Navigation Links
Breakthrough in regulating fat metabolism
Date:12/8/2011

Scientists at Warwick Medical School have made an important discovery about the mechanism controlling the body's 'fat switch', shedding new light on our understanding of how proteins regulate appetite control and insulin secretion.

This research, led by Professor Victor Zammit, Head of Metabolic and Vascular Health at Warwick Medical School, found that the enzyme known as 'Carnitine palmitoyltransferase 1A' (CPT1) has a switch which is thrown depending on the composition and curvature of its cellular membrane. This is the first time such a mechanism has been described and may possibly be unique, reflecting the importance of this protein to cellular function.

CPT1 is the key protein that regulates fatty acid oxidation in the liver and is critical for metabolism. Its activity determines whether individuals suffer from fatty liver in one extreme or ketosis in the other.

Professor Zammit explained: "Knowing that the CPT1 enzyme can switch and what controls it will ultimately lead to a better understanding of why some people appear to have a speedy metabolism and others struggle to curb their appetite.

"We are making great inroads to understanding the science behind our metabolism and how at cellular level it changes according to the influence of different factors be they nutritional or hormonal."

The importance of this work on clinical practice is that, having discovered the molecular mechanism, it should now be possible to design drugs that flick the switch of CPT1 in one way or the other, depending on the requirements of individual patients and the tissue that needs to be affected. For example, drugs can be developed for patients suffering from diabetic keto acidosis, a condition when insufficient insulin caused the body to start breaking down fat, so that the enzyme is inhibited to oxidize fewer fatty acids.

"This would be a major breakthrough in tackling the obesity crisis we now face," added Professor Zammit.
'/>"/>

Contact: Kate Cox
kate.cox@warwick.ac.uk
44-024-761-50483
University of Warwick
Source:Eurekalert

Page: 1

Related biology news :

1. Breakthrough in the production of flood-tolerant crops
2. Wayne State announces license agreement for breakthrough approaches to vision restoration
3. Southampton scientists herald significant breakthrough in study of chlamydia
4. Breakthrough: A robot brain implanted in a rodent
5. Scientists announce human intestinal stem cell breakthrough for regenerative medicine
6. Breakthrough in hydrogen fuel cells
7. Breakthrough lights way for RNA discoveries
8. Scientists breakthrough attracts new funding for high blood pressure research
9. AAPS national biotechnology conference to highlight breakthrough cancer treatments
10. Major breakthrough in preventing premature birth announced by NIH/WSU
11. From science fiction to research breakthrough
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/1/2017)... IDTechEx Research, a leading provider of independent market research, ... a new report, Sensors for Robotics: Technologies, Markets and Forecasts ... ... Revenues ... "Sensors for Robotics: Technologies, Markets and Forecasts 2017-2027: Machine vision, force ...
(Date:1/30/2017)...   Invitae Corporation (NYSE: NVTA ... today announced that it will report its fourth quarter ... on Monday, February 13, 2017, and Invitae,s management team ... p.m. Eastern / 1:45 p.m. Pacific. ... financial results, guidance, and recent developments and will spend ...
(Date:1/26/2017)...  Acuity Market Intelligence today released the 2017 ...  Acuity characterizes 2017 as a "breakout" year for ... a new understanding of the potential benefits these ... identity are often perceived as threats to privacy ... of Acuity Market intelligence. "However, taken together these ...
Breaking Biology News(10 mins):
(Date:2/23/2017)... NEW YORK , Feb. 23, ... , a leading digital health company, and ... of telemedicine and remote patient monitoring, announce they ... reimbursements.  DN Telehealth maximizes collaboration ... real-time, extending consultations beyond a physical clinical setting ...
(Date:2/23/2017)... 23, 2017  In Atlanta, it seems everyone has a ... intertwine to create an expressive and dynamic community unlike any ... and contribute to it. With their newest ... seeks to carry on that tradition with a unique, ... salon is the newest of 13 nationwide locations, ...
(Date:2/23/2017)... INDIANAPOLIS, Ind. (PRWEB) , ... February 23, 2017 ... ... Commercialization Award during the 12th annual Inventors Recognition Reception at Purdue Research ... annually to a faculty member in recognition of outstanding contributions to, and success ...
(Date:2/23/2017)... SAN DIEGO and SAN FRANCISCO ... , a privately-held regenerative medicine company, and Beyond Type ... living with type 1 diabetes, today announced a grant ... develop a functional cure for type 1 and other ... decade, ViaCyte has been developing innovative stem cell-derived cell ...
Breaking Biology Technology: