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Breakthrough: With a chaperone, copper breaks through
Date:10/18/2010

rol of the copper ions. "This way, there is no risk of bringing several copper ions into the protein at the same time, which ultimately prevents harmful chemical reactions between the ions and the abundant chemical reagents within the cell," explains Prof. Ben-Tal. Once the ion has passed through the transporter into the cell, the transporter is ready to receive another copper ion if necessary.

Improving cancer drugs ― and more

The mechanism which transfers copper throughout the body may also be responsible for the transfer of the common chemotherapy drug Cisplatin. By studying how copper is transferred throughout the body, researchers may also gain a better understanding of how this medication and others are transferred into the cell.

With this information, says Prof. Ben-Tal, scientists could improve the transfer of the drug throughout the body, or develop a more effective chemotherapy drug. And that's not the only pharmaceutical dependent on the functioning of membrane proteins. "Sixty percent of drugs target membrane proteins," he explains, "so it's critical to learn how they function."


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Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert

Page: 1 2

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