Navigation Links
Brandeis researchers use lasers, custom microscope to show gene splicing process in real time
Date:3/10/2011

From neurosurgery to bar code readers, lasers have been used in a myriad of applications since they were first introduced in the late 1950's. Now, with the work being done in Jeff Gelles' Lab at Brandeis University, researchers have developed a way to use lasers to study the splicing of pre-messenger RNA molecules, an essential process in creating proteins to sustain advanced organisms, including human life. This process of splicing is carried out by a cellular micro-machine called the spliceosome.

"Understanding how these micro-machines function inside the cell is important for many reasons," says Aaron A. Hoskins, a post-doctoral fellow who is a visiting scientist at Brandeis and first author of the paper "Ordered and Dynamic Assembly of Single Spliceosomes," which appears in the March 11, 2011 issue of Science.

"One is to further [decipher] basic biologywhat makes us humansand another is to understand how diseases related to these different machines come about," says Hoskins. By understanding how the process works, researchers may eventually be able to come up with therapies that fix the splicing process in cases where it is not working properly.

The paper reports on a five-year-long collaboration of three research laboratories with diverse expertise to study the splicing process. In addition to Hoskins, authors include: Gelles, the Aron and Imre Tauber professor of biochemistry and molecular pharmacology, whose lab developed the multi-laser imaging system used in the research; Larry Friedman a senior scientist in the biochemistry department who was a key contributor in building the elaborate microscope; Melissa J. Moore, a Howard Hughes Medical Institute Investigator and professor of biochemistry and molecular pharmacology at the University of Massachusetts Medical School and members of Virginia Cornish's laboratory in the Department of Chemistry at Columbia University whose lab synthesized the special dyes that were a
'/>"/>

Contact: Susan Chaityn Lebovits
lebovits@brandeis.edu
781-736-4027
Brandeis University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Brandeis study shows economic impact of dengue virus in Americas
2. Brandeis wins $1 million Keck Foundation grant to research active matter
3. NIH grant will boost electron microscopy at Brandeis
4. Brandeis and Smart Balance team up to advance heart-healthy research
5. Synthetic biology: TUM researchers develop novel kind of fluorescent protein
6. Researchers find drug that stops progression of Parkinsons disease in mice
7. Researchers discover new wintering grounds for humpback whales using sound
8. Berkeley Lab researchers illuminate laminins role in cancer formation
9. Researchers discover new shapes of microcompartments
10. Researchers find possible new treatment strategies for pancreatic cancer
11. Scripps oceanography researchers discover arctic blooms occurring earlier
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Brandeis researchers use lasers, custom microscope to show gene splicing process in real time
(Date:8/6/2015)... JOSE, Calif. , Aug. 6, 2015 /PRNewswire/ ... leading developer of human interface solutions, today announced ... TouchPad technologies on Windows 10. Microsoft leveraged Synaptics, ... to the operating system. Through ... drivers are fully certified with Microsoft,s Precision TouchPad ...
(Date:8/4/2015)... , Aug. 04, 2015 ... http://www.researchandmarkets.com/research/nvh7k2/digital_forensics ) has announced the addition of ... (Hardware, Software, and Service), Sub-Segment (Computer Forensics, ... Forensics), Tool Types, Service, Vertical and Region ... to their offering. By Component ...
(Date:7/31/2015)... de 2015 BGI llevará a cabo la 10ª ... al 25 de octubre de 2015, en ... su décimo aniversario este año. Desde su inauguración en ... reuniones anuales más influyentes del mundo en los campos ... científicas más dinámicas, entusiastas y amenas. ICG-10 ...
Breaking Biology News(10 mins):Synaptics Chosen for Human Interface Co-Development on Windows 10 2Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 2La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 3
... and computer programming equally. So when Rios who ... of Waterloo went looking for a graduate program, ... at Florida State University, which has about 35 graduate ... sciences in fall 2010. Now, along with his ...
... has elected ten new Fellows of the Society for ... in one or more of the following: research, teaching, ... during Entomology 2011 -- ESA,s 59th Annual Meeting -- ... Nevada (see: http://www.entsoc.org/entomology2011 ). Dr. Susan ...
... Neurotechnology , a provider of high-precision biometric identification ... new voice identification technology. VeriSpeak is now available ... as a new voice identification component in the ... VeriSpeak combines voiceprint identification and phrase recognition technologies, ...
Cached Biology News:New software aids fight against nitrates in Florida's groundwater 2New software aids fight against nitrates in Florida's groundwater 3Entomological Society of America names 2011 fellows 2Entomological Society of America names 2011 fellows 3Entomological Society of America names 2011 fellows 4Entomological Society of America names 2011 fellows 5Entomological Society of America names 2011 fellows 6Entomological Society of America names 2011 fellows 7Entomological Society of America names 2011 fellows 8Entomological Society of America names 2011 fellows 9Entomological Society of America names 2011 fellows 10Entomological Society of America names 2011 fellows 11Entomological Society of America names 2011 fellows 12Neurotechnology Introduces VeriSpeak Voice Identification Technology 2Neurotechnology Introduces VeriSpeak Voice Identification Technology 3Neurotechnology Introduces VeriSpeak Voice Identification Technology 4
(Date:9/2/2015)... 2, 2015 Biovista Inc. is ... the 2015 BeHEARD science challenge, a global competition hosted ... researchers, access to the latest life science innovations and ... and pathway analytics capability to support Steven Laffoon ... the study of Niemann-Pick Disease Type A (NPA), a ...
(Date:9/2/2015)... ENGLEWOOD, Colo. , Sept. 2, 2015 ... focused on developing treatments for urological and related conditions, ... of its planned private placement convertible note financing, raising ... two prior tranches totaling $3.175 million. ... stated, "Proceeds from this private placement are intended to ...
(Date:9/2/2015)... 2, 2015 Biovista Inc. ... BeHEARD von 2015 bekanntgeben zu können. Hierbei handelt ... Institute. Biovista unterstützt mit seiner Möglichkeit ... Behandlung anderer Krankheiten als denen, für die ein ... und sein Team bei der Wylder Nation Foundation ...
(Date:9/2/2015)... CA (PRWEB) , ... September 02, 2015 , ... ... faults in manufacturing equipment, to creating professional commercial video content, to analysis of ... views of fascinating events that go by too quickly to process with the ...
Breaking Biology Technology:Biovista Sponsors Wylder Nation Foundation's Research on Acid Sphingomyelinase Deficiency 2Aytu BioScience Completes $5.175 Million Private Placement 2Aytu BioScience Completes $5.175 Million Private Placement 3Biovista sponsert die Forschung von Wylder Nation Foundation zum Thema Mangel an saurer Sphingomyelinase 2Fastec Introduces the Quad-HD TS5-Q High-Speed Camera 2Fastec Introduces the Quad-HD TS5-Q High-Speed Camera 3
... to the constant whir of a computer's fan or held a ... , ,In fact, today's ultra-powerful computers generate so much heat ... mechanical engineering professor Tim Shedd . , ,Shedd ... method that early tests show can remove heat at rates up ...
... Wis. - The typical weekend bicycle rider might ... purchase. But for the professionals of the cycling world, it's ... , , Trek Bikes of Waterloo, Wis., operates under ... available technology for Lance Armstrong as he seeks a seventh ...
... the use of e-mail on vacation or the weekend? According ... email while on vacation. Most people check their email an average ... one mail address and a quarter of the respondents, said they ... , ,Original air date: Saturday, July 9, 2005 , , ...
Cached Biology Technology:A new tool for keeping computers cool 2A new tool for keeping computers cool 3A high-tech Trek at the Tour de France 2A high-tech Trek at the Tour de France 3
Gelatin 100 mm Culture Dishes...
BD Primaria 100 mm Cell Culture Dish, surface-modified polystyrene for enhanced cell culture. (200/ca) Packaging: 20 / sleeve, 200 / case ...
...
Mouse monoclonal antibody raised against a full length recombinant ATF3. NCBI Entrez Gene ID = ATF3...
Biology Products: