Navigation Links
Breakthrough in adult heart repair
Date:11/19/2013

Researchers from the Baylor College of Medicine and the Texas Heart Institute have discovered a new way to dramatically improve heart repair. The future goal is to use this knowledge to combat human cardiovascular disease by improving repair after a heart attack. The research has just been published in the scientific journal Development.

Professor James Martin led the team who uncovered the signaling pathway, called the Hippo pathway, that normally blocks heart repair in adult mice following injury. When the researchers removed certain signals, the hearts were able to regenerate. Martin's team showed that this was because the specialized heart cells, called cardiomyocytes, were able to proliferate much better: a feat that is essentially lost in normal injured hearts.

"The heart is very poor at repairing itself after various types of injury including the most common injury, the myocardial infarct. We were very excited to see full return of cardiac function in the Hippo-mutant hearts after injury. It was the culmination of a lot of hard work and also a little good luck," says Martin.

Lessons from development

Heart regeneration is possible during embryonic development, and even in newborn mice, but this ability is lost during adulthood. In previous work, published in Science, Martin's team identified a signaling pathway responsible for cardiomyocyte proliferation during development. Now they find that this same pathway controls proliferation and therefore regeneration in the adult heart too.

"We approached the problem from the perspective of developmental biologists. Based on our previous observations, we thought there was a good chance that Hippo also functioned as a repressor of adult heart muscle proliferation," adds Martin.

Other animals including some fish and amphibians can repair their hearts even as adults, but it is thought that this ability was lost during the course of evolution. Now
'/>"/>

Contact: Caroline Hendry
c.hendry@biologists.com
44-122-342-0007
The Company of Biologists
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Breakthroughs in Chikungunya research from A*STAR spell new hope for better treatment and protection
2. Interventional radiology: Potential breakthrough to treat mens enlarged prostate
3. WanderID Launches Breakthrough ID Product for Children, Seniors
4. Nanotechnology breakthrough could dramatically improve medical tests
5. NTU researchers study little mighty creature for scientific breakthrough
6. Research breakthrough: High brain integration underlies winning performances
7. Breakthrough technology focuses in on disease traits of single cells
8. Forest carbon monitoring breakthrough in Colombia
9. Queens University Belfast makes significant cancer breakthrough
10. Humanized mice developed at OHSU enable malaria research breakthrough at Seattle BioMed
11. An important breakthrough in the fight against muscular dystrophies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Breakthrough in adult heart repair
(Date:12/10/2014)... 2014 Research and Markets ( ... "Biometrics Market in Japan 2014-2018" report ... http://photos.prnewswire.com/prnh/20130307/600769 The integration of biometrics ... banking and upgradation of the driver,s license is ... market. Besides the aforementioned projects, biometrics is being ...
(Date:12/5/2014)... MOUNTAIN VIEW, Calif. , Dec. 4, 2014 ... and safety has boosted investments in new testing ... products has also given rise to a range ... driven by the requirements of Generation Y, which ... digital technologies. As a result, product development strategies ...
(Date:12/4/2014)... PALM BEACH GARDENS, Fla. , Dec. 3, ... identity management solutions, today announced that its DigitalPersona ... 4500 fingerprint readers have been deployed throughout ... Carolina , South Carolina ... network headquartered in Southern Pines, North ...
Breaking Biology News(10 mins):Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3
... plague belongs to a virulent family of bacteria called ... for food poisoning. These bacteria insert into their host ... -- among other things -- disrupting the cells' normal ... cell's internal skeleton. Now, a study published by Rockefeller ...
... the Translational Genomics Research Institute (TGen) in Phoenix, ... discover a gene--called Kibra--associated with memory performance in ... develop new medicines for memory-based diseases such as ... better understanding of how memory works at the ...
... low birth weights tend to have a much lower quality of ... a study published in the latest issue of the UK-based Journal ... birth weights of 1500g or less and compared them with a ... quality of life when it came to physical, emotional, cognitive and ...
Cached Biology News:A wolf in sheep's clothing: Plague bacteria reveal one of their virulence tricks 2Affymetrix 500K array used to identify memory gene 2Very low birth weight linked to reduced quality of life in pre-school children 2
(Date:12/17/2014)... Audacity, a leading California-based health and science ... Huntsworth Health Group, is proud to announce the addition ... role, Gonzales will serve as Senior Vice President of ... welcome a talent of Jamie’s caliber to the Audacity ... is a proven healthcare innovation leader and brand management ...
(Date:12/17/2014)...  United Therapeutics Corporation (NASDAQ: UTHR ) ... changes to Martine Rothblatt , Ph.D,s compensation program. ... United Therapeutics announced the promotion of Roger Jeffs ... David Zaccardelli , Pharm.D. to Executive Vice President ... Dr. Rothblatt,s title will change from Chairman and Chief ...
(Date:12/17/2014)... FRANCISCO, Calif. , Dec. 17, 2014 /PRNewswire/ ... of a Phase 2 study evaluating the investigational ... treatment of patients with severe, chronic itch who ... standard of care, including topical steroids and antihistamines. ... percent change in Visual Analog Scale (VAS) itch ...
(Date:12/15/2014)... METTLER TOLEDO is pleased to announce that the ... PVM technology , is now available. The new ... continuously captures high-resolution images under a wide range ... a report pairing the most relevant images to ... compelling blend of high resolution images and trend ...
Breaking Biology Technology:Audacity Welcomes Healthcare Communications Expert Jamie Gonzales as Senior Vice President of Client Services 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 3United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 4Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4New Real-Time In Situ Probe-Based Video Microscope from METTLER TOLEDO 2
... eight port right-angle BNC connectors to its product line. The ... for applications where a number of single or dual port BNC ... ... (PRWEB) April 29, 2009 -- Regal Electronics has added four, six ...
... - Strong Focus on the Markets of Pharma & Life Science ... of EUR0.40 per Share , The Annual ... per share following the record year in 2008. , ... results.,Gerresheimer achieved sales of EUR1.06 billion (prior year EUR957.7m) and,operating results ...
... MSEDMONTON, April 29 /PRNewswire-FirstCall/ - BioMS Medical Corp (TSX: MS), ... today announced that Mr. Kevin Giese, President and CEO, will ... development of a world class technology sector" as part of ... WHEN: Monday May 4th at ...
Cached Biology Technology:Regal Introduces Four, Six and Eight Port Filtered and Un-Filtered Right Angle BNC Connectors 22008 a Record Year for Gerresheimer 2BioMS Medical to present at Alberta Economic Forum in Geneva 2
... PCR Spots, Oligo Spots and complementary RNA ... microarray experiments. Use for glass array printing ... for reverse transcription, cDNA labeling, hybridization stringency ... Control PCR Spots and Oligo Spots, ...
Kit for Detection of Mitochondrial Membrane Potential...
EGTA, 50 g. Ethylene glycol-O,O-bis-[2-amino-ethyl]-N,N,N,N,-tetraacetic acid.Assay: > 99.0%. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
MOUSE ANTI HUMAN C-MYC aa171-188...
Biology Products: