Navigation Links
Breakthrough reveals blood vessel cells are key to growing unlimited amounts of adult stem cells
Date:3/4/2010

cular niche" can self-renew adult hematopoietic stem cells for weeks, both in vitro and in vivo, by co-culturing them on a bed of endothelial cells. The researchers chose endothelial cells because they are in close contact with blood stem cells, and previous work from Dr. Rafii's lab had demonstrated that endothelial cells produce novel stem-cell-active growth factors. However, maintenance of the endothelial cells is cumbersome and if they are not "fed" specific substances, such as growth factors known as "angiogenic factors," they immediately die. To get around this problem, the researchers genetically engineered the endothelial cells to stay in a long-term survival state by inserting a recently discovered gene cloned from adenoviruses, which does not promote oncogenic transformation of the human cells. This earlier discovery, using a single gene to put endothelial cells into a long-lasting "suspended animation" state without harming their ability to produce blood vessels, was also discovered in Dr. Rafii's lab and published in the journal Proceedings of National Academy Sciences in 2008.

Endothelial Cells Could Generate Stem Cells and Their Differentiated Progeny

In this study, the researchers also discovered that endothelial cells not only could expand stem cells, but also instruct stem cells to generate mature differentiated progeny that could form immune cells, platelets, and red and white blood cells, all of which constitute functioning blood.

"We are the first group to demonstrate that endothelial cells elaborate a repertoire of stem-cell-active growth factors that not only stimulate stem cell expansion but also orchestrate differentiation of these stem cells into their mature progeny," says Dr. Jason Butler, a senior investigator at Weill Cornell Medical College and first author of the study. "For example, we have found that expression of specific stem-cell-active factors, namely Notch-ligands, by the endothelial cells lini
'/>"/>

Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3 4 5 6

Related biology news :

1. Successful genome sequencing of pea aphid is a breakthrough for ecology and agricultural research
2. Understanding global climate change through new breakthroughs in polar research
3. The Full Yield, Inc. Launches Breakthrough Collaboration to Put Food Back at the Heart of Healthcare
4. Research breakthrough could lead to new treatment for malaria
5. Walkerton Tragedy: 10 years of research leads to breakthrough
6. TGen-Scottsdale Healthcare researchers make breakthrough in lung cancer
7. Scientists breakthrough in production of biofuels
8. A global breakthrough in the study of a protein linked to the spread of viruses
9. UC Riverside plant scientists research ranked on top ten breakthrough list for 2009
10. Major breakthrough may pave the way for therapeutic vaccines
11. Breakthrough in monitoring tropical deforestation announced in Copenhagen
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)... , Nov. 17, 2014   ... and EMC collaborate to develop The Partners Data ... , The Partners Data Lake will allow researcher ... improve diagnostics, treatment and the lives of patients ... research and clinical activities across the Partners system, ...
(Date:11/11/2014)... CHICAGO , Nov. 11, 2014  Forensicon, Inc., ... eDiscovery firm, is pleased to announce the promotion of ... to Director of Digital Forensics. In Schiff,s new role ... out the team of digital forensics examiners and provide ... Photo - http://photos.prnewswire.com/prnh/20141110/157719 ...
(Date:11/6/2014)... from a team of Florida State University biologists could ... adapt to and survive environmental swings such as droughts ... issue of the journal The Plant Cell , ... and proteins) is organized in a cell and how ... turned on and others are turned off. , "If ...
Breaking Biology News(10 mins):Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2Maize analysis yields whole new world of genetic science 2
... Novel use of genetic testing methods helped public health ... outbreaks of foodborne hepatitis A virus in 2003 related ... detailed analysis published in the October 15 issue of ... The authors of the study, Joseph J. Amon, PhD, ...
... methods helped public health officials control and limit the ... virus in 2003 related to the consumption of green ... October 15 issue of The Journal of Infectious Diseases, ... Joseph J. Amon, PhD, MSPH, and colleagues at the ...
... drug of choice for long-distance truckers and college students ... fruit flies, too. This finding is one of several ... for the neurotransmitter dopamine in the modulation of sleep, ... by Dr. Ralph Greenspan and colleagues at The Neurosciences ...
Cached Biology News:Disrupting Cocaine-memories To Battle Addiction 2Large-scale Computer Simulations Reveal New Insights Into Antibiotic Resistance 2
(Date:11/24/2014)... DUBAI , UAE, November 24, 2014 ... prestigious "Sheikh Hamdan Bin Rashid Al Maktoum Awards for ... in Dubai, United Arab Emirates , ... http://photos.prnewswire.com/prnh/20141124/717861 ) , The Carter Center ... Medical Services is actively involved in numerous programs that ...
(Date:11/24/2014)... NAMUR , Belgium , Nov. 24, ... life sciences company focused on developing diagnostic tests for cancer ... lung cancer study will be presented at the Science for ... Louvain-la-Neuve, Belgium . The data come from ... collected at the Pneumology department of the Centre Hospitalier Universitaire ...
(Date:11/24/2014)... Calif. , Nov. 24, 2014   Veracyte, Inc. ... Bonnie H. Anderson , president and chief executive officer, will ... 26 th Annual Healthcare Conference on Tuesday, December 2, ... . The live audio webcast and subsequent ... http://investor.veracyte.com . Please connect to the website at least 15 ...
(Date:11/24/2014)... MD (PRWEB) November 24, 2014 ... underrepresented patient populations into clinical trials at its ... , “Continental was created with the idea ... play a fundamental role in medical advances," said ... Tuskegee syphilis experiment to the immortal cell line ...
Breaking Biology Technology:Five US Winners Among Recipients of Hamdan Medical Awards 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 3VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 4VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 5VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 6Veracyte to Present at the Piper Jaffray 26th Annual Healthcare Conference 2At Continental Clinical Solutions, CEO Saleh Stevens Focuses on Diversity in Clinical Trial Recruitment at Maryland Site 2At Continental Clinical Solutions, CEO Saleh Stevens Focuses on Diversity in Clinical Trial Recruitment at Maryland Site 3
... BIO attendees , , Editors note : ... current Secretary of Health and Human Services Tommy Thompson, ... BIO 2004 Conference, talking place this week in San ... mayor, Gavin Newsom, pitched the crowd to not forget ...
... take to make a payroll and personnel tracker specifically for ... taken its tracking systems, originally generic, and made them into ... in Georgia. WellStar plans to use the application to manage ... unusual challenges. , ,"Our initial HR system was not health ...
... has introduced two new AV-ready Mediasite products designed ... variety of uses. The new products, evolved from ... intended to enable customers to record and distribute ... education, online training, product marketing and other related ...
Cached Biology Technology:WTN Interview: HHS Secretary calls for $550 million health care fund to reduce deaths caused by medical errors 2WTN Interview: HHS Secretary calls for $550 million health care fund to reduce deaths caused by medical errors 3Sonic Foundry announces new Mediasite products 2
Porcine TNF-alpha/TNFSF1A ELISpot Development Module...
5-bromo-4-chloro-3-indolyl b -D-galactopyranoside (X-Gal)...
... Attoglow Western Blot Analysis Kit ... analysis kit developed by Biochain. It ... g) or yoctomole (10 -24 ... of three parts: Millennium Enhancer, protein ...
... BioNumerics is the universal bioinformatics software that ... data. The unique modular design of BioNumerics ... virtually any type of data employed for ... microarrays, DNA fingerprints, 2-D protein gels, HPLC, ...
Biology Products: