Navigation Links
Breakthrough in fight against Hendra virus
Date:10/30/2009

There has been a breakthrough in the fight against the deadly Hendra virus following the development of a treatment which shows great potential to save the lives of people who become infected with the virus.

A scientific team from CSIRO and the US has demonstrated that administering human monoclonal antibodies after exposure to Nipah virus, which is closely related to Hendra virus, protected animals from challenge in a disease model.

According to CSIRO's Dr Deborah Middleton, who led the experiments at Australia's maximum biosecurity facility, CSIRO's Australian Animal Health Laboratory (AAHL) in Geelong, said the findings are extremely encouraging.

"Our research clearly suggests that an effective treatment for Hendra virus infections in humans should be possible, given the very strong cross-reactive activity this antibody has against Hendra virus," she said.

Antibodies proteins found in blood or other bodily fluids of vertebrates are used by the immune system to identify and neutralise bacteria and viruses.

First identified in Brisbane and isolated by CSIRO scientists in 1994, Hendra virus, which spreads from flying foxes, has regularly infected horses in Australia. Of the 12 equine outbreaks, four have led to human infection, with four of the seven known human cases being fatal, the most recent of these in September 2009. Human infection results from close contact with the blood and/or mucus of infected horses.

Dr Middleton said the success of the antibody will probably depend on dose and time of administration.

"As Hendra and Nipah viruses cause severe disease in humans, a successful application of this antibody as a post-exposure therapy will likely require early intervention.

"To make clinical use of it against these viruses, it will need to be prepared under proper manufacturing guidelines, carefully evaluated again in animal models and safety tested for human use. We hope this demonstration of antiviral activity will lead to some immediate activities to facilitate further development for its use in humans," Dr Middleton said.


'/>"/>

Contact: Emma Wilkins
Emma.Wilkins@csiro.au
61-352-275-123
CSIRO Australia
Source:Eurekalert  

Related biology news :

1. Bio-optics breakthroughs: Highlights of medical and bioscience research at Frontiers in Optics 2009
2. Canadian research breakthrough holds promise for development of effective cancer therapies
3. Researchers achieve major breakthrough with water desalination system
4. Major breakthrough in early detection and prevention of AMD
5. Breakthrough made in assessing marine phytoplankton health
6. Breakthrough in radiotherapy promises targeted cancer treatment
7. Breakthrough in the treatment of bacterial meningitis
8. NEWSLETTER: Antibody Fragment Production Breakthrough with 2nd Generation EBA
9. Breakthrough made in energy efficiency, use of waste heat
10. Stem cell breakthrough: Monitoring the on switch that turns stem cells into muscle
11. Stem cell breakthrough gives new hope to sufferers of muscle-wasting diseases
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Breakthrough in fight against Hendra virus
(Date:4/13/2017)... April 13, 2017 According to a new market ... Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, ... Market is expected to grow from USD 14.30 Billion in 2017 to ... of 17.3%. ... MarketsandMarkets Logo ...
(Date:4/11/2017)... Research and Markets has announced the addition of the ... ... grow at a CAGR of 30.37% during the period 2017-2021. ... prepared based on an in-depth market analysis with inputs from industry ... over the coming years. The report also includes a discussion of ...
(Date:4/11/2017)... April 11, 2017 NXT-ID, Inc. (NASDAQ: ... company, announces the appointment of independent Directors Mr. Robin ... its Board of Directors, furthering the company,s corporate governance and ... Gino Pereira ... look forward to their guidance and benefiting from their considerable ...
Breaking Biology News(10 mins):
(Date:6/20/2017)... ... June 20, 2017 , ... National executive ... leader with extensive assay development and biomarker expertise, as VP of Scientific Affairs ... CRO specializing in bio-analytical assay development and sample testing services. The organization acts ...
(Date:6/20/2017)... , ... June 20, 2017 , ... ... discovery of antibody therapeutics from millions-diverse immune repertoires, announces launch of its new ... Diego, California. Dave Johnson, PhD, CEO of GigaGen, will present on Surge at ...
(Date:6/19/2017)... ... June 19, 2017 , ... ... development reported today that it is launching two new additions of its award-winning ... demonstrating new capabilities at the DIA 2017 Annual Meeting in Chicago, IL, June ...
(Date:6/19/2017)... ... 2017 , ... A colony of healthy honey bees is like a superorganism--individual ... and nectar containing nutrients necessary for growth and survival. Better nutrition gives the colony ... point to a decline in honey bee health. Sick and weakened bees diminish the ...
Breaking Biology Technology: