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Breakthrough technology focuses in on disease traits of single cells
Date:7/24/2012

ant is part of the NIH Common Fund project known as LINCS Library of Integrated Network-Based Cellular Signatures, which is a library of molecular signatures describing cell behavior in response to a variety of perturbing agents.

The central hypothesis of the LINCS project is that subjecting cells to perturbation can cause changes in the behavior and/or function that result in changes in the observable physical or biochemical characteristics of a cell or cell phenotype. Observing phenotypic cell changes in response to perturbation will help scientists better understand how environmental stresses on cells can cause them to transition to disease states.

While LINCS centers at Harvard Medical School and the Broad Institute are actively gathering molecular information, Meldrum stresses that the Cellarium's keen analytical capability to record dynamic characteristics of individual live cells in real time will provide a unique data set not attainable by any existing method. "We will be adding the dimensions of single-cell physiology and time to the LINCS database," Meldrum says.

The Cellarium array chip permits the study of individual cells in a high throughput format, providing measurement of critical parameters of cell metabolism including oxygen consumption, pH, adenosine triphosphate (ATP), and glucose. Studying the manner in which these and other single-cell variables change with time will help researchers gain insight into life and death processes of cells, such as neoplastic progression (e.g. cancer), and pyroptosis or proinflammatory cell deathimplicated in a range of inflammatory diseases as well as heart disease, stroke and cancer.

Meldrum's team received $669, 794 in funding to support the Cellarium project's inaugural year and the current award provides additional funding through August 2013. Over the next 18 months, the team will develop a disposable Cellarium microarray; employ a commercial microarray scanner to read c
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Contact: Joseph Caspermeyer
Joseph.Caspermeyer@asu.edu
Arizona State University
Source:Eurekalert  

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