Navigation Links
Breast cancer drug fights fungal disease
Date:2/10/2014

Tamoxifen, a drug currently used to treat breast cancer, also kills a fungus that causes a deadly brain infection in immunocompromised patients. The findings, which could lead to new treatments for a disease that kills more HIV/AIDS patients than tuberculosis, appear in mBio, the online open-access journal of the American Society for Microbiology (ASM.)

"This work sets the stage for additional animal studies to see if tamoxifen can be used as a drug in people and will allow us to design new drugs related to tamoxifen that are better antifungals," says Damian Krysan of the University of Rochester, an author on the study.

Cryptococcosis is one of the most prevalent human fungal infections, responsible for approximately 1 million new infections and 620,000 deaths worldwide each year. The disease strikes primarily people living with HIV/AIDS and causes more deaths in this population than tuberculosis. It manifests as either pneumonia or a brain infection known as meningoencephalitis.

"The gold standard therapy for this infection is a combination of amphotericin B and 5-flucytosine. These drugs were first used in the late 1950s when penicillin was the antibiotic of choice. There have been no substantial improvements in the treatment of this disease in a half-century and the therapy is not available in many regions of the world that need it most," says Krysan.

In areas of the world where the gold-standard therapy is not available, like sub-Saharan Africa, the drug of choice is fluconazole because it is widely available and inexpensive. Unfortunately, it is much less effective since it does not actually kill the fungus.

"Recently, interest in re-using old drugs to treat new diseases has increased as a way to develop new therapies more quickly. We screened a large collection of old drugs for drugs that kill Cryptococcus and rediscovered tamoxifen," says Krysan. "We used clinical microbiology tests t
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Protein jailbreak helps breast cancer cells live
2. Breast cancer risk gene discovery fast tracked by new technology
3. A new breast cancer susceptibility gene
4. Mechanism found connecting metastatic breast cancer and arthritis
5. Detecting breast cancers fingerprint in a droplet of blood
6. Researchers identified a protein useful in predicting the risk of pulmonary metastases in breast cancer patients
7. High levels of TRAIL protein in breast milk might contribute to anticancer activity
8. Fourth IMPAKT Breast Cancer Conference
9. Breast cancer in young women: A distinct disease
10. Immune-response genes affecting breast tumor eradication
11. New data improve understanding of breast cancers multiple varieties
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... generally considered to be a disorder of brain development ... environmental, with other neurodevelopmental disorders such as autism and ... is determined by the combined effects of a complex ... factors. , However, longitudinal brain imaging studies in both ... map the disturbances in brain structures as they emerge, ...
(Date:9/15/2014)... the balance between ridding the body of a dangerous ... report appearing in The Journal of Experimental ... cause chronic infections in roughly three-quarters of infected people, ... including cirrhosis and cancer. A few patients successfully eliminate ... + T cells. The protective effects of CD8 ...
(Date:9/15/2014)... German . ... energy carrier natural gas offers a variety of options ... consequent market penetration is still pending because of a ... the Helmholtz Centre for Environ-mental Research (UFZ) and the ... the IEA Task 37 (Energy from Biogas) and the ...
Breaking Biology News(10 mins):Brain Development in Schizophrenia Strays from the Normal Path 2The biomethane market needs clear frame conditions for further growth 2The biomethane market needs clear frame conditions for further growth 3
... The Pollution Prevention Institute at Kansas State University is ... National Pollution Prevention Roundtable. The K-State institute,s intern ... Prevention Program award, also called the MVP2 award, as ... presented Tuesday, Sept. 22, in Washington, D.C. The ...
... - NiKem Research is pleased to announce that ... certification of its bioanalysis facilities to further extend its drug ... years high quality cost-effective bioanalytical support both for its ... PK services associated to various drug discovery programs and as ...
... new study shows that parents are more likely to understand ... a traffic light, than the standard charts currently in use. ... to parent could lead to parents earlier awareness of their ... lifestyle changes," says Eliana Perrin, M.D., M.P.H., senior and corresponding ...
Cached Biology News:K-State Pollution Prevention Institute's intern program named best 2NiKem Research receives certification for GLP Bioanalysis 2UNC study: Color-coded chart improves parents' understanding of body mass index 2
(Date:9/16/2014)... Norris, TN (PRWEB) September 16, 2014 ... several new initiatives to position themselves for ... capabilities for labeling and encoding, Pharma Packaging ... adding new hardware and software and new ... on current Good Manufacturing Practices (cGMP), Pharma ...
(Date:9/16/2014)... Oro Valley, Arizona (PRWEB) September 16, 2014 ... company that develops safe and effective products to ... through the use of a proprietary SPACEā„¢ Technology ... Executive Officer and President will present at the ... 18, 2014 at the Hyatt Regency Phoenix. ...
(Date:9/16/2014)... , Sept. 16, 2014  LABSCO, the ... and products to hospitals, physician office laboratories and ... effective October 1, 2014, it will serve as ... hospital market segments and as a semi-exclusive sales ... 48 contiguous United States . ...
(Date:9/16/2014)... 16, 2014 /PRNewswire-iReach/ -- Researchers found that ActiveLife ... patients with bone fragility fracture when today,s standard ... worldwide are at risk of fracture for reasons ... strength test, the DEXA bone density scan.  Study ... Bone and Mineral Research Annual Conference (ASBMR) in ...
Breaking Biology Technology:Adding Serialization Capabilities and Expanded Capacity, Pharma Packaging Solutions Is Preparing for 89th Year of Business 2Convoy Therapeutics to Present at WhiteHat Investor Conference September 18, 2014 2Convoy Therapeutics to Present at WhiteHat Investor Conference September 18, 2014 3LABSCO Secures Alliance With Siemens Healthcare Diagnostics 2LABSCO Secures Alliance With Siemens Healthcare Diagnostics 3ActiveLife's BMSi Test Provides Hope for 160 Million with Undetectable Risk of Bone Fracture 2ActiveLife's BMSi Test Provides Hope for 160 Million with Undetectable Risk of Bone Fracture 3
... Barr,Pharmaceuticals, Inc. (NYSE: BRL ) today ... approval from the U.S. Food & Drug,Administration (FDA) ... version of Forest Pharmaceuticals, Inc.,s Combunox(R) (oxycodone,HCl and ... of the New Combination exclusivity period for Combunox. ...
... N.C., Nov. 29 Kent Riddle, Director,Product Development, for ... to head development initiatives within the Medical,Biodevice Sector. The ... the growth of bioscience in North Carolina., "I ... part of this important,group," says Riddle. "DPI is at ...
... The Center for Molecular,Medicine (CMM) today announced ... Xceed,Molecular (http://www.xceedmolecular.com ; Wellesley, MA) collaborator program., ... US site to offer Xceed Molecular,s new,Ziplex(R) system ... tool in disease investigation and drug discovery. Analysis ...
Cached Biology Technology:Barr Receives Approval for Generic Combunox(R) Tablets, 5mg/400mg 2Barr Receives Approval for Generic Combunox(R) Tablets, 5mg/400mg 3Center for Molecular Medicine Offers Xceed Ziplex(TM) Services to Research Community 2
... power of your ValveBank system! Program ... a Macintosh computer using graphic 'click-and-drag' timebars. ... print out program listings, then download your ... simple step., EasyCode is used for programming ...
...
... The Jouan MSC series of ... comfortable working conditions and certification to ... automatic regulation ensures that the cabinets ... working conditions. Natural lighting, low noise ...
... HB-1000 Hybridizer hybridization ovens are designed to create ... Temperature control (ambient to 99.9C) , ... consistent saturation of samples, whether it be for ... which displays the current temperature inside the chamber, ...
Biology Products: