Navigation Links
Breast density linked to increased risk of subsequent breast cancer
Date:10/6/2010

PHILADELPHIA Researchers at Kaiser Permanente have found that patients with a very early form of breast cancer (ductal carcinoma in situ or DCIS) who have higher mammographic density may be at increased risk for subsequent breast cancer, especially in the breast opposite to the one with the initial cancer.

These study results are published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

Mammographic density refers to the proportion of the breast that appears dense on a mammogram; it is one of the strongest risk factors for primary invasive breast cancer. On a mammogram, dense tissue looks white while non-dense tissue looks dark grey. The dense area consists primarily of breast ducts and connective tissue, while the non-dense tissue is mostly fat.

Results of a previous study showed that patients with DCIS who had higher mammographic density had about two to three times increased risk for a second breast cancer.

To confirm her earlier findings, Laurel A. Habel, Ph.D., research scientist at Kaiser Permanente's Division of Research, and colleagues conducted a larger cohort study that consisted of 935 women diagnosed with DCIS who were treated with breast-conserving surgery (i.e., not a mastectomy) between 1990 and 1997 at Kaiser Permanente of Northern California.

After reviewing medical records, evaluating mammograms at diagnosis and then calculating the risk of subsequent breast cancer events during follow-up, the researchers found that risk of second breast cancer appeared to be elevated among the women with higher density.

"While risk was elevated for both breasts, the increase was greatest and most consistent for the breast opposite to the one with the initial cancer," Habel said.

Of the patients, 164 had a subsequent ipsilateral breast cancer (breast cancer on the original cancer-affected breast) and 59 had a new primary cancer in the other breast during follow-up. The researchers anticipated finding an increased risk of a subsequent cancer in the breast with the initial cancer, as well as in the opposite breast.

Habel stressed that additional studies will be needed to confirm these risk estimates and determine whether information on density can aid in risk assessment and treatment options.

"Information on mammographic density may help with treatment decisions for ductal carcinoma in situ patients," she said. "While it's not a strong enough risk factor on its own, it may be possible to combine it with other factors to improve risk assessment and inform treatment decisions."


'/>"/>

Contact: Tara Yates
tara.yates@aacr.org
267-646-0558
American Association for Cancer Research
Source:Eurekalert

Related biology news :

1. Breast cancer treatment resistance linked to signaling pathway
2. The dietary supplement genistein can undermine breast cancer treatment
3. Breast cancer cells recycle to escape death by hormonal therapy
4. Second lumpectomy for breast cancer reduces survival rates
5. Study looks at psychological impact of gene test for breast cancer
6. SNM releases new fact sheet on breast cancer and molecular imaging
7. Study links nicotine with breast cancer growth and spread
8. UC Davis researchers discover a key to aggressive breast cancer
9. CTRC-AACR San Antonio Breast Cancer Symposium
10. Einstein researchers develop a new way to study how breast cancer spreads
11. Mayo researchers identify dangerous two-faced protein crucial to breast cancer spread and growth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/14/2016)... CLARA, Calif. , Nov. 14, 2016 ... the biometric identification market, Frost & Sullivan ... Frost & Sullivan Award for Visionary Innovation ... player in the biometric identification market by ... multi-modal verification solution for instant, seamless, and ...
(Date:6/22/2016)... American College of Medical Genetics and Genomics was once again ... of the fastest-growing trade shows during the Fastest 50 Awards ... Las Vegas . Winners are ... of the following categories: net square feet of paid exhibit ... 2015 ACMG Annual Meeting was ranked 23 out of 50 ...
(Date:6/22/2016)... , June 22, 2016 On Monday, ... call to industry to share solutions for the Biometric ... U.S. Customs and Border Protection (CBP), explains that CBP ... are departing the United States , ... and to defeat imposters. Logo - ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... SAN DIEGO , Dec. 8, 2016 /PRNewswire-USNewswire/ ... treatments for congestive heart failure and type 2 ... license for a novel adeno-associated virus (AAV) vector ... Kay , M.D., Ph.D., at Stanford University. The ... of its paracrine gene therapy product pipeline. ...
(Date:12/8/2016)... December 8, 2016 Oxford Gene ... customisable SureSeqâ„¢ NGS panel range with the launch of the ... cost-effective study of variants in familial hypercholesterolemia (FH). The panel ... detection on a single small panel and allows customisation by ... includes all exons for LDLR , P ...
(Date:12/8/2016)... , ... December 08, 2016 , ... This CAST literature ... for biotech crops. The authors focus on the economic effects in countries that are ... of new biotech crops and the resultant risk of low level presence (LLP) puts ...
(Date:12/8/2016)... Dec. 8, 2016 Eutilex Co. Ltd. today ... (US $18.9M) Series A financing. This financing round included ... Venture and SNU Bio Angel. This new funding brings ... KRW (US $27.7M) since its founding in 2015. ... the development and commercialization of its immuno-oncology programs, expand ...
Breaking Biology Technology: