Navigation Links
Breast cancer drug fulvestrant appears more effective in the presence of CK8 and CK18
Date:3/10/2010

s estrogen's effects.

Although fulvestrant has been used to treat cancer since the late 1980s, and is now commonly prescribed as a second-line defense against metastatic cancer cells, how the drug works is still not completely understood. Nephew said one of the aims of the research is to clarify fulvestrant's biochemistry, and understand why cancer cells eventually become unresponsive to the drug.

Second-line breast cancer therapies are employed when first-line approaches (tamoxifen, for example) don't work or stop working.

After conducting analyses of different cell lines and assaying gene and protein activity, Nephew, Xinghua Long (now a faculty member at Jiangnan University), and Meiyun Fan (now an assistant professor at the University of Tennessee-Memphis) believe they are able to present a compelling model for fulvestrant's action. The scientists believe that when fulvestrant encounters ER-alpha and binds to the receptor, the receptor forms a two-protein complex either with another ER-alpha -- or with ER-beta, a related but different estrogen receptor. The alpha-alpha or alpha-beta "dimer" is then removed to the nuclear matrix, where it binds to CK8 and CK18. It's the binding of ER-alpha to the nuclear matrix that would seem to signal protein-killing proteases to destroy ER-alpha. As the number of available estrogen receptors plummets, the connection between estrogen and cancer-related gene activity is weakened, and estrogen can no longer contribute to the growth of cancer cells.

Because many drug treatments can have a severely negative impact on quality of life, Nephew said fulvestrant and other cancer drugs should only be prescribed when their use is associated with a reasonable chance of successful outcomes. However, compared to frequently prescribed endocrine treatments for advanced disease like tamoxifen, anastrozole, letrozole and exemestane, fulvestrant is well tolerated. If biopsied cancer cells can be shown befor
'/>"/>

Contact: David Bricker
brickerd@indiana.edu
812-856-9035
Indiana University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Newly created cancer stem cells could aid breast cancer research
2. Linchpin gene may be useful target for new breast cancer therapies
3. Dietary calcium could possibly prevent the spread of breast cancer to bone
4. Researchers find new gene linked to breast cancer
5. Analysis of breast and colon cancer genes finds many areas of differences between tumors
6. Genome update defines landscape of breast and colon cancers
7. AACR, BCRF award inaugural grants in translational breast cancer research
8. Enhanced DNA-repair mechanism can cause breast cancer
9. Einstein researchers receive grants totaling $700,000 for innovative breast cancer research
10. Breast cancer research and inkjet tissue printing get NSF boost
11. Breastfeeding boost IQ in infants with helpful genetic variant
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Breast cancer drug fulvestrant appears more effective in the presence of CK8 and CK18
(Date:12/19/2014)... 18, 2014 Research and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) ... North America Perimeter Security Systems Market" report to their ... The North American perimeter security market is estimated to grow ... the U.S. market holds a larger share in this market, ...
(Date:12/17/2014)... Dec. 15, 2014  HITLAB SM announced today its ... confirm its adherence to current U.S. Food and Drug ... regulated smart device and smart phone application trials utilizing ... "HITLAB is determined to improve global healthcare ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition of the ... to their offering. One major trend ... continuous advances in technology, it is important to upgrade ...
Breaking Biology News(10 mins):Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... The world,s top scientists and clinicians in the ... their latest research findings at the 58th Annual ... from Tuesday, November 11, through Saturday, November,15, 2008, ... ASHG is the primary professional membership organization for ...
... relationship between stem cell potency and the metabolic rate of ... active mitochondria also have a greater capacity to differentiate and ... appearing this week in JBC, could lead to methods of ... use and may provide some insights into the role of ...
... Investigators from the Herman B Wells Center for Pediatric ... on a family of blood proteins that they hope ... in children and adults. Their findings may one ... multiple myeloma and other cancers of the blood. The ...
Cached Biology News:The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia 2The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia 3The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia 4The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia 5On the trail of a targeted therapy for blood cancers 2
(Date:1/22/2015)... January 22, 2015 Controlled Substance Compliance ... which helps companies check the legal requirements around using ... to China. , As their international operations expand ... adopting software solutions built as a result of the ...
(Date:1/22/2015)... , Jan. 22. 2015  Varian Medical Systems (NYSE: ... has been honored for its commitment to sustainability with inclusion ... Varian is the highest ranked healthcare equipment company among the ... during the World Economic Forum at Davos, Switzerland ...
(Date:12/24/2014)... NEW YORK , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, ... in critical areas, announced the closing of an underwritten public ... purchase up to an aggregate 3,500,000 shares of common stock, ... per warrant.  The warrants have a per share exercise price ...
(Date:12/24/2014)... MA (PRWEB) December 23, 2014 Earlier this ... L. Sherley, director of the Adult Stem Cell Technology Center, ... and under appreciated unique property of adult tissue stem cells. ... in the Past, Important for the Future,” embodied the essence ...
Breaking Biology Technology:Global Compliance Service for Controlled Substances to Expand to China 2Varian Honored Among World's 100 Most Sustainable Corporations 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4
... Calif., Aug. 23 Nektar,Therapeutics (Nasdaq: NKTR ) ... President and CFO. Harkness reports to Nektar President and,CEO ... member of the company,s,new management team. "With his ... addition to the leadership team at Nektar," Robin said. ...
... -- Revenue increased 28% over the prior comparable period to A$44.4 ... over the prior comparable period to A$4.6 million ... period to A$2.5 million from A$2.0 million ... prior comparable period including one-off items -- ...
... to RFI, ,Therapeutic ... Agents, SCOTTSDALE, Ariz., Aug. 23 Research ... subsidiary of IR BioSciences Holdings, Inc. (OTC Bulletin ... to a Request for,Information (RFI) from the Defense ...
Cached Biology Technology:Nektar Therapeutics Appoints Tim Harkness as Chief Financial Officer 2Nektar Therapeutics Appoints Tim Harkness as Chief Financial Officer 3Ellex FY2007 Year End Results 2Ellex FY2007 Year End Results 3ImmuneRegen Responds to Defense Threat Reduction Agency Request for Information 2ImmuneRegen Responds to Defense Threat Reduction Agency Request for Information 3
... Immunogen: Synthetic peptide derived from the ... mouse dog and orangutang occludin proteins. ... occludin protein. Reactivity: Human (positive ... with rat mouse dog and orangutang ...
...
... protein western blot (WtPAN) is ... specific protein expression in plant ... is included in each blot ... comparison between different western blots. ...
... Water is suitable for use ... by incubating with 0.1% diethylpyrocarbonate ... remove the DEPC.DNase/RNase-Free Distilled WaterDistilled ... in all molecular biology applications. ...
Biology Products: