Navigation Links
Branch offices: New family of gold-based nanoparticles could serve as biomedical 'testbed'
Date:6/27/2011

Gold nanoparticles are becoming the well gold standard for medical-use nanoparticles. A new paper* by researchers from the National Institute of Standards and Technology (NIST) and the National Cancer Institute's Nanotechnology Characterization Laboratory (NCL) proposes not only a sort of gold nanoparticle "testbed" to explore how the tiny particles behave in biological systems, but also a paradigm for how to characterize nanoparticle formulations to determine just what you're working with.

Prospective uses of gold nanoparticles, says NIST chemist Vince Hackley, include high-precision drug-delivery systems and diagnostic image enhancers. Gold is nontoxic and can be fashioned into particles in a range of sizes and shapes. By itself, gold doesn't do much biologically, but it can be "functionalized" by attaching, for instance, protein-based drugs along with targeting molecules that cluster preferentially around cancer cells. The nanoparticles are generally coated as well, to prevent them from clumping together and to avoid rapid clearance by the body's immune system.

NCL's Anil Patri notes that the coating composition, density and stability have a profound impact on the nanomaterial safety, biocompatibility (how well the nanoparticles distribute in the body), and efficacy of the delivery system. "Understanding these parameters through thorough characterization would enable the research community to design and develop better nanomaterials," he says.

To facilitate such studies, the NIST/NCL team set out to create a nanoparticle testbeda uniform, controllable core-shell nanoparticle that could be made-to-order with precise shape and size, and to which could be attached nearly any potentially useful functionality. Researchers then could study how controlled variations fared in a biological system.

Their trial system is based on regularly shaped branching molecules called dendrons, a term derived from the Greek word for "tree." Dendron chemistry is fairly new, dating from the 1980s. They're excellent for this use, says NIST researcher Tae Joon Cho, because the individual dendrons are always the same size, unlike polymers, and can readily be modified to carry "payload" molecules. At the same time, the tip of the structurethe "tree's" trunkis designed to bond easily to the surface of a gold nanoparticle.

The team made an exhaustive set of measurements so they could thoroughly describe their custom-made dendron-coated nanoparticles. "There aren't a lot of protocols around for characterizing these materialstheir physical and chemical properties, stability, et cetera," Hackley says, "so, one of the things that came out of the project is a basic series of measurement protocols that we can apply to any kind of gold-based nanoparticle."

Any single measurement technique, he says, is probably inadequate to describe a batch of nanoparticles, because it likely will be insensitive to some size ranges or confused by other factorsparticularly if the particles are in a biological fluid.

The new NIST/NCL paper provides the beginnings of a catalog of analysis techniques for getting a detailed lowdown on nanoparticles. These techniques include nuclear magnetic resonance spectroscopy, matrix-assisted laser desorption/ionization mass spectrometry, dynamic light scattering, ultra-violet/visible spectroscopy and X-ray photoelectron spectroscopy. The dendron-coated nanoparticles also were tested for stability under "biologically relevant" conditions of temperature, acidity and some recognized forms of chemical attack that would take place in the bloodstream. In vitro biological tests are pending.


'/>"/>

Contact: Michael Baum
michael.baum@nist.gov
301-975-2763
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

Related biology news :

1. NOAA awards $22.5 million to Harbor Branch/FAU and UNCW for new cooperative institute
2. MDC researchers discover molecule responsible for axonal branching
3. Research team finds first evolutionary branching for bilateral animals
4. Top-Three US Bank Chooses CIC Electronic Signature Technology for Branch-Wide Deployment
5. Study finds surprising new branches on arthropod family tree
6. Telestone Technologies Corporation Opens Four New Branch Offices
7. Queens University Belfast researchers trace octopuses family tree
8. Children distressed by family fighting have higher stress hormones
9. Planetary "first family" discovered by astronomers using Gemini and Keck Observatories
10. Planetary first family discovered by astronomers using Gemini and Keck Observatories
11. Making the ultimate family sacrifice
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Branch offices: New family of gold-based nanoparticles could serve as biomedical 'testbed'
(Date:3/10/2016)... , March 10, 2016 ... market research report "Identity and Access Management Market by ... Compliance, and Governance), by Organization Size, by Deployment, by ... published by MarketsandMarkets, The market is estimated to grow ... Billion by 2020, at a Compound Annual Growth Rate ...
(Date:3/8/2016)... RALEIGH, N.C. , March 8, 2016 /PRNewswire/ ... biometric sensor technology, today announced it has secured ... led by GII Tech, a new venture fund ... LLC, with additional participation from existing investors TDF ... use the funds to continue its triple-digit growth ...
(Date:3/2/2016)... DUBLIN , March 2, 2016 /PRNewswire/ ... the addition of the "Global Biometrics ... to their offering. --> ... the "Global Biometrics as a Service ... --> Research and Markets ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... CA (PRWEB) , ... April 29, 2016 , ... Summit ... (NSCF) to support the development of a patient-specific stem cell therapy for the treatment ... the lab of Dr. Jeanne Loring at The Scripps Research Institute in San Diego, ...
(Date:4/29/2016)... 29, 2016 Elekta is pleased ... to its industry-leading treatment planning software, is available for ... Monaco version 5.11 provides significant performance speed ... speeds up to four times faster than in previous ... industry,s gold standard Monte Carlo ...
(Date:4/28/2016)... Q BioMed Inc. (OTCQB:QBIO), ...  was featured in an article he wrote on ... To Tread: http://www.lifescienceleader.com/doc/accelerators-enter-when-vcs-fear-to-tread-0001 ... an essential business journal for life science executives ... Big Pharmas. Their content is designed to inform ...
(Date:4/28/2016)... ... 28, 2016 , ... Next week on May 5 at ... technologies for tissue stem cell counting and expansion to gene-editing scientists and other ... CRISPR-based Genome Engineering in Burlington, Massachusetts. , The attention of most gene-editing scientists ...
Breaking Biology Technology: