Navigation Links
Breast cancer risk gene discovery fast tracked by new technology
Date:3/29/2012

ll unaccounted for.

"Research indicates that no single gene is likely to account for a large proportion of the remaining unexplained genetic susceptibility to breast cancer," Professor Southey said.

"Although mutations in XRCC2 are rare, it is most likely that the remaining unknown breast cancer susceptibility genes will account for similar small proportions of the disease."

Initially, using massively parallel sequencing, researchers identified XRCC2 mutations in two families (in Melbourne and the Netherlands). This was followed by a larger series of studies using DNA from blood samples of 689 families with multiple members affected by breast cancer, and from 1308 women who were affected at an early age by breast cancer and recruited from the general population, as well as 1120 controls.

More XRCC2 mutations were detected in the breast cancer cases but not in the controls. These additional studies were conducted in Melbourne and at the International Agency for Research on Cancer (IARC) in France.

Co-first author Dr Daniel Park of the University's Department of Pathology (with Dr Fabienne Lesueur of IARC) said the study demonstrated the power of massively parallel sequencing for discovering susceptibility genes for common, complex diseases like breast cancer.

"Our study approach could be applied to many other common, complex diseases with components of unexplained heritability, such as colorectal and prostate cancers," he said.

Professor Southey oversaw this work with two long-standing collaborators and experts in the field of breast cancer genetics, Associate Professor Sean Tavtigian and Professor David Goldgar at the University of Utah.


'/>"/>
Contact: Rebecca Scott
rebeccas@unimelb.edu.au
61-383-440-181
University of Melbourne
Source:Eurekalert

Page: 1 2

Related biology news :

1. Protein jailbreak helps breast cancer cells live
2. Study details on-off switch that promotes or suppresses breast cancer
3. Breast cancer spread triggered by a cleaver-wielding protein on cancer cells surface
4. Some breast cancer spread may be triggered by a protein, study shows
5. Researchers identify possible receptor for key breast cancer regulator
6. ISG15: A novel therapeutic target to slow breast cancer cell motility
7. Cell-CT: A new dimension in breast cancer research
8. Breastfeeding promotes healthy growth
9. Breastfeeding saved babies in 19th century Montreal
10. MRI may be noninvasive method to measure breast cancer prognosis
11. New Achilles heel in breast cancer: Tumor cell mitochondria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... POINT ROBERTS, Washington , January 20, 2015 ... sectors including technology and tech stocks, releases video from the ... pickpocket and security consultant Apollo Robbins . ... about the Wocket™ biometric smart wallet, a product of NXT-ID, ...
(Date:1/22/2015)... , Europe,s ... European Patent Office to present a video retrospective of the most ... featured: Christofer Toumazou and Sophie Wilson   ... of the Award   Starting on 22 January 2015 ...
(Date:1/22/2015)... , Jan. 22, 2015   EyeLock, Inc. , a market ... appointed Steve Gerber to the new role of ... responsible for leading development of mobile platforms and wearable solutions ... success and innovation in the semiconductor industry to his role ...
Breaking Biology News(10 mins):Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 2
... BOSTON, Nov. 17, 2010 /PRNewswire/ -- ... a leading global biopharmaceutical services provider, today announced that ... studies in patient populations during the past three years. ... phase units worldwide, enrolled more than 3,000 patients.   ...
... results from a study by neuroscientists at Rush University Medical ... exhibit a specific structural change in the brain that can ... identify those who would most benefit from early intervention. ... meeting for the Society of Neuroscience in San Diego, Calif., ...
... on the brink of an era of mass extinctions ... species suddenly disappeared from the Earth, reports a biologist ... establishment of a species-rescue program for Haiti,s threatened frogs ... the next few decades, many Haitian species of plants ...
Cached Biology News:PAREXEL Completes 200 Patient Studies In Its Early Phase Units Over Three Years 2PAREXEL Completes 200 Patient Studies In Its Early Phase Units Over Three Years 3PAREXEL Completes 200 Patient Studies In Its Early Phase Units Over Three Years 4MRI scans show structural brain changes in people at risk for Alzheimer's disease 2Rescue missions underway to save Haiti's species from mass extinctions 2Rescue missions underway to save Haiti's species from mass extinctions 3Rescue missions underway to save Haiti's species from mass extinctions 4Rescue missions underway to save Haiti's species from mass extinctions 5
(Date:1/22/2015)... (PRWEB) January 22, 2015 GEA Niro ... table top laboratory homogenizer, the PandaPLUS 2000, which is ... nanoemulsions , and cell disruption . This compact ... products, fruit juices, liquid food, food additives and ingredients ...
(Date:1/22/2015)... January 22, 2015 Protocol Networks brings ... growing team of brand-neutral, independent consultants, Protocol Networks has ... explained that over the years, his company has attracted ... Town of Plainfield, as well as others. With the ...
(Date:1/22/2015)... Dr. Greg Leyer of UAS Labs recently ... Supplements Pre-Conference seminar on probiotics in San Diego, CA. ... education conference for health care professionals. This year’s pre-conference seminar ... probiotics in health. Dr. Leyer spoke about the emerging topics ...
(Date:1/22/2015)... 22 de enero de 2015  El Dr. Paul ... llamada a nominaciones para 2015. Este prestigioso premio reconoce ... tiene el potencial para hacer, contribuciones destacadas para la ... hasta el 15 de marzo de 2015 a través ...
Breaking Biology Technology:GEA Niro Soavi Announces the PandaPLUS 2000 Homogenizer for Processing New Applications for Nanoemulsions and Cell Disruption 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4
... Feb. 18 Pharmos Corporation (Nasdaq: PARS ... agreement with an Israel based company, Reperio Pharmaceuticals Ltd. ... technical know how related to the compound known as ... are synthetic compounds which belong to the class of ...
... Commissioned in Coming WeeksLAKE MARY, Fla., Feb. 18 ... NGBF ) ("New Generation Biofuels" or ... today announced that construction of the Company,s first ... completion, and operations are expected to commence within ...
... Sullivan, the,Growth Partnership Company, reaffirms its position that the ... unprecedented US $1 trillion,stimulus package from the US government ... (Logo: http://www.newscom.com/cgi-bin/prnh/20081117/FSLOGO ) , ... serving to convince,businesses and consumers that we can get ...
Cached Biology Technology:Pharmos Announces Agreement to Sell Certain CB2 Selective Agonists 2Pharmos Announces Agreement to Sell Certain CB2 Selective Agonists 3New Generation Biofuels Completes Construction of Baltimore Facility 2New Generation Biofuels Completes Construction of Baltimore Facility 3Frost & Sullivan Forecasts Early Rebound: Strong Growth Ahead for Global Economy 2
Makes gels easy to load and track during electrophoresis. 10X concentrate of Bromophenol Blue, glycerol solution....
Request Info...
Request Info...
Request Info...
Biology Products: