In other results presented at IMPAKT, the researchers investigated the prognostic performance of known gene expression signatures according to age.
"As breast cancer arising below the age of 40 is relatively uncommon, we lack information on whether different gene signatures provide prognostic information in a uniform way across different age groups," Dr Azim said. "We tested three proliferation-related signatures and found that they add prognostic information in all patients with ER+ breast cancer, irrespective of age."
"This is clinically relevant as it underscores that these gene signatures could identify women below the age of 40 with ER+ disease who are at a low risk of relapse independent of clinical prognostic tools," Dr Azim explained.
Commenting on the recently published study, which he was not involved in, Prof Bryan Hennessy, from Beaumont Hospital in Dublin, said: "Young women with breast cancer tend to have a poorer prognosis. This study provides evidence that breast cancer in young women is associated with unique underlying biologic processes, highlighting important information that may allow us to design tailored therapy approaches to improve outcomes in this population."
|Contact: Vanessa Pavinato|
European Society for Medical Oncology