Navigation Links
Breakthrough by Temple researchers could lead to new treatment for heart attack
Date:11/5/2013

heart failure, which can develop in the years following heart attack. To explore the significance of that elevation, they engineered mice to overexpress TNNI3K. They also created a second set of engineered mice, in which the protein was deleted. They then measured the animals' response to heart attack.

When overexpressed, Vagnozzi and colleagues found that TNNI3K promoted the injury of heart tissue from ischemia (blockage of blood flow) and reperfusion (restoration of blood flow) during and after a heart attack. TNNI3K overexpression in heart cells encouraged the production of superoxide, a reactive molecule from mitochondria, and activated p38 mitogen-activated protein kinase (MAPK), an enzyme that responds to stress signals in cells. The combined result of those activities was impaired mitochondrial function and heart cell death, which worsened ischemia/reperfusion injury. The opposite occurred in mice in which TNNI3K had been deletedsuperoxide production and p38 activation were reduced, and injury to the heart was limited. Reductions in heart dysfunction and fibrosis (hardening of heart tissue) were also observed.

The team next collaborated with the pharmaceutical company GlaxoSmithKline (GSK) to identify compounds that were capable of blocking TNNI3K activity. Treatment of wild-type (nonengineered) mice with the compounds following heart attack produced effects that were similar to those observed in mice with TNNI3K deletion.

The new findings open the way to a large-animal study and the development of a TNNI3K inhibitor that can be used in humans. According to Force, the team is planning to move ahead with a large-animal study, which will determine whether the drugs are effective in animals other than mice and allow for the development of pharmacological and safety profiles of the compounds. "Because TNNI3K is only expressed in the heart, drugs targeting it should be reasonably safe," Force noted.

A major aim of Temple's Ce
'/>"/>

Contact: Jeremy Walter
Jeremy.Walter@tuhs.temple.edu
215-707-7882
Temple University Health System
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Breakthrough research produces brighter, more efficiently produced lighting
2. ASU, Georgia Tech create breakthrough for solar cell efficiency
3. NTU scientists make breakthrough solar technology
4. Research breakthrough: Impaired autophagy associated with age-related macular degeneration
5. Scientific breakthrough reveals how vitamin B12 is made
6. Ionic liquid breakthrough in thermal electrical energy
7. Breakthrough: Sensors monitor cells at work
8. Breakthrough research of essential molecule reveals important targets in diabetes and obesity
9. University of Toronto breakthrough allows fast, reliable pathogen identification
10. Breakthrough in how pancreatic cancer cells ingest nutrients points to new drug target
11. NREL staff recognized for breakthrough technologies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... 20, 2014  The second annual Biometrics UnPlugged ... Tampa, Florida on September 15, ... Rahman, Director, Technology and Strategy at Samsung, and Philippe ... theme of this year,s event is Mobility at ... "Biometrics UnPlugged: Mobility at the Crossroads of ...
(Date:8/19/2014)... improve students, chances of completing introductory biology courses ... (UH) implemented a comprehensive student success program, employing ... , Through a grant from the Texas ... Biology and Biochemistry embarked on a pilot program ... non-majors and "Introductory Biology" for science majors. These ...
(Date:8/19/2014)... . Wind ... large amount of electricity is to be produced with renewable ... be stored during productive periods so that these fluctuations can ... adequate for the purpose. Science and industry are therefore working ... systems that used to be too expensive or unsophisticated to ...
Breaking Biology News(10 mins):Biometrics UnPlugged: Mobility at the Crossroads of Commerce & Privacy to Feature Interactive Sessions with Samsung and Experian 2University of Houson program earns kudos for improving grades, retaining students 2University of Houson program earns kudos for improving grades, retaining students 3Asian inventions dominate energy storage systems 2Asian inventions dominate energy storage systems 3
... or central nerve injury often leads to neuropathic pain, ... pain, hyperalgesia and allodynia, and which also results in ... pain for a long time, but its mechanisms of ... University of Traditional Chinese Medicine, China investigated the expression ...
... Yet the instrument of pricing global CO2 emissions could ... the 21st century, exceeding by far the 12 trillion ... to a study now published by scientists of the ... the interference of CO2 emission pricing with fossil fuel ...
... old saying goes: "Don,t judge a book by its cover." ... Bottlenose dolphins are the most common and well-known of their ... bottlenose dolphin might look similar to another, when you take ... there are differences. In fact, a recently published study in ...
Cached Biology News:Emissions pricing revenues could overcompensate profit losses of fossil fuel owners 2Dolphin genetic study provides revelations 2
(Date:8/20/2014)... WriteResult®, a leading provider of Electronic Patient Outcome ... myPROpad™ ePRO tablet with the addition of a touchscreen ... widely used and well-respected Patient Reported Outcome (PRO) instruments ... used during clinical trials and in other health care ... to demonstrate Health-Related Quality of Life outcomes (HRQoL) resulting ...
(Date:8/19/2014)... Shimadzu Scientific Instruments has introduced ... Nexera-i, adding to the company’s extensive line-up of ... intuitive operating environment, and full automation, the i-Series ... for conventional to ultra-high-speed analysis. , ... design so users can begin building the lab ...
(Date:8/19/2014)... IRVINE, Calif. (PRWEB) August 19, 2014 ... Indiegogo campaign to raise $200,000 to fund a ... diagnostic device. , This development is a ... one-size-fits-all model of care to the implementation of ... patient-centric method of practicing medicine. , Indiegogo contributions ...
(Date:8/19/2014)... August 19, 2014 XenoTech announces ... and cost-effective metabolite production from bioactive small molecules. ... platform, the technology enables convenient and timely assessment ... to XenoTech’s Vice President of Commercial Operations, Christian ... assessing clinical risk can be measured directly by ...
Breaking Biology Technology:EQ-5D™ Assessment Now Available for iPad 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 3Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 2Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 3Beyond Metabolite Identification, Testable Quantities Now Offered by XenoTech 2Beyond Metabolite Identification, Testable Quantities Now Offered by XenoTech 3
... or the "Company") (Amex: SNT ) today reported,financial results ... loss for the three month period ended December 31, 2007 ... loss of $1.1 million, or,$0.07 per share, for the three ... was primarily the result of a decrease in revenue and,an ...
... from pesticides to household cleaners will benefit from new ... scientists from the National Institutes of Health (NIH) and ... a new toxicity testing agreement. The concept behind this ... of the journal Science. , Two NIH institutes ...
... Children,s Research Hospital(R), the premier pediatric research and treatment ... ... Feb. 14 More than 60,000 callers,generated $6.1 million dollars ... Univision Radio, a division of Univision,Communications Inc. The radiothon, benefiting ...
Cached Biology Technology:Senesco Technologies Reports Second Quarter Fiscal 2008 Financial Results 2Senesco Technologies Reports Second Quarter Fiscal 2008 Financial Results 3Senesco Technologies Reports Second Quarter Fiscal 2008 Financial Results 4Senesco Technologies Reports Second Quarter Fiscal 2008 Financial Results 5Senesco Technologies Reports Second Quarter Fiscal 2008 Financial Results 6Senesco Technologies Reports Second Quarter Fiscal 2008 Financial Results 7Senesco Technologies Reports Second Quarter Fiscal 2008 Financial Results 8NIH collaborates with EPA to improve the safety testing of chemicals 2NIH collaborates with EPA to improve the safety testing of chemicals 3More than $6 Million Raised During Two-Day Event to Support Research and Treatment for Childhood Cancer and Other Catastrophic Diseases 2More than $6 Million Raised During Two-Day Event to Support Research and Treatment for Childhood Cancer and Other Catastrophic Diseases 3
Animal Origin Free...
IHC Detection Kit (Broad Spectrum AEC)....
...
... Antibody Modification Services ... including antibody labeling and antibody fragmentation. ... provides signals for visualization and quantitation ... assays, it is preferable to use ...
Biology Products: