Navigation Links
Branch offices: New family of gold-based nanoparticles could serve as biomedical 'testbed'
Date:6/27/2011

Gold nanoparticles are becoming the well gold standard for medical-use nanoparticles. A new paper* by researchers from the National Institute of Standards and Technology (NIST) and the National Cancer Institute's Nanotechnology Characterization Laboratory (NCL) proposes not only a sort of gold nanoparticle "testbed" to explore how the tiny particles behave in biological systems, but also a paradigm for how to characterize nanoparticle formulations to determine just what you're working with.

Prospective uses of gold nanoparticles, says NIST chemist Vince Hackley, include high-precision drug-delivery systems and diagnostic image enhancers. Gold is nontoxic and can be fashioned into particles in a range of sizes and shapes. By itself, gold doesn't do much biologically, but it can be "functionalized" by attaching, for instance, protein-based drugs along with targeting molecules that cluster preferentially around cancer cells. The nanoparticles are generally coated as well, to prevent them from clumping together and to avoid rapid clearance by the body's immune system.

NCL's Anil Patri notes that the coating composition, density and stability have a profound impact on the nanomaterial safety, biocompatibility (how well the nanoparticles distribute in the body), and efficacy of the delivery system. "Understanding these parameters through thorough characterization would enable the research community to design and develop better nanomaterials," he says.

To facilitate such studies, the NIST/NCL team set out to create a nanoparticle testbeda uniform, controllable core-shell nanoparticle that could be made-to-order with precise shape and size, and to which could be attached nearly any potentially useful functionality. Researchers then could study how controlled variations fared in a biological system.

Their trial system is based on regularly shaped branching molecules called dendrons, a term derived from the Greek word for "tree."
'/>"/>

Contact: Michael Baum
michael.baum@nist.gov
301-975-2763
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

Page: 1 2

Related biology news :

1. NOAA awards $22.5 million to Harbor Branch/FAU and UNCW for new cooperative institute
2. MDC researchers discover molecule responsible for axonal branching
3. Research team finds first evolutionary branching for bilateral animals
4. Top-Three US Bank Chooses CIC Electronic Signature Technology for Branch-Wide Deployment
5. Study finds surprising new branches on arthropod family tree
6. Telestone Technologies Corporation Opens Four New Branch Offices
7. Queens University Belfast researchers trace octopuses family tree
8. Children distressed by family fighting have higher stress hormones
9. Planetary "first family" discovered by astronomers using Gemini and Keck Observatories
10. Planetary first family discovered by astronomers using Gemini and Keck Observatories
11. Making the ultimate family sacrifice
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Branch offices: New family of gold-based nanoparticles could serve as biomedical 'testbed'
(Date:11/7/2014)... , Nov. 7, 2014  In conjunction with the ... Police Departments, The Community Foundation of the Verdugos has ... DNA JUSTICE PROJECT," a $250,000 initiative to keep the ... phase. In its first six months of existence, the Lab ... evidence support for local law enforcement. "Because our ...
(Date:11/6/2014)... metastasis, yet progress in preventing and treating migratory ... particularly challenging to design drugs that work against ... biology at Harvard Medical School. , "Unfortunately, ... metastasized." , Gujral and colleagues have now identified ... understand how metastasis begins. Their findings may also ...
(Date:11/5/2014)... in the UTSA College of Sciences, is one ... receive a two-year $300,00 National Science Foundation (NSF) ... funding supports President Obama,s BRAIN Initiative, a federal ... that will demystify complex brain processes. , ... broken into the interactions of multiple components, each ...
Breaking Biology News(10 mins):Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2Migration negation 2Migration negation 3UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3
... An article released today in PLoS ... Imported Wildlife Products, from a collaborative study led ... Prevention (CDC), identified evidence of retroviruses and herpesviruses ... U.S. international airports, including John F. Kennedy International ...
... trees line the banks of the Chattooga River. The dead ... and picturesque views to visitors. These Eastern hemlocks are dying ... them. One tiny insect, the hemlock woolly adelgid, ... eastern U.S. in Richmond, Va., in the 1950s. In 2003, ...
... The recent discovery that bisabolane, a member of ... and flavorings, holds high promise as a biosynthetic alternative ... the green energy community and the trucking industry. Now ... of Energy (DOE),s Joint BioEnergy Institute (JBEI) has determined ...
Cached Biology News:Study establishes importance of tracking diseases associated with illegal wildlife trade 2Study establishes importance of tracking diseases associated with illegal wildlife trade 3UGA study offers hope for hemlock attack 2Clearing a potential road block to bisabolane 2Clearing a potential road block to bisabolane 3
(Date:11/15/2014)... Algenol Biofuels will present at CleanEquity Monaco 2015 ... Monaco . Logo - ... invitation-only event hosted by Innovator Capital, the London ... and sponsors include Prince Albert II of ... PR Newswire, the Monte-Carlo SBM, Oceanographic Museum of ...
(Date:11/15/2014)... 2014  F. David Rollo , MD, Ph.D., ... a Pinnacle Professional in the field of Medicine as ... Point, LLC. Cell Point is a privately ... Colorado , Houston and ... technology platforms, ethylenedicysteine drug conjugate technology ("EC Technology"), In-Situ ...
(Date:11/12/2014)... -- ReachBio Research Labs (a registered trade name of ReachBio ... that it has signed an agreement with Funakoshi Co., ... non-exclusive distribution rights to ReachBio,s human primary cell product ... Japan . Under a companion agreement, Funakoshi ... Japanese drug development companies. Photo - ...
(Date:11/12/2014)... Innovative Formulations celebrates one ... GMP compliance with InstantGMP™ MES! Their team has ... for creating high quality nutraceuticals. , “Beginning with ... with the final BPR approval - it's easy ... the process,” explains Innovative Formulations Quality Assurance Manager ...
Breaking Biology Technology:Algenol Biofuels Selected to Present at CleanEquity Monaco 2015 2F. David Rollo, MD, Ph.D., FACC, FACNP is recognized by Continental Who's Who as a Pinnacle Professional 2Funakoshi to Distribute ReachBio Research Labs Human Primary Cell Products in Japan 2Funakoshi to Distribute ReachBio Research Labs Human Primary Cell Products in Japan 3Innovative Formulations Achieves GMP Compliance and Success with InstantGMP™ MES 2
... Wisconsin Technology Council has published the first-ever magazine ... highlights the states research base, technology-transfer process, company ... I-Q Corridor that joins Chicago, Wisconsin and Minneapolis-St. ... to post excerpts from Life Sciences: Wisconsin ...
... fares poorly when it comes to attracting federal dollars. ... five in getting a return on the federal tax ... home the bacon, Wisconsin is mostly oink and little ... Wisconsin research institutions and, increasingly, its high-tech companies, compete ...
... first installment - From the mind to the ... The Wisconsin Technology Council has published the ... publication highlights the states research base, technology-transfer process, company ... Corridor that joins Chicago, Wisconsin and Minneapolis-St. Paul. , ...
Cached Biology Technology:Life Sciences: Wisconsin- The Smart Choice 2Life Sciences: Wisconsin- The Smart Choice 3Life Sciences: Wisconsin- The Smart Choice 4Life Sciences: Wisconsin- The Smart Choice 5Life Sciences: Wisconsin- The Smart Choice 6Life Sciences: Wisconsin- The Smart Choice 7Heres one federal program where Wisconsin has gained some hard-earned ground 2Heres one federal program where Wisconsin has gained some hard-earned ground 3WTC launches Wisconsin Life Science magazine 2
FITC~Bovine Serum Albumin...
Bovine Serum Albumin Heat Shock Diagnostic Grade Powder...
Ready for formulation or direct injection into animals Provided in convenient 100, 250, 1000 and 10,000 nmol sizes HPLC purified, salt free, sterile filtered, and endotoxin tested ...
, Premium quality synthesis and purification , You provide the sequence, we'll do the rest , Rigorous quality control , Your choice of purification method, amount and format , Available annealed...
Biology Products: