Navigation Links
Brain tumor invasion along blood vessels may lead to new cancer treatments
Date:7/8/2014

chniques to see how tumor cells migrate through the brain and interact with other cells and blood vessels.

In the current study, Dr. Sontheimer's team showed that almost all of the glioblastoma cells outside the main tumor mass were located in the space between the astrocytic endfeet and the blood vessel outer surface. By using the meshwork of small blood vessels as a scaffold, glioblastoma cells were able to migrate along the vessels and extract nutrients from the blood for themselves.

"The vast majority of tumor cells are associated with blood vessels. These cells appear to be using the vessels as highways to travel great distances within the brain," said Dr. Sontheimer.

In addition, the findings revealed the glioblastoma cells hijacked control over the blood flow by taking it away from the astrocytes. As a result, tight junctions became loose, which led to a breakdown in the BBB. Dr. Sontheimer and his colleagues were surprised that very small groups of tumor cells, even individual cells, were sufficient to weaken the BBB early in the disease process.

"Evidence from our models suggests that early in the disease, invading tumor cells are not completely protected by the blood-brain barrier and may be more vulnerable to drugs delivered to the brain via the blood. If these findings hold true in humans, treatment with anti-invasive agents might be beneficial in newly diagnosed glioblastoma patients," said Dr. Sontheimer. He added that localized breaches in the BBB may allow regionally precise delivery of drugs to attack tumor cells even in the earliest stage.

"Dr. Sontheimer's findings provide us with new perspectives on how glioblastoma cells successfully invade within the brain and control blood flow to their advantage. These findings have the potential to change current approaches to treating glioblastoma," said Jane Fountain, Ph.D., program director in charge of NINDS' brain tumor portfolio.

Further resea
'/>"/>

Contact: Barbara McMakin
nindspressteam@ninds.nih.gov
301-496-5751
NIH/National Institute of Neurological Disorders and Stroke
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. REST is crucial for the timing of brain development
2. Holding a mirror to brain changes in autism
3. Strong scientific evidence that eating berries benefits the brain
4. The Japanese traditional therapy, honokiol, blocks key protein in inflammatory brain damage
5. Step forward in research into new treatments for brain edema
6. University of Alberta led research may have discovered how memories are encoded in our brains
7. Nanotherapy: Treating deadly brain tumors by delivering big radiation with tiny tools
8. Friendly to a fault, yet tense: Personality traits traced in brain
9. New discoveries about brain-hand connection sought to improve therapies, treatments, prosthetics
10. Autism risk gene linked to differences in brain structure
11. Amyloid beta in the brain of individuals with Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Brain tumor invasion along blood vessels may lead to new cancer treatments
(Date:9/21/2014)... working at the University of California, San Diego, have ... marks that control the activity of genes based on ... results from its application to human embryonic cells in ... September 21. , "All of our cells have the ... functions," said John Whitaker, lead author of the report. ...
(Date:9/19/2014)... Call it the Jimmy Durante of dinosaurs ... nasal profile. The new dinosaur, named Rhinorex ... University and Brigham Young University, lived in what ... during the Late Cretaceous period. , Rhinorex, which ... and a close relative of other Cretaceous hadrosaurs ...
(Date:9/19/2014)... species which over thousands of years has adapted to the ... that makes the cold dangerous for you. , This is ... and the cold provoking substance, called nonylphenol, comes from the ... suspected of being a endocrine disruptor, but when entering the ... ability to protect the cells in its body from cold ...
Breaking Biology News(10 mins):Program predicts placement of chemical tags that control gene activity 2New hadrosaur noses into spotlight 2Environmental pollutants make worms susceptible to cold 2Environmental pollutants make worms susceptible to cold 3
... Researchers have been unable to build an ideal photonic ... ultrafast optical computers. But now, University of Utah chemists ... with the ideal, diamond-like structure: They are found in ... Brazil. It appears that a simple creature like ...
... of the greatest zoological mysteries for over a century. ... puzzling crustaceans, despite the plethora of these larvae in ... what y- larvae grow up to be. A study ... reports the transformation of the larvae into a previously ...
... the Great Lakes have prompted the need to better ... collaborative project is aimed at improving information for beach ... close beaches to protect public health. This collaborative effort ... and other federal, state and local agencies. ...
Cached Biology News:The photonic beetle 2The photonic beetle 3The photonic beetle 4The photonic beetle 5Clue to mystery crustacean in parasite form 2To swim or not to swim? 2
(Date:9/19/2014)... CORAL SPRINGS, Florida , September 19, 2014 /PRNewswire/ ... biotech companies release latest developments, patents and results of ... (OTC: GNSZ), Eli Lilly and Company (NYSE: ... ), Celgene Corporation (NASDAQ: CELG ) and ... (OTCQB: GNSZ), a leader in developing prodrug therapeutics for ...
(Date:9/19/2014)... 2014 , The first grants ... Paediatric Endocrinology (ESPE) Meeting  Investment supports innovative ... in the field of growth  , EMD ... Germany , today announced the first recipients of ... awards were announced during a Satellite Symposium organized by ...
(Date:9/18/2014)... About POCT POCT, ... clinical laboratory. It helps in making fast clinical ... medication. POCT is gaining popularity due to the ... as diabetes, heart disease, and obesity. It is ... to minimize errors during the diagnosis of patients. ...
(Date:9/18/2014)... , September 18, 2014 ... ( http://www.researchandmarkets.com/research/czvg3s/biocompatible ) has announced the ... - Global Strategic Business Report" ... http://photos.prnewswire.com/prnh/20130307/600769) ,This report analyzes the worldwide ... Million by the following Product Segments: ...
Breaking Biology Technology:Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 2Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 3Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 4Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 5Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 6Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 7EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 2EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 3POCT Market in China 2014-2018 2Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3
... a positive third,quarter, the biotech industry continued its upward climb ... the state of the economy,and interest rate jitters as the ... Index, for example, rose an impressive 6.1% in,October -- in ... ahead of the,DJIA which was unchanged. "Entering the final ...
... COLUMBIA, Md., Nov. 1 Martek Biosciences,Corporation (Nasdaq: ... in the United,States District Court in Wilmington, Delaware, ... a permanent injunction in Martek,s favor,against the defendants ... Lonza, Ltd., Nutrinova Inc. and Nutrinova Nutrition Specialties ...
... provide free home caregiving to disabled veterans, ... its,2007 We Care For Veterans campaign to honor ... qualified disabled veterans. (Logo: http://www.newscom.com/cgi-bin/prnh/20070521/LAM004ALOGO ) ... are,donating 20 hours each of free in-home care ...
Cached Biology Technology:Biotech Continues Upward Climb in October 2Biotech Continues Upward Climb in October 3Biotech Continues Upward Climb in October 4Martek to Obtain Permanent Injunction Against Lonza in U.S. Patent Infringement Suit; Jury Verdict on Infringement of Two of Three Patents Upheld by Judge 2Martek to Obtain Permanent Injunction Against Lonza in U.S. Patent Infringement Suit; Jury Verdict on Infringement of Two of Three Patents Upheld by Judge 3Homewatch CareGivers Launches 2007 We Care For Veterans Campaign 2
... intensely fluorescent and highly photostable FluoSpheres ... in a variety of applications requiring ... signal. Unfortunately, protein- and other macromolecule-labeled ... cause them to bind to non-target ...
Goat polyclonal to Duffy / FY / DARC...
SMVT (N-14)...
... Source: Tritirachium album Description: ... endopeptidase used in a wide range of applications ... peptide bonds mainly following the carboxyl group of ... and is classified as a serine protease. ...
Biology Products: