Navigation Links
Breakthrough in fight against Hendra virus
Date:10/30/2009

There has been a breakthrough in the fight against the deadly Hendra virus following the development of a treatment which shows great potential to save the lives of people who become infected with the virus.

A scientific team from CSIRO and the US has demonstrated that administering human monoclonal antibodies after exposure to Nipah virus, which is closely related to Hendra virus, protected animals from challenge in a disease model.

According to CSIRO's Dr Deborah Middleton, who led the experiments at Australia's maximum biosecurity facility, CSIRO's Australian Animal Health Laboratory (AAHL) in Geelong, said the findings are extremely encouraging.

"Our research clearly suggests that an effective treatment for Hendra virus infections in humans should be possible, given the very strong cross-reactive activity this antibody has against Hendra virus," she said.

Antibodies proteins found in blood or other bodily fluids of vertebrates are used by the immune system to identify and neutralise bacteria and viruses.

First identified in Brisbane and isolated by CSIRO scientists in 1994, Hendra virus, which spreads from flying foxes, has regularly infected horses in Australia. Of the 12 equine outbreaks, four have led to human infection, with four of the seven known human cases being fatal, the most recent of these in September 2009. Human infection results from close contact with the blood and/or mucus of infected horses.

Dr Middleton said the success of the antibody will probably depend on dose and time of administration.

"As Hendra and Nipah viruses cause severe disease in humans, a successful application of this antibody as a post-exposure therapy will likely require early intervention.

"To make clinical use of it against these viruses, it will need to be prepared under proper manufacturing guidelines, carefully evaluated again in animal models and safety tested for human use. We hope this demonstration of antiviral activity will lead to some immediate activities to facilitate further development for its use in humans," Dr Middleton said.


'/>"/>

Contact: Emma Wilkins
Emma.Wilkins@csiro.au
61-352-275-123
CSIRO Australia
Source:Eurekalert  

Related biology news :

1. Bio-optics breakthroughs: Highlights of medical and bioscience research at Frontiers in Optics 2009
2. Canadian research breakthrough holds promise for development of effective cancer therapies
3. Researchers achieve major breakthrough with water desalination system
4. Major breakthrough in early detection and prevention of AMD
5. Breakthrough made in assessing marine phytoplankton health
6. Breakthrough in radiotherapy promises targeted cancer treatment
7. Breakthrough in the treatment of bacterial meningitis
8. NEWSLETTER: Antibody Fragment Production Breakthrough with 2nd Generation EBA
9. Breakthrough made in energy efficiency, use of waste heat
10. Stem cell breakthrough: Monitoring the on switch that turns stem cells into muscle
11. Stem cell breakthrough gives new hope to sufferers of muscle-wasting diseases
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Breakthrough in fight against Hendra virus
(Date:4/6/2017)... 6, 2017 Forecasts by Product ... Readers, by End-Use (Transportation & Logistics, Government & Public ... & Fossil Generation Facility, Nuclear Power), Industrial, Retail, Business ... Are you looking for a definitive report on ... ...
(Date:4/4/2017)... , April 4, 2017   EyeLock LLC , ... that the United States Patent and Trademark Office (USPTO) ... covers the linking of an iris image with a ... and represents the company,s 45 th issued patent. ... is very timely given the multi-modal biometric capabilities that ...
(Date:3/30/2017)... March 30, 2017 Trends, opportunities and forecast ... behavioral), by technology (fingerprint, AFIS, iris recognition, facial recognition, ... others), by end use industry (government and law enforcement, ... and banking, and others), and by region ( ... Asia Pacific , and the Rest ...
Breaking Biology News(10 mins):
(Date:4/27/2017)... ... April 27, 2017 , ... Mitotech S.A, a Luxembourg based clinical stage biotechnology ... patients. LHON is a rare devastating genetic disease that leads to a sudden and ... group of 20 patients carrying 11778, 14484 and 3460 mutations and having experienced the ...
(Date:4/27/2017)... ... April 27, 2017 , ... Sierra Instruments ... based on capillary thermal mass flow technology provide exponentially more accurate mass flow ... Over 80% of all industrial processes—such as those involving chemical reactions, combustion, respiration, ...
(Date:4/27/2017)... -- Pendant Biosciences, Inc. (formerly Nanoferix, Inc.), a privately-held advanced ... technologies, today announced that it has been accepted into ... . Shawn Glinter , Founder ... are excited to become part of the JLABS @ ... to be the first Tennessee -based ...
(Date:4/26/2017)... ... April 26, 2017 , ... Led by ex-FDA official Peggy ... comes to Tampa, San Francisco and Boston in 2017. The 2016 sold-out ... such as Pfizer Inc., Teva Pharmaceuticals, Advaxis, Inc., Ocular Therapeutix Inc., Cell Culture ...
Breaking Biology Technology: