Navigation Links
Breast cancer in young women: A distinct disease
Date:5/3/2012

Breast cancer in young women is a biologically unique disease that requires customized management strategies, researchers report at the 4th IMPAKT Breast Cancer Conference, in Brussels, Belgium.

The reported findings have potentially important implications for treatment, because breast cancer in young women is often aggressive and diagnosed at an advanced stage, meaning the prognosis for these patients is often poor.

Dr. Hatem A. Azim Jr., a medical oncologist from Institut Jules Bordet in Brussels, and colleagues showed that breast cancer in women forty-years or younger is enriched with the aggressive basal-like tumors. Moreover, these patients have a significantly higher risk of relapse independent of stage, histological grade, breast cancer molecular subtypes and treatment received.

A subgroup analysis showed a particularly poor trend in patients with luminal tumors, i.e. estrogen receptor positive. "While some investigators could refer this to poor compliance of young women to hormonal therapies, we performed another analysis in 1,188 women who did not receive any systemic therapy and indeed found significant poor outcome in young women both in luminal-A and luminal-B tumors," Dr Azim said. Luminal-A cancers are ER+ and low-grade, while Luminal-B cancers are ER+ but often high grade.

To elucidate the possible reasons behind the poor outcome in young women, Dr Azim and co-workers went on to study the expression of a variety of genes in women with breast cancer to see if they correlated with age. They adjusted their findings to take into account the size of the tumor at diagnosis, whether the disease had spread to lymph nodes and breast cancer molecular subtype, in addition to other variables.

The researchers performed their analysis on two independent datasets, including 1,188 and 2,334 patients, and found the same results in both cases.

"What we found was that even after adjustment for these parameters
'/>"/>

Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Fourth IMPAKT Breast Cancer Conference
2. High levels of TRAIL protein in breast milk might contribute to anticancer activity
3. Researchers identified a protein useful in predicting the risk of pulmonary metastases in breast cancer patients
4. Detecting breast cancers fingerprint in a droplet of blood
5. Mechanism found connecting metastatic breast cancer and arthritis
6. A new breast cancer susceptibility gene
7. Breast cancer risk gene discovery fast tracked by new technology
8. Protein jailbreak helps breast cancer cells live
9. Study details on-off switch that promotes or suppresses breast cancer
10. Breast cancer spread triggered by a cleaver-wielding protein on cancer cells surface
11. Some breast cancer spread may be triggered by a protein, study shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... thousands of years has adapted to the arctic cold, and ... cold dangerous for you. , This is happening to the ... provoking substance, called nonylphenol, comes from the use of certain ... a endocrine disruptor, but when entering the worm it has ... the cells in its body from cold damage. , ...
(Date:9/18/2014)... PULLMAN, Wash. - Washington State University researchers have developed ... sediment to power waste cleanup in rural areas. ... lead to an inexpensive and quick way to clean ... treatment plants while reducing pollution. , Professor Haluk ... College of Engineering and Architecture discuss the system in ...
(Date:9/18/2014)... Colo., USA Miranda, a small, icy moon of ... enigmatic bodies in the solar system. Despite its relatively ... of intense resurfacing that resulted in the formation of ... polygonal-shaped regions called coronae. , These coronae are ... at least 200 km across. Arden corona, the largest, ...
Breaking Biology News(10 mins):Environmental pollutants make worms susceptible to cold 2Environmental pollutants make worms susceptible to cold 3Researchers develop unique waste cleanup for rural areas 2Miranda: An icy moon deformed by tidal heating 2Miranda: An icy moon deformed by tidal heating 3Miranda: An icy moon deformed by tidal heating 4Miranda: An icy moon deformed by tidal heating 5Miranda: An icy moon deformed by tidal heating 6Miranda: An icy moon deformed by tidal heating 7
... WASHINGTON The U.S. Environmental Protection Agency (EPA) ... EPA is releasing a database, called ToxRefDB, which allows ... thousands of toxicity testing results on hundreds of chemicals. ... results. "Tens of thousands of chemicals are in ...
... This release is available in German . 48 ... spray at the start of the experiment, the other half a ... charged situations in the form of a crying child, a girl ... then invited to express the depth of feeling they experienced for ...
... crawla bug that crawls onto your lips while you sleep, ... then gorges on your blood. And if that,s not insult ... potentially deadly disease. Now Jean-Paul Paluzzi, a PhD ... that manipulating physiology to prevent the insects from leaving their ...
Cached Biology News:US Environmental Protection Agency opens access to chemical information 2Hormone spray improves male sensitivity 2The kiss of death: Research targets lethal disease spread by insect that bites lips 2
(Date:9/19/2014)... 19, 2014 Cereal grain scientists, ... will gather October 5–8, 2014, for the AACC ... Convention Center in Providence, Rhode Island. The comprehensive ... of food scientists, chemists, microbiologists, nutritionists, and those ... production management. To date, 1,000 attendees have registered ...
(Date:9/19/2014)... -- The new , Healthcare and Life Sciences ... on PharmaBoardroom.com for free download , looks ... Spanish economy in 2009, and the austerity measures that followed, ... in times of trouble. "Despite the crisis, ... market, and the general conditions to invest are favorable to ...
(Date:9/18/2014)... -- About POCT POCT, also ... laboratory. It helps in making fast clinical decisions, ... POCT is gaining popularity due to the increasing ... diabetes, heart disease, and obesity. It is generally ... minimize errors during the diagnosis of patients. POCT ...
(Date:9/18/2014)... KEEGO HARBOR, Mich. , Sept. 18, 2014  Health ... -based biotech firm investigating early-stage algae bioactive compounds and metabolic ... member to the company,s board of directors. Ms. Nola ... executive and investment advisor joined the board effective September 17, ... have Ms. Masterson agree to join our board," states ...
Breaking Biology Technology:Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 2Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 3PharmaBoardroom Releases New Spain Pharmaceuticals Report 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 3POCT Market in China 2014-2018 2Health Enhancement Announces New Board Member In Advance Of Annual Shareholder Meeting 2
... the leading,management consulting firm specializing in the pharmaceutical ... Practice will,conduct two workshops at the 44th Drug ... 22 to 26, 2008, at the Boston Convention ... lead a workshop that examines best,practices for accelerated ...
... Xenon,Pharmaceuticals Inc., a drug discovery and development company, ... the Promising Early Stage,Company of the Year Award by ... are delighted to have received this prestigious award, one ... Simon,Pimstone, Xenon,s President and CEO. "This honor is important ...
... The Netherlands, June 17 , - Equens and ... payment processor Equens and supermarket chain Albert Heijn,will begin ... For a period of,six months, customers of Albert Heijn ... fingertips. The objective of the pilot is to,investigate the ...
Cached Biology Technology:Campbell Alliance Clinical Development Practice to Conduct Two Workshops at 44th DIA Annual Meeting 2Campbell Alliance Clinical Development Practice to Conduct Two Workshops at 44th DIA Annual Meeting 3Campbell Alliance Clinical Development Practice to Conduct Two Workshops at 44th DIA Annual Meeting 4Start of First Fingertip Payment Pilot in the Netherlands 2Start of First Fingertip Payment Pilot in the Netherlands 3
... HV high-voltage power supply, with temperature probe, 100-120 ... 5,000 V, 500 mA, and 400 W. The ... between 0 and 90 degrees C during electrophoresis. ... Power cord and instructions are provided. Dimensions are ...
... cooling coil, Trans-Blot cell, provides ... high-intensity, and extended electrophoretic transfer ... Trans-Blot cell. Use of the ... to an external water recirculator, ...
... a wide range of next-generation features into ... new standard for flexible laboratory solutions. It ... including pipetting, dilution, dispensing, and integrations ... powerful and flexible as it is efficient ...
... The Biomek FX P is the latest ... design for greater positional accuracy and increased robustness, ... any application. It can be configured with either ... deck capacity, the Biomek FX P sets ...
Biology Products: