Navigation Links
Breakthrough in worm research has implications for human disease studies
Date:12/17/2010

RENO, Nev. It's just a worm, a tiny soil-dwelling nematode worm but the implications are big for biomedicine and circadian biology as shown in a recent study authored by University of Nevada, Reno researcher Alexander van der Linden. The article on the circadian clock of the Caenorhabditis elegans worm was published in the peer-reviewed, open-access journal, PLoS Biology.

"Circadian rhythms are important in all organisms because they regulate biological functions such as food intake, temperature, metabolic rate and sleep," van der Linden said. "The discovery of clock-controlled genes in C. elegans should lead to an expanded research role in worms, and give a better understanding of the mammalian circadian clock.

For more than two decades, researchers have wondered whether C. elegans, one of the foremost research model organisms, contains a circadian clock. Circadian rhythmic behaviors described previously in C. elegans are variable and hard to quantify, and no genes were known to exhibit gene expression oscillations with 24-hour cycles as shown in many other animals.

Now, a team of researchers led by professors of biology Piali Sengupta and Michael Rosbash at Brandeis University, Waltham, and lead author van der Linden, who is a former postdoctoral fellow in the Sengupta Lab and now assistant professor in the College of Science at the University of Nevada, Reno, has uncovered genes in C. elegans under clock control from both light and temperature.

"C. elegans offers several advantages to study the function of human disease genes through their corresponding worm genes," he said. "We now not only have a new model to study the function of this important biological clock, but we can also study how the clock evolved over time, since nematodes and humans diverged about 600 to 1,200 million years ago."

Almost every organism on earth exhibits circadian rhythms periodic cy
'/>"/>

Contact: Mike Wolterbeek
mwolterbeek@unr.edu
University of Nevada, Reno
Source:Eurekalert

Page: 1 2

Related biology news :

1. VCU Massey discovery could lead to breakthrough for non-small cell lung cancer
2. Longevity breakthrough: The metabolic state of mitochondria controls life span
3. Argonne scientists awarded supercomputing time to enable scientific breakthroughs
4. $1.6 million to take forward breakthrough research in heart disease
5. Medical imaging breakthrough uses light and sound to see microscopic details inside our bodies
6. A recent IRCM breakthrough impacts cancer research
7. Breakthrough: With a chaperone, copper breaks through
8. Research breakthrough hailed on the anniversary of gene discovery
9. A scientific breakthrough could be the first step in a better treatment for leukemia patients
10. Microbial breakthrough impacts health, agriculture, biofuels
11. Carbon mapping breakthrough
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... years, man has domesticated animals, selecting the best ... sheep offer an intriguing animal to examine adaptation ... centuries of selected breeding and a wealth of ... first-of-its kind study that combined molecular and environmental ... search for genes under environmental selection from domesticated ...
(Date:9/23/2014)... oil sands tailings has just gotten a lot greener ... Alberta civil engineering professors that uses solar energy to ... of using UV lamps as a light source to ... tailings ponds, professors Mohamed Gamal El-Din and James Bolton ... energy source treats the wastewater just as efficiently but ...
(Date:9/23/2014)... A multidisciplinary team at the University of Wisconsin-Madison and ... more affordable way to screen for neural toxins, helping ... National Institutes of Health (NIH) announced today that the ... support to continue the promising work as part of ... will receive approximately $7 million over the three-year project. ...
Breaking Biology News(10 mins):Being sheepish about climate adaptation 2Solar energy-driven process could revolutionize oil sands tailings reclamation 2UW-Madison team developing 'tissue chip' to screen neurological toxins 2UW-Madison team developing 'tissue chip' to screen neurological toxins 3
... (OSCC) is responsible for nearly a quarter of all head ... of cancer death - largely due to the failure of ... New research published in BioMed Central,s open access journal ... predict which patients are at higher risk of OSCC recurrence. ...
... at the University of York and Hull York Medical ... the brain is affected by age. Working with ... in Plymouth, they have studied responses to stress in ... that under stressful conditions, such as neuro-degeneration, resulting high ...
... a key role in turning off disease? Researchers ... a biosensor they,ve created that measures membrane lipid levels may ... distinguished professor of chemistry, and his coworkers engineered a way ... lipid levels. Their findings are reported in Nature ...
Cached Biology News:Researchers study aging's effect on the brain 2New membrane lipid measuring technique may help fight disease 2
(Date:9/23/2014)... from the University of Southampton,s Optoelectronics Research Centre ... a potential challenger to graphene. , Graphene, a ... lattice, is increasingly being used in new electronic ... light sources, thanks to the unprecedented properties it ... and mechanically stretchable yet harder than diamond. , ...
(Date:9/23/2014)... France (PRWEB) September 23, 2014 ... of laboratory personnel since 1968 and Burdinola, supplier of ... of a new filtered fume hood. , ... laboratory fume hood, Burdinola will now offer an innovative ... a wide range of chemicals, best-in-class detection technology, and ...
(Date:9/23/2014)... IRVINE, CA and ANNAPOLIS JUNCTION, MD (PRWEB) September 23, ... commercial and research leader in personalized medicine, presented industry ... and opioid misuse this past weekend at the ... Clinical Meeting. The meeting took place in Phoenix, Arizona ... their proprietary study on the linkage between gender and ...
(Date:9/23/2014)... 23, 2014 /PRNewswire/ - Portage Biotech Inc. ("Portage" or ... is pleased to announce that its wholly owned ... more  consultants to its team for further development ... new proprietary cell permeable peptide platform technology derived ... into the eye. Ms. ...
Breaking Biology Technology:Southampton scientists grow a new challenger to graphene 2Erlab Partners with Burdinola to Deliver an Innovative Filtered Fume Hood 2Proove Biosciences Will Be Exhibiting I.M.P.L.O.R.E Study at the American Academy of Pain Management 25th Annual Meeting 2Proove Biosciences Will Be Exhibiting I.M.P.L.O.R.E Study at the American Academy of Pain Management 25th Annual Meeting 3Portage Announces New Consultants for its PPL-003 Development Programs 2Portage Announces New Consultants for its PPL-003 Development Programs 3Portage Announces New Consultants for its PPL-003 Development Programs 4
... - With Sony set to take over Sonic Foundrys desktop ... go from here? Two words: Mediasite Live. , ,Sonic ... audio conferencing market by enhancing web conferencing with Mediasite Live. ... great opportunity for the company to go forward because there ...
... stream video from their Charleston and Morgantown campuses so students ... All of WVUs core graduate nursing school courses will be ... ,We need more nurses and we need more nurse educators ... professor of nursing at WVU School of Nursing. By using ...
... better drugs, faster part of the speech. Thats where the ... is likely to hit the road, especially as the largest ... become as common in conversation as golf games and grandkids. ... Vodenlich joined as president earlier this year, recently restructured its ...
Cached Biology Technology:Sonic Foundry: What's Next? 2Sonic Foundry Facilitates Nursing Education 2Sonic Foundry Facilitates Nursing Education 3Chipping Away at Drug Development 2Chipping Away at Drug Development 3
Puromycin resistance gene (pac), provided in a pORF plasmid. pORF is an expression plasmid selectable with Ampicillin....
Plasmid expressing Zeocin resistance gene....
...
... template is designed to allow kanamycin/neomycin ... It combines a prokaryotic promoter (gb2) ... E.coli with a eukaryotic promoter (PGK) ... cells. The prokaryotic promoter gb2 is ...
Biology Products: