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Breakthrough research turns the tide on water-borne pathogen
Date:1/25/2008

Waltham, MACryptosporidium parvum is a tiny yet insidious waterborne parasite that wreaks havoc worldwide. This parasite is a major cause of diarrhea and malnutrition in small children in developing countries, and causes severe disease in AIDS and other immune compromised patients in the developed world. Cryptosporidium is resistant to water chlorination and has caused massive outbreaks in the U.S., which has led to the concern that the parasite could be used as a bio-terrorism agent. There are neither vaccines nor effective drugs available to respond to these multiple threats to human health.

In this weeks issue of Chemistry and Biology, researchers at Brandeis University and the University of Georgia report they have identified lead compounds that inhibit Cryptosporidiums parasitic punch, paving the way for an effective antibiotic treatment. In all, scientists identified ten new compounds, four of which are better at fighting Cryptosporidium than the antibiotic paromomycin, the current gold standard for evaluating anticryptosporidial activity.

These are promising new compounds and this research provides an avenue of much needed therapy for this disease, said Brandeis biochemist Lizbeth Hedstrom, whose lab identified the compounds together with parasitologist Boris Striepen of the University of Georgia.

While there are many drugs to treat bacterial infections, it has been very difficult to find drugs against pathogens like Cryptosporidium because the proteins of these parasites are actually very similar to those of their human host. Scientists have been further thwarted because little was known about Cryptosporidium metabolism. This situation recently changed dramatically when genome sequencing provided a genetic blueprint of Cryptosporidium.

In work leading up to the current study, Hedstrom and Striepen used this blueprint to show that Cryptosporidium has a very simple process to produce the building blocks of DNA and RNA
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Contact: Laura Gardner
gardner@brandeis.edu
781-736-4204
Brandeis University
Source:Eurekalert

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