link between the expression of genes in the bacteria and genes of the immune system in the baby.

"While we found that the microbiome of breast-fed infants is significantly enriched in genes associated with 'virulence,' including resistance to antibiotics and toxic compounds, we also found a correlation between bacterial pathogenicity and the expression of host genes associated with immune and defense mechanisms," said Robert Chapkin of Texas A&M University.

Iddo Friedberg of Miami University in Ohio said that the differences in virulence genes probably do not reflect an infection. "The breast-fed babies had a larger complement of gram-negative bacteria than the formula-fed babies. Gram-negative bacteria have genes that, although classified as 'virulent,' can activate the immune system but not cause an infection in the process. We are now studying this finding in greater depth," he said.

"The findings show that human milk feeding promotes the beneficial microbe population in the gut and crosstalk between these bacteria and the immune system of the infant and are helping us to define exactly why breast is best," said U of I scientist Sharon Donovan.


'/>"/>
Contact: Phyllis Picklesimer
p-pickle@illinois.edu
217-244-2827
University of Illinois College of Agricultural, Consumer and Environmental Sciences
Source:Eurekalert

Related biology news :

1. Big-mouthed babies drove the evolution of giant island snakes
2. Vitamin D for pregnant women and babies -- how much is enough?
3. Lizard moms may prepare their babies for a stressful world
4. 2 servings of salmon a week is healthy for pregnant women and their babies
5. New infant formula ingredients boost babies immunity by feeding their gut bacteria
6. Babies are born with intuitive physics knowledge, says MU researcher
7. Breastfeeding saved babies in 19th century Montreal
8. Barracuda babies: Novel study sheds light on early life of prolific predator
9. Babies born with no eyes: Scientists identify genetic cause
10. Premature babies at risk of ill health in later life, research suggests
11. Sleep disruption for breastfed babies is temporary
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2017)... , May 5, 2017 ... just announced a new breakthrough in biometric authentication ... exploits quantum mechanical properties to perform biometric authentication. These ... smart semiconductor material created by Ram Group and ... finance, entertainment, transportation, supply chains and security. Ram ...
(Date:4/17/2017)... 17, 2017 NXT-ID, Inc. (NASDAQ: NXTD ... filing of its 2016 Annual Report on Form 10-K on Thursday ... ... available in the Investor Relations section of the Company,s website at ... website at http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/11/2017)... Research and Markets has announced the addition ... their offering. ... tracking market to grow at a CAGR of 30.37% during the ... 2017-2021, has been prepared based on an in-depth market analysis with ... its growth prospects over the coming years. The report also includes ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... announced today that they have entered into a multiyear collaboration to identify and ... researchers with additional tools for gene editing across all applications. , Under the ...
(Date:10/12/2017)... ... 12, 2017 , ... AMRI, a global contract research, development ... patient outcomes and quality of life, will now be offering its impurity solutions ... new regulatory requirements for all new drug products, including the finalization of ICH ...
(Date:10/11/2017)... LINDA, CA (PRWEB) , ... October 11, 2017 ... ... to upregulate any gene in its endogenous context, enabling overexpression experiments and avoiding ... (CRISPRa) system with small RNA guides is transformative for performing systematic gain-of-function studies. ...
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia Inc ., ... a Webinar titled, “Pathology is going digital. Is your lab ready?” with Dr. ... best practices and how Proscia improves lab economics and realizes an increase in ...
Breaking Biology Technology: