Navigation Links
Brain tweak lets sleep-deprived flies stay sharp
Date:7/31/2008

St. Louis, July 31, 2008 Staying awake slows down our brains, scientists have long recognized. Mental performance is at its peak after sleep but inevitably trends downward throughout the day, and sleep deprivation only worsens these effects.

For the first time, researchers at Washington University School of Medicine in St. Louis have found a way to stop this downward slide. When scientists genetically tweaked a part of the brain involved in learning and memory in fruit flies, the flies were unimpaired even after being deprived of sleep.

"The ultimate goal is to find new ways to help people like the armed forces and first responders stay alert and on top of things when they have to be awake for extended periods of time," says Shaw. "We have drugs now that can keep people awake, but they're addictive and lose their effectiveness with repeated use. This research should help us find methods for maintaining mental acuity that have more specific effects, are less addictive and retain their potency."

The results appear in Current Biology on Aug. 5.

Shaw's lab was the first to show that fruit flies enter a state of inactivity comparable to sleep. They demonstrated that the flies have periods of inactivity where greater stimulation is required to rouse them. These periods begin at night; like human sleep they are cyclic over the course of the night, with sleep cycles lasting 20-25 minutes. Also like humans, flies deprived of sleep one day will try to make up for the lost time by sleeping more the next day, a phenomenon referred to as increased sleep drive or sleep debt.

For the new study, first author Laurent Seugnet, Ph.D., a postdoctoral fellow, revealed that sleep deprivation impairs learning in flies. Seugnet put them through multiple runs of a maze with two options: one lighted vial with the bitter-tasting quinine in it and one darkened but quinine-free vial. Flies are instinctively drawn to light, but they wan
'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. New study shows compounds from soy affect brain and reproductive development
2. Obesity predisposition traced to the brains reward system
3. N.Y. research team discovers how antidepressants and cocaine interact with brain cell targets
4. Antimicrobial sutures reduce infections in brain shunt surgery, study finds
5. Adult stem cells activated in mammalian brain
6. Scientists demonstrate means of reducing Alzheimers-like plaques in fly brain
7. Cross fire from the brain makes patients tremble
8. Scientists learn how food affects the brain
9. Big brains arose twice in higher primates
10. Researchers reveal types of genes necessary for brain development
11. Following traumatic brain injury, balanced nutrition saves lives
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/8/2015)... FRANKLIN LAKES , N.J. and NEW YORK ... and Company) and Guidepoint today announced ... selected start-up healthcare companies with free access to Guidepoint,s ... mentoring several start-ups that are developing cutting-edge technologies to ... of a dedicated Guidepoint research manager, each start-up entrepreneur ...
(Date:7/7/2015)... Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company") a biometric ... revised version of one of its first 30 second commercials will ... New York , Chicago , ... metro areas.    , , , , ... the cards in your wallet and keep your identity secure. ...
(Date:6/30/2015)... -- Genisphere announced Tom Bliss ... develop Genisphere,s therapeutics capabilities and portfolio. Mr. Bliss comes ... of the last 25 years in leadership positions at ... & Johnson. Tom started his career in Investment Banking, ... He graduated from Dartmouth College with a BA in ...
Breaking Biology News(10 mins):BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3Wocket Smart Wallet Commercials Airing on CNBC to Showcase This Summer's Must- Have Tech Product 2Wocket Smart Wallet Commercials Airing on CNBC to Showcase This Summer's Must- Have Tech Product 3Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3
... A scientific project funded by the BBVA Foundation and conducted ... (CSIC) explored around 100 kilometers of practically uncharted Atlantic beach ... the years 2006 and 2007. In the course of their ... hope for the survival of the leatherback turtle. This species ...
... , Now that Olympia is approaching, the Chinese authorities ... large cities with different measures. For example, the car ... ordered not to use 70 percent of all company ... even or odd days - in accordance with their ...
... A new study by researchers at The University of Texas ... to continue the current practice of retesting women during their ... tested positive for the infection previously. Group B Streptococcus, ... harmless to carriers but in some cases can be deadly ...
Cached Biology News:GKSS membranes reduce air pollution in Beijing 2Recurrence of group B strep high in subsequent pregnancies, say UT Houston obstetricians 2
(Date:7/29/2015)... , July 29, 2015 US-Australian drug ... ) today confirmed it is committed to progressing its ... soon as practicable and to ensure the Company delivers ... Executive Officer, Iain Ross , said the Company ... the lead pre-clinical programs, discovery programs and academic partnerships ...
(Date:7/29/2015)... ... July 29, 2015 , ... G-CON Manufacturing, Inc., the leading ... 2nd generation cell therapy POD® design. The 2nd generation portfolio not only delivers ... new POD® design. , “G-CON first offered our miniPOD CT product line ...
(Date:7/29/2015)... SAN DIEGO , July 29, 2015  Pfenex ... quarter 2015 financial results will be released on Thursday, ... 8:30 am Eastern Time, Pfenex management will host a ... a business update.  A press release outlining the financial ... to the call. Please call 1-866-376-8058 (US) ...
(Date:7/29/2015)... ... 29, 2015 , ... Finding gooey or crusty material in the corner of ... a considerable number of terms in popular use to describe it, ophthalmologists call it ... of mucus, blood cells, skin cells and dust, but until now there has been ...
Breaking Biology Technology:Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 3Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 4Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 5Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 6Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 7Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 8Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 9Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 10G-CON Manufacturing Launches Their 2nd Generation Cell Therapy Cleanroom POD® 2G-CON Manufacturing Launches Their 2nd Generation Cell Therapy Cleanroom POD® 3Pfenex To Report Second Quarter 2015 Results and Provide Business Update on Thursday, August 13, 2015 2What Are ‘Eye Crusties’ Made Of? uBiome Invites Citizen Scientists to Find Out 2What Are ‘Eye Crusties’ Made Of? uBiome Invites Citizen Scientists to Find Out 3What Are ‘Eye Crusties’ Made Of? uBiome Invites Citizen Scientists to Find Out 4
... Aug. 24 Advanced Instruments has introduced a next-generation Web ... purchasing osmometers, cryoscopes, and microbiological laboratory instruments. The site, ... , was developed from the perspective of the Web ... scientific materials, and technical support. , , ...
... , BASKING RIDGE, N.J., Aug. 24 ... the development of antithrombotic therapeutic aptamers with active control ... the first Phase I study of a subcutaneous administration ... a double-blind, randomized, placebo-controlled, single ascending dose study to ...
... , SAN DIEGO, Aug. 24 ... announced that Mark Booth has joined the Company as Chief ... commercial and business development experience to Orexigen. Most recently ... where he presided over the commercial, medical and scientific affairs, ...
Cached Biology Technology:Advanced Instruments Introduces Next-Generation Web Site 2Regado Biosciences Announces First Patient Enrolled In Phase 1 Study Of Subcutaneously Administered Reg1 Anticoagulation System 2Orexigen(R) Therapeutics Appoints Mark Booth Chief Commercial Officer 2
... PHD2000 syringe pump series combines Harvard Apparatuss best ... and a wide range of configuration options. A ... dimensions of syringes from all the major manufacturers. ... all the pertinent information from across the lab. ...
Mouse monoclonal antibody to RAD51L3 - RAD51-like 3 (S. cerevisiae)...
... you to store and manage very large ... secure central relational database. Storing and managing ... resource for clone tracking and enables you ... analysis. LabShare software integrates seamlessly with Invitrogen's ...
... A and Protein G bind specifically to ... A and Protein G conjugates are commonly ... (antibodies) and immunoglobulin subtypes from serum, hybridoma ... biological fluids. These reagents are also commonly ...
Biology Products: