Navigation Links
Breaking the mucus barrier unveils cancer cell secrets
Date:3/16/2011

Washington, D.C. (March 16, 2011) -- Measuring the mechanical strength of cancer cell mucus layers provides clues about better ways to treat cancer, and also suggests why some cancer cells are more resistant to drugs than others, according to Kai-tak Wan, associate professor of engineering at Northeastern University, Boston, Mass.

According to Wan, healthy tissues naturally secrete mucus to protect against infection. Cancer cells, however, produce far more mucus than healthy cells.

Mucus consists of protein "stalks" attached to sugar sidechains, or "branches." This tangled brush forms a physical barrier. When over-expressed, it can prevent drugs from reaching the cancer cells beneath. Over-expressed mucus also makes it easier for cancer cells to break away from surrounding cells and move through the body, or metastasize.

Wan's research partner, Robert B. Campbell, an associate professor of pharmaceutical sciences at Massachusetts College of Pharmacy and Health Sciences, Worcester, Mass., is investigating the use of chemical agents that limit the formation of this tangled mucus barrier so medicines can get through.

To determine how well those agents work, Wan used the nanoscale tip of an atomic force microscope to push against the mucus barrier. The less resistance it encountered, the less tangled the barrier.

Wan found that suppressing the formation of mucus sidechains significantly reduced the energy needed to pierce the mucus barrier in lung, breast, colorectal, pancreatic, and wild type (natural) ovarian cancer cells.

Yet the treatment registered barely any change in multi-drug resistant ovarian cancer cells. No one understands how those cells resist drugs that ordinarily kill wild type ovarian cancer.

Wan's research points to an important difference. The mucus layer formed by the two types of cells reacts differently to the same chemical treatment.

"How this phenomenon is related
'/>"/>

Contact: Charles E. Blue
cblue@aip.org
301-209-3091
American Institute of Physics
Source:Eurekalert

Page: 1 2

Related biology news :

1. Groundbreaking discovery may lead to stronger antibiotics
2. Breaking the barrier: Discovery of anti-resistance factors and novel ocean drugs
3. NIH funds development of resistance-breaking insecticides to reduce malaria transmission
4. Tufts students host Earth Day with groundbreaking ceremony for solar house
5. Breaking the ties that bind: New hope for biomass fuels
6. UTs Valentin Dragoi gets $1.2 million grant for groundbreaking approach to brain research
7. Research Councils UK sign groundbreaking MoU with Brazil
8. Groundbreaking model of heart disease rewarded with NIH Pioneer Award
9. Groundbreaking Videourology journal launched by Mary Ann Liebert, Inc.
10. Breaking the aphids code
11. Life Technologies, TGen and US Oncology partner on groundbreaking breast cancer sequencing research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... the Rim Fire was in full fury, raging swiftly ... entered the backcountry of Yosemite National Park in California,s ... park, the battle began to turn, enacting a case ... combine to fuel large, severe fires. , "When the ... where fire had been used as a management tool, ...
(Date:7/31/2014)... New Orleans, LA Dr. Oren Tessler, Assistant Professor ... Orleans School of Medicine, is part of a team ... success rate using a method to screen and select ... than 90% of the patients who underwent this surgery ... and also got a bonus cosmetic eyelid surgery. The ...
(Date:7/31/2014)... are familiar with Hibiscus flowers- they are an ... are commonly planted in the landscape. Some, like ... endangered species. , Only a relatively few botanists ... an equally beautiful and intriguing related group of ... of Hibiscus". , Brother of Hibiscus species are ...
Breaking Biology News(10 mins):The Rim Fire 1 year later: A natural experiment in fire ecology and management 2The Rim Fire 1 year later: A natural experiment in fire ecology and management 3The Rim Fire 1 year later: A natural experiment in fire ecology and management 4The Rim Fire 1 year later: A natural experiment in fire ecology and management 5Surgeons report significant migraine relief from cosmetic eyelid surgery technique 2Brother of Hibiscus is found alive and well on Maui 2
... as calcified, inert structures, but researchers at Columbia University ... important novel function of the skeleton. Theyve shown for ... organ that helps control our sugar metabolism and weight ... development of type 2 diabetes. The research, ...
... passed on from mother to child is decided very early ... ovary. In a cell division process that is unique to ... egg before it is fertilised. Using a powerful microscope, researchers ... how the molecular machinery functions that is responsible for chromosome ...
... Haven, Conn. It is not just whats in your genes, ... between species at least in yeast according to a ... Weve known for a while that the protein coding genes of ... author Michael Snyder , the Cullman Professor of Molecular ...
Cached Biology News:Research shows skeleton to be endocrine organ 2A unique arrangement for egg cell division 2Evolution is driven by gene regulation 2
(Date:7/31/2014)... 2014 Research and Markets has ... 2014-2018" report to their offering. ... study of the genetic material or genomes of an ... for the discovery and development of diagnostic and therapeutic ... conditions. Genomics is supported by three major product segments: ...
(Date:7/31/2014)... July 31, 2014 CollabRx, Inc. (NASDAQ: ... therapeutic decision-making in oncology, today announced that it will ... to discuss the Company's financial results for the first ... about the business in the current fiscal year. , ... on Thursday, August 14, 2014, at 5 p.m. EDT ...
(Date:7/31/2014)... 31, 2014 Senomyx , Inc. ... using proprietary taste science technologies to discover, develop, ... beverage, and ingredient supply industries, today reported financial ... ended the second quarter with $33.6 million in ... "During the past quarter Senomyx achieved another important ...
(Date:7/31/2014)... LONDON , July 31, 2014  Smith ... the global medical technology business, today announced its ... of the HAT-TRICK™ Lesser Toe Repair System. Comprised ... includes products for metatarsophalangeal (MTP) ligament repair and ... all-PEEK implant for proximal Inter-phalanges (PIP) fusion, also ...
Breaking Biology Technology:Global Genomics Market 2014-2018: Key Vendors are F. Hoffmann-La Roche, Life Technologies, Qiagen and Illumina 2CollabRx, Inc. Schedules First Quarter Fiscal Year 2015 Financial Conference Call and Business Update 2SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 2SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 3SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 4SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 5SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 6SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 7SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 8SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 9SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 10SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 11SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 12SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 13SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 14SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 15SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 16Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 2Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 3Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 4
... Iowa and the University of Missouri (MU) have developed a ... mimic the disease in human infants. The striking similarities between ... CF suggest that this new model will help improve understanding ... treatments. The study is published in the Sept. 26 issue ...
... More efficient. These are the qualities that drive science ... help to speed up computers. , Scientists at the ... contribution to this field by designing a new nanotechnology ... more efficient. The new process is described in today,s ...
... Scientific Accomplishment in Complement Inhibition and,Impact of Soliris ... Sept. 25 Alexion,Pharmaceuticals, Inc. (Nasdaq: ALXN ... for Best Biotechnology Product for Soliris(R) (eculizumab). The ... of Soliris, and the impact the drug is,having ...
Cached Biology Technology:Researchers develop new model for cystic fibrosis 2New nanoscale process created by UCSB scientists will help computers run faster and more efficiently 2New nanoscale process created by UCSB scientists will help computers run faster and more efficiently 3New nanoscale process created by UCSB scientists will help computers run faster and more efficiently 4New nanoscale process created by UCSB scientists will help computers run faster and more efficiently 5Alexion's Soliris(R) Receives 2008 Prix Galien USA Award for Best Biotechnology Product 2Alexion's Soliris(R) Receives 2008 Prix Galien USA Award for Best Biotechnology Product 3Alexion's Soliris(R) Receives 2008 Prix Galien USA Award for Best Biotechnology Product 4Alexion's Soliris(R) Receives 2008 Prix Galien USA Award for Best Biotechnology Product 5