Navigation Links
Breaking the barrier: Discovery of anti-resistance factors and novel ocean drugs
Date:2/14/2009

Investigations into coral disease, red tides and other marine environmental issues have led to discoveries of new chemicals as a source for pharmaceuticals. These chemicals function as antibiotics for microorganism providing survival advantages and may be usable in human health care.

Research by scientists from NOAA's National Ocean Service, The Medical University of South Carolina and North Carolina State University has found several compounds which exhibit very strong antibiotic, antifungal, and antiviral potential as well as some anti-cancer and angiogenesis activities. The research into coral disease has resulted in thousands of new bacterial isolates producing highly selective antimicrobial compounds yielding highly selective small peptide antibiotics.

VIDEO: This is NOAA Scientist Peter Moeller's Natural Products Laboratory at the NOAA Center for Coastal Environmental Health and Biomolecular Research with some explanation of equipment.

Click here for more information.

ss="imagecaption">Click here for more information.

Many of these novel antibiotics are advantageous, as they demonstrate no cytotoxic responses to human cells and may minimize negative side effects associated with those drugs in current usage. The researchers have yet to find a "known" resistant bacteria that cannot be made re-susceptible to current generation antibiotics, offering extended use of current drugs. We believe that one could apply many of these chemical mechanisms or novel pharmaceuticals to human disease resulting in a number of alternatives to deal with growing antibiotic resistance.

Observations from the sponge Agelas conifera's ability to protect itself against fouling and disease have led to the discovery of ageliferin derivatives that demonstrate very strong anti-biofilm activity. Compounds with this specific activity hold promise to increase the efficacy of current and out of use antibiotics because of their ability to inhibit and/or disperse the protective layer that infectious agents often produce to protect themselves. Such compounds are also finding potential use in other areas of human health as well, including cystic fibrosis, chemo-therapy, anti-fungal agents, and for use in medical stints and prosthetics.

VIDEO: This is a 6-minute interview, series of sound bites with NOAA scientist Peter Moeller about his natural products research into marine pharmaceuticals in corals and sponges.

Click here for more information.

Marine natural products hold much promise in combating both the trend of antibiotic resistance but also to discover new antibiotics. The one-two punch of discovering new antibiotics as well as novel chemicals that make older generation drugs more effective represents cutting edge science addressing a critical need in human health care.


'/>"/>

Contact: Ben Sherman
ben.sherman@noaa.gov
202-253-5256
NOAA Headquarters
Source:Eurekalert

Related biology news :

1. Groundbreaking discovery may lead to stronger antibiotics
2. Breaking harmful bonds
3. EPA funds ground-breaking Lyme disease research
4. Breaking news: Study revives Olympic prospects for amputee sprinter
5. Shell-breaking crabs lived 20 million years earlier than thought
6. BGSU undergraduates to pilot groundbreaking genome project
7. Scientists discover record-breaking hydrogen storage materials for use in fuel cells
8. Speed plays crucial role in breaking proteins H-bonds
9. Groundbreaking Canada-US study proves link between emissions and mercury pollution in fish
10. Groundbreaking Canada-US study proves link between emissions and mercury pollution in fish
11. Major step for drug discovery and diagnostics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/12/2017)... 12, 2017  Trovagene, Inc. (NASDAQ: TROV ... today announced that it has signed agreements with seven ... the Middle East for commercialization ... the first wave of international distribution agreements for Trovagene,s ... samples. The initial partners will introduce Trovagene,s ...
(Date:1/11/2017)... 2017  Michael Johnson, co-founder of Visikol Inc. a company originally ... been named to the elite "Forbes 30 Under 30" list in ... people in 20 fields nationwide to be recognized as a leader ... were selected. ... is currently a PhD candidate at Rutgers University. ...
(Date:1/4/2017)... -- For the thousands of attendees at this year,s International Consumer Electronics Show ... biometric measurement devices and services, will be featuring its new line of ... Medical,s special CES Exhibit Suite , the new upper arm and ... WellnessConnected product platform.  Continue ... ...
Breaking Biology News(10 mins):
(Date:1/17/2017)... , Jan. 17, 2017  An international ... of Medicine and St. Boniface Hospital Albrechtsen Research ... peripheral neuropathy, an unmet health need affecting nearly ... Journal of Clinical Investigation, their results identify small ... prevent and reverse neuronal injury in animal models ...
(Date:1/17/2017)... LEXINGTON, Mass. , Jan. 17, 2017   ... clinical stage biopharmaceutical company developing innovative inhaled therapies to ... candidate for treating fungal infections in the lungs of ... Infectious Disease Product" (QIDP) by the U.S. Food & ... , which is designed to speed the development of ...
(Date:1/17/2017)... 17, 2017  Only nine percent of U.S. consumers ... while only 16 percent believe health insurance companies do, ... 36 percent of U.S. adults believe health care providers ... compared to hospitals (23%). "We are in ... Wendy Salomon , vice president of reputation management and ...
(Date:1/17/2017)... ... January 17, 2017 , ... Pono Ola , a mind-body wellness firm ... today the official launch of its much-anticipated Pono Board: a re-invented fitness and anti-fatigue ... development for over a year, the patented Pono Board is the world’s only exercise ...
Breaking Biology Technology: