Navigation Links
Breakthrough in adult heart repair
Date:11/19/2013

Researchers from the Baylor College of Medicine and the Texas Heart Institute have discovered a new way to dramatically improve heart repair. The future goal is to use this knowledge to combat human cardiovascular disease by improving repair after a heart attack. The research has just been published in the scientific journal Development.

Professor James Martin led the team who uncovered the signaling pathway, called the Hippo pathway, that normally blocks heart repair in adult mice following injury. When the researchers removed certain signals, the hearts were able to regenerate. Martin's team showed that this was because the specialized heart cells, called cardiomyocytes, were able to proliferate much better: a feat that is essentially lost in normal injured hearts.

"The heart is very poor at repairing itself after various types of injury including the most common injury, the myocardial infarct. We were very excited to see full return of cardiac function in the Hippo-mutant hearts after injury. It was the culmination of a lot of hard work and also a little good luck," says Martin.

Lessons from development

Heart regeneration is possible during embryonic development, and even in newborn mice, but this ability is lost during adulthood. In previous work, published in Science, Martin's team identified a signaling pathway responsible for cardiomyocyte proliferation during development. Now they find that this same pathway controls proliferation and therefore regeneration in the adult heart too.

"We approached the problem from the perspective of developmental biologists. Based on our previous observations, we thought there was a good chance that Hippo also functioned as a repressor of adult heart muscle proliferation," adds Martin.

Other animals including some fish and amphibians can repair their hearts even as adults, but it is thought that this ability was lost during the course of evolution. Now
'/>"/>

Contact: Caroline Hendry
c.hendry@biologists.com
44-122-342-0007
The Company of Biologists
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Breakthroughs in Chikungunya research from A*STAR spell new hope for better treatment and protection
2. Interventional radiology: Potential breakthrough to treat mens enlarged prostate
3. WanderID Launches Breakthrough ID Product for Children, Seniors
4. Nanotechnology breakthrough could dramatically improve medical tests
5. NTU researchers study little mighty creature for scientific breakthrough
6. Research breakthrough: High brain integration underlies winning performances
7. Breakthrough technology focuses in on disease traits of single cells
8. Forest carbon monitoring breakthrough in Colombia
9. Queens University Belfast makes significant cancer breakthrough
10. Humanized mice developed at OHSU enable malaria research breakthrough at Seattle BioMed
11. An important breakthrough in the fight against muscular dystrophies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Breakthrough in adult heart repair
(Date:10/1/2014)... Finland , October 1, 2014 ... through in the life science field  ... technologies come and go over the years. Some ... standard. Photon upconversion is a novel detection technology ... recent years. Now, finally, this technology is becoming ...
(Date:9/30/2014)... Millions of tourists visit the Mediterranean each year, ... currently underway on Earth. Almost 1,000 alien species, ... from other seas through human activities. In the ... a multinational team of researchers analyzed data from ... Commission to show how the introduction of alien ...
(Date:9/30/2014)... California, San Diego, have completed the first comprehensive numerical ... uses the pixels in an image as data points ... , The researchers, led by J.S. Chen, the William ... of Engineering at UC San Diego, presented their findings ... conference in Pittsburgh this month. Chen also gave a ...
Breaking Biology News(10 mins):First-of-a-kind Solution for Utilizing Photon Upconversion 2Biodiversity in the Mediterranean is threatened by alien species 2First comprehensive meshfree numerical simulation of skeletal muscle tissue achieved 2
... study shows that human milk oligosaccharides, or HMO, produce short-chain ... infant gut. Not only that, the bacterial composition adjusts as ... though HMO are a major component of human milk, present ... the infant are not well understood. Furthermore, they,re virtually absent ...
... JOLLA, CA ---- Scientists at the Salk Institute for ... of plant proteins that play a role in the ... human nutrition, biorenewable chemicals and biofuels. Scoring a ... related proteins in thale cress plants ( Arabidopsis thaliana ...
... thanks to a paper-thin generator embedded in the sole ... little closer to reality. Scientists from the U.S. Department ... developed a way to generate power using harmless viruses ... tested their approach by creating a generator that produces ...
Cached Biology News:Study sheds new light on importance of human breast milk ingredient 2Discovery of plant proteins may boost agricultural yields and biofuel production 2Discovery of plant proteins may boost agricultural yields and biofuel production 3Berkeley Lab scientists generate electricity from viruses 2Berkeley Lab scientists generate electricity from viruses 3
(Date:10/1/2014)... 30, 2014 In response to ... to address sales, training and consumer engagement challenges, ... innovative mobile applications to turn their clients’ visions ... latest customized mobile app creations, are now featured ... In partnership with Toyota, StudioPMG created a robust ...
(Date:10/1/2014)... (PRWEB) October 01, 2014 The U.S. ... to Southern Illinois University Edwardsville as part of the ... initiative. The funding is co-administered by the Department of ... Biden, Secretary of Labor Thomas E. Perez and Secretary ... million in job-driven training grants to nearly 270 colleges ...
(Date:9/30/2014)... German . ... have demonstrated a new kind of building block for ... chips could be based on three-dimensional arrangements of nanometer-scale ... of the semiconductor industry CMOS fabrication of silicon ... collaborators at the University of Notre Dame are exploring ...
(Date:9/30/2014)... Sept. 30, 2014 Nematicide is a ... Nematodes are microscopic parasitic roundworms, found in massive ... other plants and animals. Nematicides have tended to ... properties promoting migration through the soil. A single ... plant-parasitic nematodes. With more than 10,000 species classified, ...
Breaking Biology Technology:Digital Agency Studio PMG Launches New Case Studies on Website 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 3U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 4A new dimension for integrated circuits: 3-D nanomagnetic logic 2A new dimension for integrated circuits: 3-D nanomagnetic logic 3Nematicides Market by Types (Fumigants, Organophosphates, Carbamate and Bio-Nematicides), Applications (Agrochemicals, Industrial, and Others), and Geography (North America, Europe, Asia-Pacific & ROW) - Global Trends & Forecasts to 2019 2
... conference at Grainger Hall. Madison, Wis. ... Wisconsin, according to the Coalition for Capital Growth and Research, ... Hall. , ,We believe [venture capital] is a worthwhile agenda ... partner at Venture Investors and the conferences founder. ...
... a look at how the large cap Midwest life science companies ... stock market. The results looked very positive for at least 75 ... market growth. , ,On the negative side, some of the poor ... our largest Big Pharma companies (namely Abbott Labs and Eli Lilly). ...
... I never cease to be amazed by the games that ... to goose up revenues and shore up profits. Most of ... Lately, things have gotten ridiculous enough to make one yearn ... calls. , ,And Im not talking about the nuisance of ...
Cached Biology Technology:Wisconsin investors seek regional partners and informed legislature 2Wisconsin investors seek regional partners and informed legislature 3Midwest small-cap life sciences turn in mixed third-quarter results 2Show customers leadership, not gamesmanship 2Show customers leadership, not gamesmanship 3
... The FastPlax Antibody is used to ... on the surface of infected cells as ... the basis of the FastPlax Titer Kit, ... just 25-48 hours. The FastPlax ...
Anti-Mouse Ly 6C.2 , Ascites (Clone 5075-3.6) (mouse IgG2b)...
b-Catenin (pSer675), phospho-specific...
Goat polyclonal to SIAH Interacting Protein ( Abpromise for all tested applications)....
Biology Products: