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Breast cancer drug fulvestrant appears more effective in the presence of CK8 and CK18
Date:3/10/2010

ehand to be resistant or unresponsive to fulvestrant, the doctor may prevent some of the commonly reported side effects seen with the drug.

Nephew said that it wouldn't be easy for physicians to simply order a separate test that analyzes biopsied tissue for the presence of CK8 and CK18.

"It would require a few things a typical hospital doesn't have on hand," Nephew said. "But we're currently investigating how to do that. We also need to be able to show that the expression of the two cytokeratins can be prognostic of fulvestrant's effectiveness. To that end we are talking with George Sledge at the Indianapolis campus about the feasibility of clinical studies. That would be the next step."

George Sledge Jr. is the Ballve-Lantero Professor of Hematology/Oncology at the IU School of Medicine's Melvin and Bren Simon Cancer Center.

When the study was conducted, report coauthors Xinghua Long and Meiyun Fan were at IU Bloomington as a Ph.D. student and a postdoctoral fellow, respectively. The research was funded with grants from the National Cancer Institute's Integrative Cancer Biology Program, the Walther Cancer Foundation, and the National Natural Science Foundation of China.


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Contact: David Bricker
brickerd@indiana.edu
812-856-9035
Indiana University
Source:Eurekalert  

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