Navigation Links
Breakthrough in worm research has implications for human disease studies
Date:12/17/2010

RENO, Nev. It's just a worm, a tiny soil-dwelling nematode worm but the implications are big for biomedicine and circadian biology as shown in a recent study authored by University of Nevada, Reno researcher Alexander van der Linden. The article on the circadian clock of the Caenorhabditis elegans worm was published in the peer-reviewed, open-access journal, PLoS Biology.

"Circadian rhythms are important in all organisms because they regulate biological functions such as food intake, temperature, metabolic rate and sleep," van der Linden said. "The discovery of clock-controlled genes in C. elegans should lead to an expanded research role in worms, and give a better understanding of the mammalian circadian clock.

For more than two decades, researchers have wondered whether C. elegans, one of the foremost research model organisms, contains a circadian clock. Circadian rhythmic behaviors described previously in C. elegans are variable and hard to quantify, and no genes were known to exhibit gene expression oscillations with 24-hour cycles as shown in many other animals.

Now, a team of researchers led by professors of biology Piali Sengupta and Michael Rosbash at Brandeis University, Waltham, and lead author van der Linden, who is a former postdoctoral fellow in the Sengupta Lab and now assistant professor in the College of Science at the University of Nevada, Reno, has uncovered genes in C. elegans under clock control from both light and temperature.

"C. elegans offers several advantages to study the function of human disease genes through their corresponding worm genes," he said. "We now not only have a new model to study the function of this important biological clock, but we can also study how the clock evolved over time, since nematodes and humans diverged about 600 to 1,200 million years ago."

Almost every organism on earth exhibits circadian rhythms periodic cycles of behavior or gene expression that repeat roughly every 24 hours. These rhythms are generated by a circadian clock an internal time-keeping mechanism which can be entrained and synchronized by environmental signals such as temperature or light/dark cycles.

"Given its small and well-mapped nervous system, combined with a wealth of available genetic and behavioral tools, C. elegans is a viable research organism in the circadian field," van der Linden said. "The next critical step will be to determine how these worm molecular rhythms relate to circdian behavioral rhythms."


'/>"/>

Contact: Mike Wolterbeek
mwolterbeek@unr.edu
University of Nevada, Reno
Source:Eurekalert

Related biology news :

1. VCU Massey discovery could lead to breakthrough for non-small cell lung cancer
2. Longevity breakthrough: The metabolic state of mitochondria controls life span
3. Argonne scientists awarded supercomputing time to enable scientific breakthroughs
4. $1.6 million to take forward breakthrough research in heart disease
5. Medical imaging breakthrough uses light and sound to see microscopic details inside our bodies
6. A recent IRCM breakthrough impacts cancer research
7. Breakthrough: With a chaperone, copper breaks through
8. Research breakthrough hailed on the anniversary of gene discovery
9. A scientific breakthrough could be the first step in a better treatment for leukemia patients
10. Microbial breakthrough impacts health, agriculture, biofuels
11. Carbon mapping breakthrough
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... 2016  The American College of Medical Genetics and Genomics ... as one of the fastest-growing trade shows during the ... Bellagio in Las Vegas . ... growth in each of the following categories: net square feet ... of attendees. The 2015 ACMG Annual Meeting was ranked 23 ...
(Date:6/21/2016)... VANCOUVER, British Columbia , June 21, 2016 ... been appointed to the new role of principal ... has been named the director of customer development. ... , NuData,s chief technical officer. The moves reflect ... development teams in response to high customer demand ...
(Date:6/15/2016)... York , June 15, 2016 ... new market report titled "Gesture Recognition Market by Application ... Forecast, 2016 - 2024". According to the report, the  ... 11.60 billion in 2015 and is estimated to ... USD 48.56 billion by 2024.  Increasing ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... , ... Supplyframe, the Industry Network for electronics hardware design ... Located in Pasadena, Calif., the Design Lab’s mission is to bring together inventors ... and brought to market. , The Design Lab is Supplyframe’s physical representation of ...
(Date:6/23/2016)... ... ... In a new case report published today in STEM CELLS Translational Medicine, ... after being treated for breast cancer benefitted from an injection of stem cells derived ... debilitating, frequent side effect of cancer treatment. , Lymphedema refers to the ...
(Date:6/23/2016)... NEWPORT BEACH, Calif. , June 23, 2016 /PRNewswire/ ... offering new biological discoveries to the medical community, has ... and co-founder Matthew Nunez . "We ... provide us with the capital we need to meet ... funding will essentially provide us the runway to complete ...
(Date:6/23/2016)... 23, 2016 On Wednesday, June 22, ... down 0.22%; the Dow Jones Industrial Average edged 0.27% lower ... 2,085.45, down 0.17%. Stock-Callers.com has initiated coverage on the following ... Therapeutics (NASDAQ: NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ... BIND ). Learn more about these stocks by accessing ...
Breaking Biology Technology: