Navigation Links
Breakthrough on cystic fibrosis 1 step closer as new research alliance formed
Date:1/27/2011

McGill University and GlaxoSmithKline plc (GSK) have signed a collaboration agreement to develop a potential breakthrough approach to treat cystic fibrosis, a fatal genetic disease. The trans-Atlantic effort between researchers from McGill's Faculty of Medicine and their GSK collaborators in the UK, will focus on developing molecules that could treat the disease by correcting the dysfunction caused by the mutated gene. This revolutionary approach will be a departure from current treatments, which only manage the symptoms or complications of the disorder. The collaborative research is co-sponsored by the Canadian Institutes of Health Research (CIHR).

Cystic fibrosis (CF) is one of the most common fatal genetic diseases. It is a multi-organ disease but primarily affects the lungs and digestive system, causing mucous to thicken and leaving patients at higher risk of infections. CF is caused by a mutation in the gene for the protein cystic fibrosis transmembrane conductance regulator (CFTR). About 90 per cent of those living with cystic fibrosis have a particular mutant form of this gene, which makes a protein that could still work but has a defect that prevents it getting to the right place in the cell to function correctly.

Dr. David Thomas, Chair of McGill's Department of Biochemistry and Canada Research Chair in Molecular Genetics, is an expert in protein quality control. Dr. John Hanrahan is Professor in McGill's Department of Physiology and an expert in chloride transport and epithelial biology. They are uniquely qualified as lead investigators on McGill's side, having conducted extensive research on the CFTR protein and have identified a number of molecules that look to restore normal CFTR function.

"If we can restore normal function to the mutant cystic fibrosis protein, we can radically transform the lives of millions of children. It will move us from treatment of symptoms to prevention of the disease and would ultimately save
'/>"/>

Contact: Allison Flynn
allison.j.flynn@mcgill.ca
514-398-7698
McGill University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Biomedical breakthrough: Blood vessels for lab-grown tissues
2. 7 CAMH scientists win Young Investigator awards focused on breakthrough research
3. Shellfish safer to eat thanks to breakthrough by Queens scientists
4. IVF breakthrough to hit the world market
5. An important breakthrough by IRCM researchers in hematopoiesis and the development of B cells
6. Damon Runyon Cancer Research Foundation awards breakthrough scientists
7. Breakthrough in worm research has implications for human disease studies
8. VCU Massey discovery could lead to breakthrough for non-small cell lung cancer
9. Longevity breakthrough: The metabolic state of mitochondria controls life span
10. Argonne scientists awarded supercomputing time to enable scientific breakthroughs
11. $1.6 million to take forward breakthrough research in heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... What do seedless watermelon, salmon, and strawberries all have ... have two sets of chromosomes and are diploid, these ... more sets of chromosomesseedless watermelon and salmon have 3 ... 10! While this might seem surprising, in fact ... was first discovered over a century ago, but only ...
(Date:9/30/2014)... Calif. The National Institutes of Health (NIH) ... today to develop an electrode array system that ... brain works through unprecedented resolution and scale. , ... to support President Obama,s BRAIN (Brain Research ... research effort to revolutionize our understanding of the ...
(Date:9/30/2014)... scientists and engineers, led by Clemson University associate ... million grant from the U.S. Department of Energy,s ... a direct positive impact on South Carolina in ... radioactive contaminants. , "Understanding the scientific and engineering ... aspects of nuclear technologies is imperative if South ...
Breaking Biology News(10 mins):Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 2Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 3Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 4NIH taps lab to develop sophisticated electrode array system to monitor brain act 2NIH taps lab to develop sophisticated electrode array system to monitor brain act 3Researchers get $5.25 million to advance nuclear technologies in South Carolina 2
... cell biologists there are few better-known proteins than nestin, whose ... "stem cell," such as a neural stem cell. As helpful ... which purpose nestin serves in a cell. In a ... of Nature Neuroscience , Salk Institute of Biological Studies ...
... of California, San Diego School of Medicine provides ... defects associated with a rare childhood neurological disease ... be defective in LND are known to be ... and Parknson,s diseases, suggesting common causes of cognitive ...
... ARBOR, Mich.---DNA, that marvelous, twisty molecule of life, has an ... University of California, Irvine reveals. On rare occasions, its ... into a different shape. "We show that the simple ... of the time---and that this alternative form is functional," said ...
Cached Biology News:Salk researchers discover that stem cell marker regulates synapse formation 2Salk researchers discover that stem cell marker regulates synapse formation 3Genetic clues to compulsive, self-injurious behavior in rare childhood disorder 2Genetic clues to compulsive, self-injurious behavior in rare childhood disorder 3DNA caught rock 'n rollin' 2
(Date:9/30/2014)... Nematicide is a type of chemical ... parasitic roundworms, found in massive quantities virtually everywhere—in ... animals. Nematicides have tended to be broad-spectrum toxicants ... through the soil. A single gram of soil ... more than 10,000 species classified, they are one ...
(Date:9/30/2014)... 2014 Follow us on LinkedIn ... type of cholesterol carrier or lipoprotein in the blood. ... cholesterol levels in the body, especially along the walls ... attack and other cardiovascular disorders. Cardiovascular Diseases (CVD) is ... cholesterol levels on a regular basis, to assess an ...
(Date:9/30/2014)... Fast, semi-automatic creation of ... documents ChemAxon , a leader ... for life science research, launches ChemCurator, an application ... from documents. Markush structures are essential ... and understanding Markush structures is a difficult and ...
(Date:9/30/2014)... CORALVILLE, Iowa , Sept. 30, 2014 /PRNewswire/ ... in the discovery and development of proprietary new ... United States Patent and Trademark Office (USPTO) issued ... patent application entitled, "Benzoic Acid, Benzoic Acid Derivatives ... Methods of Making and Use Thereof." ...
Breaking Biology Technology:Nematicides Market by Types (Fumigants, Organophosphates, Carbamate and Bio-Nematicides), Applications (Agrochemicals, Industrial, and Others), and Geography (North America, Europe, Asia-Pacific & ROW) - Global Trends & Forecasts to 2019 2Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 2Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 3Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 4ChemAxon Introduces ChemCurator for Chemical Information Extraction and Markush Structure Creation 2KemPharm, Inc. Receives Patent from the USPTO for Novel Prodrug of Hydromorphone, KP511 2
... Corn Growers Association reminds U.S. Bt corn growers that the development of ... their planning process. , ... St. Louis, MO (PRWEB) February 20, ... Association (NCGA) reminds U.S. Bt corn growers that the development of ...
... Feb. 20 Mach One Corporation (Pink Sheets: MNCN), ... for positive, long term benefit to the agricultural and ... the acquisition of Modular Process Constructors LLC (MPC).Mach One ... $500,000 of Series B convertible preferred stock at a ...
... February 20 Authentic Natural and Organic,Cosmetic* products ... the NaTrue,Label: the first 100 products have already ... The NaTrue-Label provides orientation for ... criteria for Natural and Organic,Cosmetics. It is international, ...
Cached Biology Technology:Corn Growers Reminded to Follow Refuge Requirements as Spring Planting Nears 2Corn Growers Reminded to Follow Refuge Requirements as Spring Planting Nears 3Mach One Closes on Acquisition of Biopharmaceutical Design & Engineering Firm 2NaTrue-Label: The First 100 Products are Certified 2
...
...
... and supplies, for 10 chips, provides ... perform standard-sensitivity RNA analysis (nanogram levels) ... automated electrophoresis system. Supplied are 1,250 ... StdSens stain, 20 microliters RNA ladder, ...
... vectors are designed for enhanced translation of cloned ... rabbit reticulocyte lysate. The maps for pCITE-2b(+) and ... following exceptions: pCITE-2b(+) is a 3793 bp plasmid; ... and Xcm I sites. Subtract 7 bp from ...
Biology Products: