Navigation Links
Breast cancer cells have to learn to walk before they can run
Date:12/31/2007

La Jolla, CA Early-stage breast cancer that has not yet invaded the surrounding tissues may already contain highly motile cells, bringing the tumor one step closer to metastasis, report researchers at the Salk Institute for Biological Studies.

Their study, published in the Dec. 30 issue of the Journal of Cell Biology, suggests that these cells, although not yet invasive, could wander off along milk ducts and seed new tumors within the same breast. A lack of invasion suggested a lack of motility, says lead author Gray Pearson, Ph.D, a postdoctoral researcher in the Molecular and Cell Biology Laboratory at the Salk, but thats not so.

This is an exciting finding because it suggests that cells might acquire migratory properties much earlier than expected, says senior author Tony Hunter, Ph.D., a professor in the Molecular and Cell Biology Laboratory.

Due to improved screening programs, most breast tumors are discovered at an early stage when they are still small and confined. In such cases, cancer cells have not grown into the surrounding tissues and remain within the borders of a duct, the most common site where invasive breast cancer arises. These tumors are known as DCIS (ductal carcinoma in situ).

The standard treatment for DCIS is lumpectomy, the surgical removal of the tumor and surrounding tissue. Approximately 16% of DCIS patients treated with lumpectomy alone develop recurrent breast cancer growth within 5 years of treatment. One of the questions faced by oncologists and patients is whether they should add gamma radiation after undergoing surgery to catch straying tumor cells and reduce the risk of recurrent breast cancer. Currently, the decision is based solely on the size of the tumor.

Our findings suggest that, if a DCIS contains these highly motile cells, the patient may have an increased risk for recurrent growth, says Pearson. Under these circumstances you would consider adding radiation treatment re
'/>"/>

Contact: Gina Kirchweger
kirchweger@salk.edu
858-453-4100 x1340
Salk Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Newly created cancer stem cells could aid breast cancer research
2. Linchpin gene may be useful target for new breast cancer therapies
3. Dietary calcium could possibly prevent the spread of breast cancer to bone
4. Researchers find new gene linked to breast cancer
5. Analysis of breast and colon cancer genes finds many areas of differences between tumors
6. Genome update defines landscape of breast and colon cancers
7. AACR, BCRF award inaugural grants in translational breast cancer research
8. Enhanced DNA-repair mechanism can cause breast cancer
9. Einstein researchers receive grants totaling $700,000 for innovative breast cancer research
10. Breast cancer research and inkjet tissue printing get NSF boost
11. Breastfeeding boost IQ in infants with helpful genetic variant
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... NY, April 17, 2014The development of stem cell therapies ... ability to characterize stem cell populations based on cell ... discovered a new marker that is highly expressed in ... cord blood, which they describe in an article in ... Mary Ann Liebert, Inc., publishers. The article is available ...
(Date:4/17/2014)... anthrax detection cartridge developed at Sandia National Laboratories and ... easier, faster and cheaper. , Bacillus anthracis ... in soils all over the world and can cause ... animals. The bacteria can survive in harsh conditions for ... may occur through skin contact, inhalation of spores or ...
(Date:4/17/2014)... produce hydrogen sulfide in order to properly multiply and ... the Center for Craniofacial Molecular Biology at the Herman ... Shi, principal investigator on the project, said the presence ... flow of calcium ions. The essential ions activate a ... the creation of new bone tissue, and keeps the ...
Breaking Biology News(10 mins):Pocket-sized anthrax detector aids global agriculture 2Pocket-sized anthrax detector aids global agriculture 3
... Researchers have discovered how the protein Hap1, which is ... between circulating insulin in the blood and the neural ... of the neural pathway used by hormones to regulate ... targets for treating eating disorders and obesity. The ...
... The Walter and Eliza Hall Institute, using a mouse ... the formation of all breast tissue. This discovery lays ... develops. The identification of the breast stem cell is ... develops and how rogue cells evade current therapies. ...
... of an essential piece of the telomerase enzyme, an ... Understanding the physical shape of the protein has led ... immortalize cells ?and should help scientists design broadly effective ... structural information about the enzyme has hindered progress in ...
Cached Biology News:Hap1 protein links circulating insulin to brain circuits that regulate feeding behavior in mice 2Faults in newly discovered breast stem cells may lead to tumours 2Groovy protein essential for promoting cancer development 2Groovy protein essential for promoting cancer development 3Groovy protein essential for promoting cancer development 4
(Date:1/14/2014)... (PRWEB) January 14, 2014 In recent ... motives and methods in product development and promotion has ... industry. This mistrust, fueled by concerns about the insidious ... by reports of spectacular fines to the world’s biggest ...
(Date:1/14/2014)... January 14, 2014 Global Record ... innovative information technology solutions for patients, physicians, the ... stakeholders, announced today the signing of a three-year ... and Drug Administration (FDA). This initiative is ...
(Date:1/14/2014)... and Cardiff, UK (PRWEB) January 13, 2014 ... development leader with more than 20 years in the ... optics and photonics . Hainsey will serve as the ... to have Dr. Hainsey join SPIE as our Technology ...
(Date:1/14/2014)... Rochester, NY (PRWEB) January 14, 2014 During ... is now known as “The Doctor’s Plague.” In this time ... their hands. This led, at times, to the death of ... staff today don’t know that they may be unwittingly transmitting ...
Breaking Biology Technology:The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 3
... Corp.,(Nasdaq: GENZ ) announced today that it ... for the treatment of Hunter syndrome.,Elaprase is an ... Inc., and Genzyme is commercializing the product in ... with Shire. Genzyme intends,to launch Elaprase this quarter, ...
... Inc. (Nasdaq:,BIOD) today announced that Solomon Steiner, Chairman and CEO ... 2007 in San,Francisco, CA on October 11th at 11:00 AM ... live audio webcast of the,presentation in the investor relations section ... presentation will be available for,14 days. About Biodel Inc. ...
... new products, Skin Optimizer and Hyaluronic Acid Complex, promote ... skin and ... Formulas, recognized in,July by Nutrition Business Journal, selected BioCell Collagen ... the,effectiveness of two new Jarrow Formulas products -- Skin Optimizer ...
Cached Biology Technology:Genzyme Receives Approval to Market Elaprase(R) in Japan 2Genzyme Receives Approval to Market Elaprase(R) in Japan 3Genzyme Receives Approval to Market Elaprase(R) in Japan 4Biodel Inc. to Present at BIO InvestorForum 2007 Conference on October 11, 2007 2Jarrow Formulas Launches New Products Featuring BioCell Collagen II(R) 2
Amino-acids and Derivatives Rabbit Anti-conjugated L-isoleucine Polyclonal Antibody...
Anti-MMP-25 (Membrane-type MMP-6, Mt6MMP), hinge region; rabbit host...
Sheep polyclonal to Streptomycin ( Abpromise for all tested applications). Antigen: Chemical / Small Molecule: Streptomycin conjugated to BSA....
Mouse monoclonal [SPM217] to Secretory Component Glycoprotein ( Abpromise for all tested applications)....
Biology Products: