Navigation Links
Brain tumors: Tissue stem cell turning into tumor stem cell
Date:4/1/2010

els. This enables the cells to migrate into distant brain regions and, thus, to generate the typical coral-like growth of glioblastoma.

"We recognize brain stem cells specifically by their Tlx production. If we boost it, the tissue stem cell turns into a cancer stem cell from which malignant glioblastomas arise. Therefore, we are now able, for the first time, to hold brain stem cells directly responsible for the formation of brain tumor stem cells," Gnther Schtz explains.

The researchers expect to be able to develop new therapies to treat glioblastoma on the basis of these results from fundamental cell biology research. Tlx seems to play its fatal role not only in mouse brains. Studying tumor tissue from glioblastoma patients, Lichter and Reifenberger discovered that the Tlx gene is often present in multiple copies and, thus, more Tlx protein is produced. "Apparently, human brain tumor stem cells also depend on Tlx. Therefore, we can now try to develop therapies that are directed very specifically against Tlx producing cells," said Schtz describing the next steps. The mice whose brain stem cells overproduce Tlx are an ideal model system for such investigations.


'/>"/>

Contact: Dr. Sibylle Kohlstdt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. Impaired brain connections traced to schizophrenia mutation
2. New brain nerve cells key to stress resilience, UT Southwestern researchers find
3. Insulin-like signal needed to keep stem cells alive in adult brain
4. New understanding of proteins role in brain
5. New period of brain plasticity created with transplanted embryonic cells
6. Sex on the brain: Doublesex gene key to determining fruit fly gender
7. My brain made me do it
8. Psychopaths brains wired to seek rewards, no matter the consequences
9. The scientific brain
10. Which came first: Religion or the brain?
11. Ritalin boosts learning by increasing brain plasticity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)... April 14, 2015  HYPR Corp. today announced ... ® ) Alliance tm , an industry consortium ... commit to share technology and collaborate to deliver ... interoperable, more secure and private, and easier to ... verification that protects sensitive user information and eliminates ...
(Date:4/13/2015)... April 13, 2015 According ... "Global Biometrics Market Forecast & Opportunities, 2020", the global ... of around 14% till 2020. The biometrics market ... scale implementation and review of biometric management systems. ... new products with greater efficiency, are resulting in ...
(Date:4/10/2015)... , April 10, 2015 Research ... of the "Security Competitive Profiles - NEC" ... , NEC will continue to supply a ... the market, with a company focus on the development ... Winning opportunities in the Asia-Pacific ...
Breaking Biology News(10 mins):HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2NEC Security Competitive Profile 2015 2
... Active management of the third stage of labour means ... approach, reveals a thesis from the University of Gothenburg, Sweden, ... studies in the West have shown that heavy bleeding following ... thesis, midwife and researcher Elisabeth Jangsten decided to look at ...
... ANN ARBOR, Mich---University of Michigan researchers have determined ... tumors, providing new evidence that the deadliest form of ... cancer stem cell model. In addition, the researchers ... by switching various genes on and off, making the ...
... the massive glaciers of the greater Himalayan region are ... help the region,s communities prepare for the many ways ... to a new report. Programs that integrate health, education, ... address these impacts, the report states. "The extremely high ...
Cached Biology News:Active management of the third stage of labor reduces risk of bleeding 2More evidence that melanoma does not conform to the cancer stem cell model 2More evidence that melanoma does not conform to the cancer stem cell model 3Time to prepare for climate change 2Time to prepare for climate change 3Time to prepare for climate change 4Time to prepare for climate change 5
(Date:4/30/2015)... -- Roka Bioscience, Inc. (NASDAQ: ROKA ), a molecular ... the detection of foodborne pathogens, announced plans to release ... on May 7, 2015 after the close of the ... a conference call at 4:30 p.m. Eastern Time on ... results. During the conference call, material information concerning the ...
(Date:4/30/2015)... 2015 Nitto Avecia, a leading ... increased capacity and production capability to serve biotechnology ... and service fulfillment continues to drive Nitto Avecia ... throughput capacities. , In Fall 2014, ... process equipment at its Milford, MA facility, which ...
(Date:4/30/2015)...  The Paul G. Allen Family Foundation announced today ... six groups of researchers with projects at the frontier ... growing mature human brain cells in the laboratory. The ... over three years.  "This new cohort ... significant because the field of neuronal maturation is at ...
(Date:4/30/2015)... WuXi PharmaTech (Cayman) Inc. ("WuXi" or the "Company") (NYSE: ... provider, today announced that its board of directors has ... 2015, from a consortium (the "Consortium") led by Dr. ... chief executive officer of the Company, and Ally Bridge ... "Transaction") involving the acquisition of all outstanding shares of ...
Breaking Biology Technology:Roka Bioscience to Report First Quarter 2015 Financial Results On May 7, 2015 2Biotechnology Manufacturer Nitto Avecia Expands Capacity to Meet Client Demand 2The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 2The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 3The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 4The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 5WuXi PharmaTech Announces Receipt of Proposal 2WuXi PharmaTech Announces Receipt of Proposal 3WuXi PharmaTech Announces Receipt of Proposal 4WuXi PharmaTech Announces Receipt of Proposal 5WuXi PharmaTech Announces Receipt of Proposal 6
... in the sky. It's a bird. It's a plane. It's super ... in a single bound. Indeed, lately the media has been saturated ... result from the mass exodus of Baby Boomers from the workforce. ... that this trend and its impacts on businesses are black and ...
... Wis. - Fueled by the launch of a ... the world market share leader in the compact ultrasound ... issued by Klein Biomedical Consultants . , ,Klein ... Healthcare has captured 43 percent of the compact ultrasound ...
... Wauwatosa, Wis . - In the medical field, the ... is the sheriff that sets and maintains the standards ... and accreditation of healthcare organizations. , ,It recently shortened ... carry just as much weight. , ,One of these ...
Cached Biology Technology:Shades of gray: Business impacts of an aging workforce 2Shades of gray: Business impacts of an aging workforce 3Shades of gray: Business impacts of an aging workforce 4Shades of gray: Business impacts of an aging workforce 5Shades of gray: Business impacts of an aging workforce 6GE Healthcare leads compact ultrasound market 2Portal to e-records boosts care at Children's Hospital 2Portal to e-records boosts care at Children's Hospital 3